Pharmacotherapeutics For Advanced Practice Nurse Prescribers 4th Edition Woo Test Bank
Pharmacotherapeutics For Advanced Practice Nurse Prescribers 4th Edition Woo Test Bank
Pharmacotherapeutics For Advanced Practice Nurse Prescribers 4th Edition Woo Test Bank
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-prescribers-4th-edition-woo-test-bank/
Multiple Choice
Identify the choice that best completes the statement or answers the question.
____ 1. A patient’s nutritional intake and laboratory results reflect hypoalbuminemia. This is critical to
prescribing because:
1. Distribution of drugs to target tissue may be affected.
2. The solubility of the drug will not match the site of absorption.
3. There will be less free drug available to generate an effect.
4. Drugs bound to albumin are readily excreted by the kidneys.
____ 5. The NP chooses to give cephalexin every 8 hours based on knowledge of the drug’s:
1. Propensity to go to the target receptor
2. Biological half-life
3. Pharmacodynamics
4. Safety and side effects
____ 6. Azithromycin dosing requires that the first day’s dosage be twice those of the other 4 days of the
prescription. This is considered a loading dose. A loading dose:
1. Rapidly achieves drug levels in the therapeutic range
2. Requires four- to five-half-lives to attain
3. Is influenced by renal function
4. Is directly related to the drug circulating to the target tissues
____ 7. The point in time on the drug concentration curve that indicates the first sign of a therapeutic effect
is the:
1. Minimum adverse effect level
2. Peak of action
____ 8. Phenytoin requires that a trough level be drawn. Peak and trough levels are done:
1. When the drug has a wide therapeutic range
2. When the drug will be administered for a short time only
3. When there is a high correlation between the dose and saturation of receptor sites
4. To determine if a drug is in the therapeutic range
____ 9. A laboratory result indicates that the peak level for a drug is above the minimum toxic concentration.
This means that the:
1. Concentration will produce therapeutic effects
2. Concentration will produce an adverse response
3. Time between doses must be shortened
4. Duration of action of the drug is too long
____ 10. Drugs that are receptor agonists may demonstrate what property?
1. Irreversible binding to the drug receptor site
2. Upregulation with chronic use
3. Desensitization or downregulation with continuous use
4. Inverse relationship between drug concentration and drug action
____ 11. Drugs that are receptor antagonists, such as beta blockers, may cause:
1. Downregulation of the drug receptor
2. An exaggerated response if abruptly discontinued
3. Partial blockade of the effects of agonist drugs
4. An exaggerated response to competitive drug agonists
____ 14. When a medication is added to a regimen for a synergistic effect, the combined effect of the drugs is:
1. The sum of the effects of each drug individually
2. Greater than the sum of the effects of each drug individually
3. Less than the effect of each drug individually
4. Not predictable, as it varies with each individual
____ 16. Which of the following statements about the major distribution barriers (blood-brain or
fetal-placental) is true?
1. Water soluble and ionized drugs cross these barriers rapidly.
2. The blood-brain barrier slows the entry of many drugs into and from brain cells.
3. The fetal-placental barrier protects the fetus from drugs taken by the mother.
4. Lipid-soluble drugs do not pass these barriers and are safe for pregnant women.
____ 17. Drugs are metabolized mainly by the liver via phase I or phase II reactions. The purpose of both of
these types of reactions is to:
1. Inactivate prodrugs before they can be activated by target tissues
2. Change the drugs so they can cross plasma membranes
3. Change drug molecules to a form that an excretory organ can excrete
4. Make these drugs more ionized and polar to facilitate excretion
____ 18. Once they have been metabolized by the liver, the metabolites may be:
1. More active than the parent drug
2. Less active than the parent drug
3. Totally “deactivated” so they are excreted without any effect
4. All of the above
____ 19. All drugs continue to act in the body until they are changed or excreted. The ability of the body to
excrete drugs via the renal system would be increased by:
1. Reduced circulation and perfusion of the kidney
2. Chronic renal disease
3. Competition for a transport site by another drug
4. Unbinding a nonvolatile drug from plasma proteins
____ 21. Two different pain medications are given together for pain relief. The drug—drug interaction is:
1. Synergistic
2. Antagonistic
3. Potentiative
4. Additive
____ 22. Actions taken to reduce drug—drug interaction problems include all of the following EXCEPT:
1. Reducing the dosage of one of the drugs
2. Scheduling their administration at different times
3. Prescribing a third drug to counteract the adverse reaction of the combination
Language: English
Original publication: New York: The Cupples & Leon Company, 1907
Gutter Tragedies
Children of Earth
The Folly of the Wise
The Motor Pirate
The Cruise of the Conquistador
The Lady of the Blue Motor
"Five or seven? It won't matter much, will it?"
THE
MASTER CRIMINAL
BY
G. SIDNEY PATERNOSTER
NEW YORK
THE CUPPLES & LEON CO.
PUBLISHERS
COPYRIGHT, 1907, BY
G. SIDNEY PATERNOSTER
Later on that same morning all London was thrilled by the story
of a sensational burglary at the house of Mr. Hildebrand Flurscheim,
the noted connoisseur and dealer in objects of art.
Just at daybreak Mr. Flurscheim had been aroused by the
ringing of the burglar alarm, and, throwing on his dressing-gown, he
had rushed downstairs. There he had found the front door open,
and, running into the street, he commenced to blow frantically the
police whistle which he had in his hand—he always slept with a
police whistle attached to a ribbon round his neck and with a revolver
under his pillow.
He had not been compelled to waste much breath before the
summons was responded to, for a constable was almost instantly on
the spot.
Mr. Hildebrand Flurscheim dwelt in a quarter of London greatly
favoured by rank, fashion, and the children of Abraham. His house
was at the corner of a street turning into Park Lane, and at the shrill
sound of the whistle there emerged from turning after turning
helmeted men in blue who with one accord made their way at paces
varying with each man's temperament to the place where the excited
art dealer stood beckoning vigorously.
Mr. Flurscheim had speedily revealed his reason for giving the
alarm. The house was surrounded by constables, and two of the
force accompanied the owner back into his house, which they
proceeded to search systematically. At this time, Mr. Flurscheim had
not discovered his loss and was disposed to think that the electric
alarm had frustrated an attempt of someone to enter his abode. But
when he arrived, in the course of the search, at his drawing-room on
the first floor, he learned that the thief had been only too successful
in the object which had brought him thither. From the place on the
wall where the gem of his collection, the Greuze, which he had
sworn should never leave his possession until £20,000 should have
been paid into his banking account, had hung, only an empty frame
confronted him, while tossed carelessly aside on the table was an
ordinary table knife which had been used for the purpose of cutting
the canvas from the frame.
Upon the discovery of his loss, Mr. Flurscheim had for a while
been bereft of speech and movement. When volition returned to him,
he behaved as one demented. He wrung his hands, he tore his hair
and his clothes, and he called upon the God of Abraham and Isaac
and Jacob to visit his despoiler with condign punishment.
When a little later he discovered that some more of his choicest
treasures, the jewelled snuff-boxes of which he had the finest
collection in the world, had been carried away, he became absolutely
frantic with grief, so that even the policemen felt moved in their
hearts to pity him.
The frenzy did not endure long. A thing trifling in itself was
sufficient to restore the dealer to full possession of his senses. The
sergeant of police who had accompanied him into the room had
pulled out his note book in readiness to make notes of the
occurrence, when a clock on the mantel-shelf struck four. At the
sound, Flurscheim became still.
"Four o'clock," he murmured. "Four o'clock. There's no time to
lose. We must be doing." He turned to the policeman. "Sergeant," he
said dejectedly, "I shall trust you to forget the exhibition I have made
of myself—I——"
The sergeant answered briskly. "Very natural, I'm sure, sir.
Should have felt just like it myself, though I must admit I've put the
bracelets on many a man who hasn't said half as much as you have
done—of course, in the public streets, sir."
There was a sickly smile on Flurscheim's face as he answered:
"I hope none of them had such good reason for cursing as I have."
He did not pursue the topic. With an effort he forced his mind
from contemplation of the loss. "Hadn't we better leave things in this
room untouched, while we search the rest of the house? There may
be some one of the burglars, if there was more than one, still on the
premises."
The sergeant agreed. But the search was a fruitless one. Mr.
Flurscheim's butler and his four women servants were the only other
persons found on the premises, and after their unsuccessful search
the uniformed members of the force withdrew and the dealer sat
down to await the arrival of the detective with what patience he could
summon to his aid.
It was the bitterest moment in Flurscheim's career. Despite
Lynton Hora's sneer, it was not the monetary value of his loss which
troubled him, for though he dealt in pictures and other art objects, yet
he never parted with any of his treasures without a poignant feeling
of regret. When he sold them, however, he knew that they would
pass into appreciative hands, that they would be guarded carefully
and preserved jealously. To him they were what horses are to one
man or dogs to another. They were his companions, his friends, his
children—and to have the chief of them ruthlessly cut from its frame
and carried away, he knew not where, was as if his household had
been robbed of an only child.
He gazed forlornly at the empty frame. Since the Greuze had
come into his possession, never a night had passed without his
taking a last glance at it before going upstairs to bed, never a
morning dawned but he had feasted his eyes upon it before sitting
down to his breakfast. To live alone without the Greuze seemed to
him an unthinkable existence.
Yet the frame was empty. There took root in his heart a desire
for revenge upon the man who had robbed him.
That thought matured in the days which followed—the days
which came swiftly and passed swiftly, but without bringing him any
trace of his treasure, days in which the detectives continually buoyed
him up with hopes that his picture was on the ace of being restored
to him.
They had indeed thought that the task would not have proved a
difficult one. Their inspection of the room from which the picture had
been stolen had led to the discovery of a number of clues to work
upon. They decided that an entry must have been effected through a
window which opened upon the portico over the front door. At that
window were a number of scarlet berried shrubs, and some of the
berries were found crushed on the carpet inside. On the balcony
they discovered a palette knife, with smears of cobalt and chrome
upon it, which obviously had been used to force back the catch of
the window. For days afterwards, detectives might have been
observed knocking at the doors of London studios and offering
themselves as models to aspiring Academicians, in the hope of
ascertaining the whereabouts of the missing picture. But they found
no trace of the Greuze.
On the knife-handle too, were unmistakable finger-prints, and on
the empty frame were others. All were photographed, and hope was
strong that the identity of the thief would be disclosed thereby,
through comparison with the records of convicts at Scotland Yard.
But when the first comparison seemed to point to the fact that every
print was that of a different person, and closer investigation proved
that the dirty smudges were not finger-prints at all, the problem
became indubitably more complex. As for the knife which had been
used to cut the canvas from the frame, that was an ordinary table-
knife, of which counterparts might have been discovered in every
mean house in the metropolis, and it supplied no basis for any theory
as to the owner. The one fact which chiefly puzzled Scotland Yard,
however, was the fact that no suspicious characters had been
observed anywhere in the neighbourhood, while the position of the
house was such that it was particularly open to observation.
Standing at the corner of two streets, in a neighbourhood where
all the houses would be described in a house agent's catalogue as
"highly desirable family town residences," it was under observation
from at least three quarters. The streets at three or four o'clock were
at that time practically empty of all pedestrians save the police. Yet
not a member of the police on duty in the vicinity had seen a
suspicious looking character.
This was the more astonishing, because two extra constables
were on duty that night in the near neighbourhood. They had been
detailed for duty at the town mansion of one of the most popular of
society hostesses, Lady Greyston, who was giving the first of her
dances for the season. Lady Greyston's house was only six removed
from Mr. Flurscheim's, and until three o'clock one of the constables
had been stationed at the corner of the street, practically at Mr.
Flurscheim's front door, in order to direct the carriages arriving to
pick up departing guests. The stream of carriages had thinned
shortly after three, and then the constable had joined a colleague at
the door, but at no time during the night had anything out of the way
attracted his attention. The police were quite at a loss for an object of
suspicion.
But while Scotland Yard was hopelessly at a loss for a clue, the
newspapers had been busy printing stories of the crime, which did
great credit to the fertility of the imagination of the reporters who
were detailed to work up the case. Those who read these stories
might have had warrant almost for believing that each writer must
have been the principal, so intimately and minutely was the crime
reconstructed.
But throughout the public excitement and conjecture which the
burglary created, Lynton Hora and Guy remained entirely
undisturbed, or, at the most, merely stirred to mild amusement as
each new theory was evolved—each was so very wide of the mark.
Yet audacious as many of these theories were, none of them
paralleled the audacity of the real attempt.
How the burglary had been carried out was explained by Guy
when, refreshed by six hours' sleep and a cold bath, he joined Myra
and Hora at the breakfast table.
"I followed your plans almost exactly," he said to the elder man,
"and I found the interior of the house precisely as you described it."