Pentravan®

Emulsion base for transdermal drug delivery

Advantages of
transdermal drug
delivery
• Avoids gastrointestinal (GI) drug
absorption difficulties caused by
GI pH, enzymatic activity and drug
interactions with food, drink, and
other orally administered drugs
• A substitute for other routes
of administration (e.g. oral
administration, intravenous
injection) when that route is
unsuitable, due to vomiting,
swallowing problems, resistant
children and diarrhea
• Avoids the first-pass effect, possibly
avoiding the deactivation by
digestive and liver enzymes
• Patient acceptability. Transdermal
delivery is noninvasive, avoiding the
inconvenience of parenteral therapy
• Ability to dissolve a wide range of
medications with different chemical
properties, achieving therapy with
one transdermal cream possible
• Provides extended therapy with
a single application, improving
compliance
Pentravan® • Drug therapy may be terminated
rapidly by removal of the application
Pentravan® is an oil-in-water transdermal liposomes of Pentravan® penetrate the from the skin surface¹-²
cream with a liposomal matrix that uses stratum corneum through the intercellular
penetration enhancing ingredients that channels. After the penetration of stratum fagron.gr
enable it to establish a greater rate and corneum, drug molecules may pass
extent of absorption of the drug than through the deeper epidermal tissues and
other transdermal bases. Therefore, more into the dermis. When the drug reaches
of the drug will become available in a the vascularised dermal layer, it becomes
shorter time to establish the effect of the available for absorption into the systemic
therapy. Besides that, Pentravan® is a true circulation.
vanishing cream, leaving no sticky residue
and providing a cosmetically elegant skin Pentravan® allows for individualized
feel. Therefore, there is no need to cover the therapy and more accurate dosing. For
area of application to prevent transferring more information about Pentravan® please
of the cream and to ensure effectiveness of contact [email protected].
therapy. It is preserved and fragrance-free.

After application on the skin, the drug

molecules that are dispersed within the
Pentravan®

Transdermal absorption

Skin barrier function

The epidermis acts as a protective barrier only. Thus, the skin barrier protects the
for the human body remarkably well. The body from external and potentially harmful
skin barrier permits the transit through the agents.
skin molecules with particular specifications

How it works

Transdermal absorption of a drug leads to of the SC and forms a major route of drug
from direct penetration of the drug through penetration. Once through the SC, the
the stratum corneum (SC). It is the outer of drug molecules pass the deeper epidermal
the epidermis; a 10 to 15 μm thick layer of tissues, into the dermis and finally will
flat, partially dehydrated tissue. The lipid reach the vascularised dermal layer. Then,
content is concentrated in the extracellular it becomes available for absorption in the
phase general circulation.

Compounding formulations for pain

management treatment using Pentravan®
Hemorrhoids Postherpetic neuralgia Postherpetic neuralgia
Rx/ Rx/ Rx/
Fagron Derma Pack NLP Fagron Derma Pack KALP Fagron Derma Pack GKALP
Nifedipine 0.3% Ketoprofen 10% Gabapentin 10%
Lidocaine 1 % Aciclovir 5% Ketoprofen 5%
Pentravan® Lidocaine hydrochloride 5% Amitriptyline hydrochloride 2%
Pentravan® Lidocaine hydrochloride 5%
Pentravan®

Pentravan® vanishes into the skin

while enhancing the penetration
References: of the compounded preparation
1 Vadaurri V. Topical treatment of neuropathic pain. International Journal of Pharmaceutical Compounding.
2008; 12(3): p. 182-190. Pentravan® is an oil-in-water transdermal
2 Sharma N, Agarwal G, Rana AC et al. A review: transdermal drug delivery system: a tool for novel drug cream that uses liposomal technology to
delivery system. International journal of drug development & research. 2011; 3(3): p. 70-84.
ensure effective and proven transdermal
drug delivery.

Disclaimer: While a great deal of effort has been spent to ensure the accuracy of the formulations contained herein, no claims are made as to
the uses, safety, efficacy or bioavailability of these recommendations. The content of this brochure cannot be construed as (medical) advice,
recommendation or opinion. Medical professionals, doctors and compounding pharmacists using this information are advised to do so solely if
appropriate in their own professional opinion and judgement. Fagron does not accept and cannot be held responsible or liable in any case for
the formulations or information contained herein.

fagron.gr Fagron Hellas - 12 km N.R. Trikala-Larissa - P.C. 42100 Trikala

Tel. +30 (0) 24310 83633-5 - Fax +30 (0) 24310 83615 - [email protected]