Ciclo de Krebs, Fosforilacion Oxidativa, Cadena Respiratoria
Ciclo de Krebs, Fosforilacion Oxidativa, Cadena Respiratoria
Ciclo de Krebs, Fosforilacion Oxidativa, Cadena Respiratoria
GLYCOGENOLYSIS
glycogen glucose-6-phosphate glucose
GLYCOGEN SYNTHESIS ( 6 carbons)
GLUCONEOGENESIS
GLYCOLYSIS
pyruvate lactate
(3 carbons)
triacylglycerols
CO2
LIPASE
FATTY ACID SYNTHESIS
ketones acetyl CoA fatty acids
KETOGENESIS (2 carbons) FATTY ACID OXIDATION
oxaloacetate citrate
CO2
CO2
ESQUEMA MINIMO CICLO DE KREBS
acetyl CoA
(2 carbons)
oxaloacetate citrate
CO2
CO2
acetate (2C) condenses with oxaloacetate (4C) citrate (6C)
2 x decarboxylation reactions reformation of oxaloacetate
4 oxidation reactions and one substrate-level phosphorylation
The citric acid cycle – complete oxidation of acetyl CoA
2C
acetyl CoA
CoASH
NADH 4C 6C
oxaloacetate citrate
NAD+
cis-aconitate
4C 6C
malate isocitrate
NAD+
NADH CO2
H2O
4C 5C
ketoglutarate
fumarate
(oxo-glutarate)
FADH
NAD+
CoASH CoASH
FAD 4C 4C NADH
succinate succinyl CoA
GTP GDP, Pi
CO2
CH3
CICLO DE KREBS C O
SCoA
acetyl CoA
CoASH
COOH COOH
NADH
citrate synthase CH2 aconitase
C O
malate CH2 HO C COOH
NAD+
dehydrogenase CH2 cis- aconitate
COOH
oxaloacetate COOH
aconitase
citrate
COOH COOH
CHOH CH2
CH2 HC COOH
COOH HC OH
malate COOH
isocitrate
NAD+ oxalsuccinato
isocitrate dehydrogenase
H2O CO2
NADH
fumarase
COOH COOH
CH CH2
CH CH2
COOH C O
fumarate COOH
ketoglutarate
(oxo-glutarate)
COOH COOH
FADH
CH2 CH2 NAD
CoASH CoASH
CH2 CH2
FAD
COOH C O NADH
succinate dehydrogenase succinate SCoA
CO2
GTP GDP, Pi succinyl CoA ketoglutarate dehydrogenase
succinyl CoA synthetase
Condensation of acetyl CoA and oxaloacetate citrate
CH3
C O
SCoA
acetyl CoA
CoASH
COOH COOH
citrate synthase CH2
C O
CH2 HO C COOH
COOH CH2
oxaloacetate COOH
citrate
Isomerization isocitrate
COOH
CH2 aconitase Fe++
HO C COOH
CH2 cis- aconitate
COOH
aconitase
citrate
COOH
CH2
HC COOH
HC OH
COOH
isocitrate
Decarboxylation and oxidation ketoglutarate
COOH
CH2
HC COOH
HC OH
COOH
isocitrate
NAD+
isocitrate dehydrogenase oxalsuccinato
CO2
Mn++ NADH
COOH
Oxidation of NADH
in the electron transport chain CH2
3 x ATP CH2
C O
COOH
ketoglutarate
(oxo-glutarate)
Decarboxylation and oxidation succinyl CoA
COOH
CH2
CH2
Oxidation of NADH
in the electron transport chain C O
3 x ATP
COOH
ketoglutarate
(oxo-glutarate)
COOH
CH2 NAD
CoASH
CH2
C O NADH
SCoA
CO2
succinyl CoA
ketoglutarate dehydrogenase
B1 Lipoato
Substrate-level phosphorylation
COOH
COOH
CoASH CH2
CH2
CH2
CH2
C O
COOH
succinate SCoA
GDP, Pi
GTP
succinyl CoA
Succinato
succinyl tiocinasa
CoA synthetase
/ Succinyl CoA sintetasa
Mg++
Dehydrogenation carbon-carbon double bond
COOH
CH
Oxidation of FADH
CH in the electron transport chain
directly linked to reduction of ubiquinone
COOH 2 x ATP
fumarate
COOH
FADH
CH2
CH2
FAD
COOH
succinate dehydrogenase succinate
Addition of water across the carbon-carbon double bond
COOH
CHOH
CH2
COOH
malate
H2O
fumarase
COOH
CH
CH
COOH
fumarate
Oxidation to reform oxaloacetate
NADH COOH
C O
COOH
CHOH Oxidation of NADH
in the electron transport chain
CH2 3 x ATP
COOH
malate
GENERACION DE ENERGIA
CICLO DE KREBS C O
SCoA
acetyl CoA
CoASH
COOH COOH
NADH
citrate synthase CH2 aconitase
C O
*
malate CH2 HO C COOH
NAD+
dehydrogenase CH2 cis- aconitate
COOH
NAD oxaloacetate COOH
aconitase
citrate
COOH
Fe++ COOH
CHOH CH2
CH2 HC COOH
COOH HC OH
malate COOH
isocitrate
NAD+ oxalsuccinato
isocitrate dehydrogenase
*
H2O CO2
Mn++ NADH
fumarase
NAD
COOH COOH
CH CH2
CH CH2
COOH C O
fumarate COOH
ketoglutarate
(oxo-glutarate)
COOH COOH
FADH
CH2 CH2 NAD
CoASH CoASH
CH2 CH2
FAD
COOH C O NADH
succinate dehydrogenase succinate SCoA
CO2
GTP GDP, Pi succinyl CoA ketoglutarate dehydrogenase
FAD
succinyl CoA synthetase
B1 NAD Lipoato *
Mg++
CELLULAR RESPIRATION 3. TCA
https://www.youtube.com/watch?v=WXHpTHb1MQM&t=22s
AGENDA DEL MODULO II
GENERACION ENERGETICA
TIEMPO: 1 SEMANA
Se abordarán los aspectos relacionados a la
generación energética
1. Ciclo de Krebs
2. Cadena respiratoria
3. Fosforilación oxidativa
FECHA DE ENTREGA
FASE 1
Contrato de trabajo grupal 02 OCTUBRE
Mapa mental 30 OCTUBRE
INTEGRACION DE METABOLISMO
TRABAJO INTEGRACION ETAPA 2.
1. Preparar una infografía y un juego del tema asignado para compartir con el
curso y la organización con la que trabajaremos, pueden revisar
herramientas como Geneally, Adobe Spark, Picture Books u otro, para
plasmar la información de una manera agradable y divertida. 27
NOVIEMBRE
2. Preparar un ensayo de reflexión. 27 NOVIEMBRE
3. Presentar la infografía y el juego al curso 12, 13 DICIEMBRE
ATP
(adenosine triphosphate)
ADP (adenosine diphosphate)
+ phosphate
substrate I
oxidation NADH, H+ NADH deshidrogenasa
flavoprotein +FeS
CO2 NAD+
ADP + Pi
substrate II ATP
oxidation flavinH2
ubiquinone
CO2 flavin
Succinato ADP + Pi
deshidrogenasa
+ FeS ATP
III
cytochrome b
cytochrome c1 FeS
cytochrome c
½O2 IV ADP + Pi
cytochrome oxidase
H2O (cytochromes a and a3)
ATP
Cu
FOSFORILACION OXIDATIVA
SÍNTESIS DE ATP
NH2 O O
N N
N HN HN
N N H2N N N
H H O N
H
adenine guanine uracil
NH2
N
N
O O O
N N
O CH2 O P O P O P OH
OH OHOH
adenosine triphosphate (ATP)
OH OH
Presentation copyright © 2002 David A Bender and some images copyright © 2002 Taylor & Francis Ltd
An overview of the mitochondrial electron transport chain
substrate I
oxidation NADH, H+ NADH deshidrogenasa
flavoprotein +FeS
CO2 NAD+
ADP + Pi
substrate II ATP
oxidation flavinH2
ubiquinone
CO2 flavin
Succinato ADP + Pi
deshidrogenasa
+ FeS ATP
III
cytochrome b
cytochrome c1 FeS
cytochrome c
½O2 IV ADP + Pi
cytochrome oxidase
H2O (cytochromes a and a3)
ATP
Cu
IV
I III
II
INHIB IDO R ES DE L A CADENA R ESP IR ATO R IO Y
DE L A FO SFO R IL ACIÓ N OXIDAT IVA
Transportador
2,4,-dinitrofenol Agente desacoplante
transmembrana de H+
Transportador
Pentaclorofenol Agente desacoplante
transmembrana de H+
https://www.youtube.com/watch?v=vZz-KLK-X40
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