SAFETY DATA SHEET

Creation Date 29-Jul-2009 Revision Date 24-Dec-2021 Revision Number 4

1. Identification
Product Name Titration solvent

Cat No. : ST93-4

Synonyms No information available

Recommended Use Laboratory chemicals.

Uses advised against Food, drug, pesticide or biocidal product use.

Details of the supplier of the safety data sheet

Company
Fisher Scientific Company
One Reagent Lane
Fair Lawn, NJ 07410
Tel: (201) 796-7100

Emergency Telephone Number CHEMTRECÒ, Inside the USA: 800-424-9300

CHEMTRECÒ, Outside the USA: 001-703-527-3887

2. Hazard(s) identification
Classification
This chemical is considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200)

Flammable liquids Category 2

Skin Corrosion/Irritation Category 2
Serious Eye Damage/Eye Irritation Category 2
Reproductive Toxicity Category 2
Specific target organ toxicity (single exposure) Category 3
Target Organs - Central nervous system (CNS).
Specific target organ toxicity - (repeated exposure) Category 2
Target Organs - Kidney, Heart, Liver, Neurological effects, Eyes, Ears.
Aspiration Toxicity Category 1

Label Elements

Signal Word
Danger

Hazard Statements
Highly flammable liquid and vapor

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May be fatal if swallowed and enters airways

Causes skin irritation
Causes serious eye irritation
May cause drowsiness or dizziness
Suspected of damaging the unborn child
May cause damage to organs through prolonged or repeated exposure

Precautionary Statements
Prevention
Obtain special instructions before use
Do not handle until all safety precautions have been read and understood
Use personal protective equipment as required
Wash face, hands and any exposed skin thoroughly after handling
Wear eye/face protection
Do not breathe dust/fume/gas/mist/vapors/spray
Use only outdoors or in a well-ventilated area
Keep away from heat/sparks/open flames/hot surfaces. - No smoking
Keep container tightly closed
Ground/bond container and receiving equipment
Use explosion-proof electrical/ventilating/lighting equipment
Use only non-sparking tools
Take precautionary measures against static discharge
Keep cool
Response
IF exposed or concerned: Get medical attention/advice
Inhalation
IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
Skin
If skin irritation occurs: Get medical advice/attention
IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower
Wash contaminated clothing before reuse
Eyes
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing
If eye irritation persists: Get medical advice/attention
Ingestion
IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician
Do NOT induce vomiting
Fire
In case of fire: Use CO2, dry chemical, or foam for extinction
Storage
Store locked up
Store in a well-ventilated place. Keep container tightly closed
Disposal
Dispose of contents/container to an approved waste disposal plant
Hazards not otherwise classified (HNOC)
None identified
WARNING. Reproductive Harm - https://www.p65warnings.ca.gov/.

3. Composition/Information on Ingredients

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Component CAS No Weight %

Toluene 108-88-3 50
Isopropyl alcohol 67-63-0 50

4. First-aid measures
General Advice If symptoms persist, call a physician.

Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Get
medical attention.

Skin Contact Wash off immediately with plenty of water for at least 15 minutes. If skin irritation persists,
call a physician.

Inhalation Remove to fresh air. If not breathing, give artificial respiration. Get medical attention if
symptoms occur. Risk of serious damage to the lungs (by aspiration).

Ingestion Clean mouth with water and drink afterwards plenty of water. Do NOT induce vomiting. Call
a physician or poison control center immediately. If vomiting occurs naturally, have victim
lean forward.

Most important symptoms and Difficulty in breathing. Inhalation of high vapor concentrations may cause symptoms like
effects headache, dizziness, tiredness, nausea and vomiting
Notes to Physician Treat symptomatically

5. Fire-fighting measures

Suitable Extinguishing Media Water spray, carbon dioxide (CO2), dry chemical, alcohol-resistant foam. Water may be
ineffective. Water mist may be used to cool closed containers. Water mist may be used to
cool closed containers.

Unsuitable Extinguishing Media Do not use a solid water stream as it may scatter and spread fire

Flash Point < 22.8 °C / < 73 °F

Method - No information available

Autoignition Temperature No information available

Explosion Limits
Upper No data available
Lower No data available
Sensitivity to Mechanical Impact No information available
Sensitivity to Static Discharge No information available

Specific Hazards Arising from the Chemical

Containers may explode when heated. Vapors may form explosive mixtures with air. Vapors may accumulate in confined areas
(basement, tanks, hopper/tank cars, etc.). May form explosive peroxides. Flammable. Vapors may travel to source of ignition and
flash back.

Hazardous Combustion Products

None known.
Protective Equipment and Precautions for Firefighters
As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full
protective gear.

NFPA
Health Flammability Instability Physical hazards
3 3 0 N/A

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6. Accidental release measures

Personal Precautions Use personal protective equipment as required. Ensure adequate ventilation. Remove all
sources of ignition. Take precautionary measures against static discharges.
Environmental Precautions Do not flush into surface water or sanitary sewer system.

Methods for Containment and Clean Soak up with inert absorbent material. Keep in suitable, closed containers for disposal.
Up Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment.

7. Handling and storage

Handling Wear personal protective equipment/face protection. Ensure adequate ventilation. Do not
get in eyes, on skin, or on clothing. Avoid ingestion and inhalation. Keep away from open
flames, hot surfaces and sources of ignition. Use only non-sparking tools. To avoid ignition
of vapors by static electricity discharge, all metal parts of the equipment must be grounded.
Take precautionary measures against static discharges.

Storage. Keep containers tightly closed in a dry, cool and well-ventilated place. Keep away from
heat, sparks and flame.

8. Exposure controls / personal protection

Exposure Guidelines

Component ACGIH TLV OSHA PEL NIOSH IDLH Mexico OEL (TWA)
Toluene TWA: 20 ppm (Vacated) TWA: 100 ppm IDLH: 500 ppm TWA: 20 ppm
(Vacated) TWA: 375 mg/m3 TWA: 100 ppm
Ceiling: 300 ppm TWA: 375 mg/m3
(Vacated) STEL: 150 ppm STEL: 150 ppm
(Vacated) STEL: 560 mg/m3 STEL: 560 mg/m3
TWA: 200 ppm
Isopropyl alcohol TWA: 200 ppm (Vacated) TWA: 400 ppm IDLH: 2000 ppm TWA: 200 ppm
STEL: 400 ppm (Vacated) TWA: 980 mg/m3 TWA: 400 ppm STEL: 400 ppm
(Vacated) STEL: 500 ppm TWA: 980 mg/m3
(Vacated) STEL: 1225 STEL: 500 ppm
mg/m3 STEL: 1225 mg/m3
TWA: 400 ppm
TWA: 980 mg/m3

Legend

ACGIH - American Conference of Governmental Industrial Hygienists

OSHA - Occupational Safety and Health Administration
NIOSH IDLH: NIOSH - National Institute for Occupational Safety and Health

Engineering Measures Ensure adequate ventilation, especially in confined areas. Use spark-proof tools and
explosion-proof equipment. Use explosion-proof electrical/ventilating/lighting equipment.
Ensure that eyewash stations and safety showers are close to the workstation location.

Personal Protective Equipment

Eye/face Protection Wear appropriate protective eyeglasses or chemical safety goggles as described by
OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard
EN166.

Skin and body protection Wear appropriate protective gloves and clothing to prevent skin exposure.

Respiratory Protection Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard
EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if
exposure limits are exceeded or if irritation or other symptoms are experienced.

Hygiene Measures Handle in accordance with good industrial hygiene and safety practice.

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9. Physical and chemical properties

Physical State Liquid
Appearance Clear
Odor pungent
Odor Threshold No information available
pH No information available
Melting Point/Range No data available
Boiling Point/Range No information available
Flash Point < 22.8 °C / < 73 °F
Evaporation Rate No information available
Flammability (solid,gas) Not applicable
Flammability or explosive limits
Upper No data available
Lower No data available
Vapor Pressure No information available
Vapor Density >1
Specific Gravity 0.82
Solubility Insoluble in water
Partition coefficient; n-octanol/water No data available
Autoignition Temperature No information available
Decomposition Temperature No information available
Viscosity No information available

10. Stability and reactivity

Reactive Hazard None known, based on information available

Stability Stable under normal conditions.

Conditions to Avoid Keep away from open flames, hot surfaces and sources of ignition.

Incompatible Materials Strong oxidizing agents

Hazardous Decomposition Products None under normal use conditions

Hazardous Polymerization Hazardous polymerization does not occur.

Hazardous Reactions None under normal processing.

11. Toxicological information

Acute Toxicity

Product Information
Oral LD50 Based on ATE data, the classification criteria are not met. ATE > 2000 mg/kg.
Dermal LD50 Based on ATE data, the classification criteria are not met. ATE > 2000 mg/kg.
Vapor LC50 Based on ATE data, the classification criteria are not met. ATE > 20 mg/l.
Component Information
Component LD50 Oral LD50 Dermal LC50 Inhalation
Toluene > 5000 mg/kg ( Rat ) LD50 = 12000 mg/kg ( Rabbit ) 26700 ppm ( Rat ) 1 h

Isopropyl alcohol 5045 mg/kg ( Rat ) 12800 mg/kg ( Rat ) 72.6 mg/L ( Rat ) 4 h
3600 mg/kg ( Mouse )
Toxicologically Synergistic No information available
Products
Delayed and immediate effects as well as chronic effects from short and long-term exposure

Irritation Irritating to eyes and skin

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Sensitization No information available

Carcinogenicity The table below indicates whether each agency has listed any ingredient as a carcinogen.

Component CAS No IARC NTP ACGIH OSHA Mexico

Toluene 108-88-3 Not listed Not listed Not listed Not listed Not listed
Isopropyl alcohol 67-63-0 Not listed Not listed Not listed Not listed Not listed
Mutagenic Effects No information available

Reproductive Effects Contains ingredients that are suspected reproductive hazards.

Developmental Effects Component substance is listed on California Proposition 65 as a developmental hazard.

Teratogenicity No information available.

STOT - single exposure Central nervous system (CNS)

STOT - repeated exposure Kidney Heart Liver Neurological effects Eyes Ears

Aspiration hazard Category 1

Symptoms / effects,both acute and Inhalation of high vapor concentrations may cause symptoms like headache, dizziness,
delayed tiredness, nausea and vomiting

Endocrine Disruptor Information No information available

Other Adverse Effects The toxicological properties have not been fully investigated.

12. Ecological information

Ecotoxicity
The product contains following substances which are hazardous for the environment. Contains a substance which is:. Toxic to
aquatic organisms.

Component Freshwater Algae Freshwater Fish Microtox Water Flea

Toluene EC50: = 12.5 mg/L, 72h 50-70 mg/L LC50 96 h EC50 = 19.7 mg/L 30 min EC50: = 11.5 mg/L, 48h
static (Pseudokirchneriella 5-7 mg/L LC50 96 h (Daphnia magna)
subcapitata) 15-19 mg/L LC50 96 h EC50: 5.46 - 9.83 mg/L, 48h
EC50: > 433 mg/L, 96h 28 mg/L LC50 96 h Static (Daphnia magna)
(Pseudokirchneriella 12 mg/L LC50 96 h
subcapitata)

Isopropyl alcohol EC50: > 1000 mg/L, 96h LC50: = 9640 mg/L, 96h = 35390 mg/L EC50 13299 mg/L EC50 = 48 h
(Desmodesmus flow-through (Pimephales Photobacterium 9714 mg/L EC50 = 24 h
subspicatus) promelas) phosphoreum 5 min
EC50: > 1000 mg/L, 72h LC50: > 1400000 µg/L, 96h
(Desmodesmus (Lepomis macrochirus)
subspicatus) LC50: = 11130 mg/L, 96h
static (Pimephales
promelas)
LC50: = 10000000 µg/L, 96h
(Daphnia)

Persistence and Degradability Insoluble in water

Bioaccumulation/ Accumulation No information available.

Mobility Is not likely mobile in the environment due its low water solubility.

Component log Pow

Toluene 2.7
Isopropyl alcohol 0.05

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13. Disposal considerations

Waste Disposal Methods Chemical waste generators must determine whether a discarded chemical is classified as a
hazardous waste. Chemical waste generators must also consult local, regional, and
national hazardous waste regulations to ensure complete and accurate classification.

Component RCRA - U Series Wastes RCRA - P Series Wastes

Toluene - 108-88-3 U220 -

14. Transport information

DOT
UN-No UN1993
Proper Shipping Name Flammable liquid, n.o.s.
Technical Name Isopropyl alcohol, Toluene
Hazard Class 3
Packing Group II
TDG
UN-No UN1993
Proper Shipping Name Flammable liquid, n.o.s.
Hazard Class 3
Packing Group II
IATA
UN-No UN1993
Proper Shipping Name Flammable liquid, n.o.s.
Hazard Class 3
Packing Group II
IMDG/IMO
UN-No UN1993
Proper Shipping Name Flammable liquid, n.o.s.
Hazard Class 3
Packing Group II
15. Regulatory information
United States of America Inventory

Component CAS No TSCA TSCA Inventory notification - TSCA - EPA Regulatory

Active-Inactive Flags
Toluene 108-88-3 X ACTIVE -
Isopropyl alcohol 67-63-0 X ACTIVE -

Legend:
TSCA US EPA (TSCA) - Toxic Substances Control Act, (40 CFR Part 710)
X - Listed
'-' - Not Listed

TSCA 12(b) - Notices of Export Not applicable

International Inventories
Canada (DSL/NDSL), Europe (EINECS/ELINCS/NLP), Philippines (PICCS), Japan (ENCS), Japan (ISHL), Australia (AICS), China (IECSC), Korea
(KECL).

Component CAS No DSL NDSL EINECS PICCS ENCS ISHL AICS IECSC KECL
Toluene 108-88-3 X - 203-625-9 X X X X X KE-33936
Isopropyl alcohol 67-63-0 X - 200-661-7 X X X X X KE-29363

KECL - NIER number or KE number (http://ncis.nier.go.kr/en/main.do)

U.S. Federal Regulations

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SARA 313
Component CAS No Weight % SARA 313 - Threshold
Values %
Toluene 108-88-3 50 1.0
Isopropyl alcohol 67-63-0 50 1.0

SARA 311/312 Hazard Categories See section 2 for more information

CWA (Clean Water Act)

Component CWA - Hazardous CWA - Reportable CWA - Toxic Pollutants CWA - Priority Pollutants
Substances Quantities
Toluene X 1000 lb X X

Clean Air Act

Component HAPS Data Class 1 Ozone Depletors Class 2 Ozone Depletors
Toluene X -

OSHA - Occupational Safety and Not applicable

Health Administration

CERCLA

Component Hazardous Substances RQs CERCLA EHS RQs

Toluene 1000 lb 1 lb -

California Proposition 65 This product contains the following Proposition 65 chemicals.

Component CAS No California Prop. 65 Prop 65 NSRL Category

Toluene 108-88-3 Developmental - Developmental
U.S. State Right-to-Know
Regulations

Component Massachusetts New Jersey Pennsylvania Illinois Rhode Island

Toluene X X X X X
Isopropyl alcohol X X X - X

U.S. Department of Transportation

Reportable Quantity (RQ): Y
DOT Marine Pollutant N
DOT Severe Marine Pollutant N

U.S. Department of Homeland This product does not contain any DHS chemicals.
Security

Other International Regulations

Mexico - Grade No information available

Authorisation/Restrictions according to EU REACH

Component REACH (1907/2006) - Annex XIV - REACH (1907/2006) - Annex XVII - REACH Regulation (EC
Substances Subject to Restrictions on Certain Dangerous 1907/2006) article 59 - Candidate
Authorization Substances List of Substances of Very High
Concern (SVHC)
Toluene - Use restricted. See item 48. -
(see link for restriction details)
Use restricted. See item 75.
(see link for restriction details)
Isopropyl alcohol - Use restricted. See item 75. -
(see link for restriction details)

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https://echa.europa.eu/substances-restricted-under-reach

Safety, health and environmental regulations/legislation specific for the substance or mixture

Component CAS No OECD HPV Persistent Organic Ozone Depletion Restriction of

Pollutant Potential Hazardous
Substances (RoHS)
Toluene 108-88-3 Listed Not applicable Not applicable Not applicable
Isopropyl alcohol 67-63-0 Listed Not applicable Not applicable Not applicable

Component CAS No Seveso III Directive Seveso III Directive Rotterdam Basel Convention
(2012/18/EC) - (2012/18/EC) - Convention (PIC) (Hazardous Waste)
Qualifying Quantities Qualifying Quantities
for Major Accident for Safety Report
Notification Requirements
Toluene 108-88-3 Not applicable Not applicable Not applicable Annex I - Y42
Isopropyl alcohol 67-63-0 Not applicable Not applicable Not applicable Annex I - Y42

16. Other information

Prepared By Regulatory Affairs
Thermo Fisher Scientific
Email: [email protected]

Creation Date 29-Jul-2009

Revision Date 24-Dec-2021
Print Date 24-Dec-2021
Revision Summary This document has been updated to comply with the US OSHA HazCom 2012 Standard
replacing the current legislation under 29 CFR 1910.1200 to align with the Globally
Harmonized System of Classification and Labeling of Chemicals (GHS).

Disclaimer
The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the
date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage,
transportation, disposal and release and is not to be considered a warranty or quality specification. The information
relates only to the specific material designated and may not be valid for such material used in combination with any other
materials or in any process, unless specified in the text

End of SDS

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