Statistical Analysis Which To Choose (Multivariable) 2021
Statistical Analysis Which To Choose (Multivariable) 2021
Statistical Analysis Which To Choose (Multivariable) 2021
Which to choose?
(Multivariable Analysis)
In d e p e n d e n t D ependent
P re d ic to r O u tc o m e
E x p la n a to ry R esponse
C o v a ria te s N o t th e p rim a r y
C o n fo u n d e rs in te re s t.
C o n tro ls M ust be
E ffe c t m o d ifie rs re c o g n iz e d
Syed Hatim Noor 3
Phenomena in statistics
• Confounding (C)
• Multicollinearity (M)
• Interaction (Effect modification) (I)
COMMONESS SEVERITY
C I
M M
I C
?
Risk Factor Disease
Confounder
Physical Systolic
Activity
? Blood
level pressure
Age
Interaction Factor
(=Effect Modifier)
Cigarette
smoking
Syed Hatim Noor 10
S m o k e rs
R is k o f
lu n g
cancer
N o n -sm o k e rs
Y e a rs o f e m p lo y m e n t in th e in d u s try
Purpose
1) To statistically adjust the effect on
variable Y by change in a particular
variable x when others are controlled
X1 Y
X2 X3 X4 …. Statistically adjusted for
E.g diet CHD smoking and
age adjusted for
Syed Hatim Noor 14
2) To discover the variable X which
has most influence on outcome
variable Y
diet
smoking CHD
age
Syed Hatim Noor 15
3) To predict the outcome Y
Clinical
Pathological cancer
Demographic Prognosis
Socio-economic