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    Hal 89

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    Khairina Herda
    This table provides parameters of pharmacokinetics and pharmacodynamics for various commonly used drugs. It lists the name of each drug along with its oral bioavailability, clearance rate, volume of distribution, half-life, effective concentration range, and toxic concentration range. The drugs included are furosemide, indomethacin, carbamazepine, quinidine, chloramphenicol, clordiazepoxide, chlorpropamide, meperidine, metoprolol, methotrexate, metronidazole, morphine, nifedipine, nortriptyline, procainamide, propranolol, ranitidine, and cefalexin.

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    Hal 89

    Uploaded by

    Khairina Herda
    3 views1 page
    This table provides parameters of pharmacokinetics and pharmacodynamics for various commonly used drugs. It lists the name of each drug along with its oral bioavailability, clearance rate, volume of distribution, half-life, effective concentration range, and toxic concentration range. The drugs included are furosemide, indomethacin, carbamazepine, quinidine, chloramphenicol, clordiazepoxide, chlorpropamide, meperidine, metoprolol, methotrexate, metronidazole, morphine, nifedipine, nortriptyline, procainamide, propranolol, ranitidine, and cefalexin.

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    This table provides parameters of pharmacokinetics and pharmacodynamics for various commonly used drugs. It lists the name of each drug along with its oral bioavailability, clearance rate, volume of distribution, half-life, effective concentration range, and toxic concentration range. The drugs included are furosemide, indomethacin, carbamazepine, quinidine, chloramphenicol, clordiazepoxide, chlorpropamide, meperidine, metoprolol, methotrexate, metronidazole, morphine, nifedipine, nortriptyline, procainamide, propranolol, ranitidine, and cefalexin.

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    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    3 views1 page

    Hal 89

    Uploaded by

    Khairina Herda
    This table provides parameters of pharmacokinetics and pharmacodynamics for various commonly used drugs. It lists the name of each drug along with its oral bioavailability, clearance rate, volume of distribution, half-life, effective concentration range, and toxic concentration range. The drugs included are furosemide, indomethacin, carbamazepine, quinidine, chloramphenicol, clordiazepoxide, chlorpropamide, meperidine, metoprolol, methotrexate, metronidazole, morphine, nifedipine, nortriptyline, procainamide, propranolol, ranitidine, and cefalexin.

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    of 1

    Tabel 6.

    4 Parameter farmakokinetik dan farmakodinamika obat-obat yang sering digunakan

    No Nama Obat Bioavaila- Klirens (ml/min) Volume Waktu paruh Konsen-trasi Konsentra-
    tas oral distribusi (L) (jam) efektif si toksik
    19. Furosemid 61 ± 7 140 ± 30 77 ± 1,4 1,5 ± 0,1 ˃25 µg/ml
    20. Indometasin 98 140 ± 30 18 ± 5 2,4 ± 0,4 0,3-3 µg/ml ˃5 µg/ml
    21. Karbamazepin >70 89 ± 37 98 ± 26 15 ± 5 6,5 ± 3 µg/ml ˃9 µg/ml
    22. Kuinidin 80 ± 15 330 ± 130 190 ± 80 6,2 ± 1,8 2-6 µg/ml
    23. Kloramfenikol 75 ± 90 170 ± 14 66 ± 4 2,7 ± 0,8
    24. Klordiazepoksid 100 38 ± 34 21 ± 2 10 ± 3 1 ug/ml
    25. Klorpropamid >90 21 ± 0,4 6,8 ± 0,8 33 ± 6
    26. Meperidin 52 ± 3 1200 ± 350 310 ± 60 3,2 ± 0,8 0,4-0,7 µg/m
    27. Metoprolol 38 ± 14 1050 ± 210 290 ± 50 3,2 ± 0,2 25 ng/ml
    28 Metotreksat 70 ± 27 150 ± 60 39 ± 13 7,2 ± 2,1 10 µm
    29. Metronidazol 99 ± 8 90 ± 20 52 ± 7 8,5 ± 2,9 3-6 µg/ml
    30. Morfin 24 ± 12 1600 ± 700 230 ± 60 1,9 ± 0,5 15 ng/ml
    31. Nifedipin 50 ± 13 490 ± 130 55 ± 15 1,8 ± 0,4 47 ng/ml
    32. Nortriptilin 51 ± 5 500 ± 130 1300 31 ± 13 50-140 ng/ml >500 ng/ml
    33. Prokainamid 83 ± 16 350 ± 480 130 ± 20 3,0 ± 0,6 3-14 µg/ml >14 µg/ml
    34. Propranolol 26 ± 10 480 ± 210 270 ± 40 3,9 ± 0,4 20 ng/ml
    35. Ranitidin 52 ± 11 730 ± 80 91 ± 28 2,1 ± 0,2 100 ng/ml
    36. Sefaleksin 90 ± 9 300 ± 80 18 ± 2 0,90 ± 0,18

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