Assessment and Management of The Unconscious Patient

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MOHW August 2020

Assessment and Management of the


unconscious patient
Adapted from NICE Guidelines 2020

1. A good proper history and clinical examination is mandatory. The


unconscious patient is traditionally defined on having a GCS of 8 or less.

2. Priorities in management will follow CAB principles:


a. Circulation:
i. Pulse and Blood pressure
ii. Establish IV access

b. Airway
i. Ensure an adequate airway

c. Breathing

d. Disability
i. Glasgow Coma Score

ii. Full neurological examination


1. Pupils
a. Unilateral dilatation: Intracerebral bleed,
cerebral infarct or tumour
b. Bilateral pinpoint: Pontine bleed or infarct
: Opiate or
organophosphorus
poisoning

c. Bilateral dilated: Benzodiazepine or Tricyclic


Antidepressants
2. Neck rigidity
a. Meningitis
b. Subarachnoid haemorrhage

3. Check for any neurological deficit

3. Exposure
a. Check for rash
i. Meningitis (Purpura fulminans)
ii. Septicaemia

b. Puncture mark: Drug overdosage

c. Tongue bite: Epilepsy

4. Check Glucose level


a. Hypoglycaemia: Blood glucose less than 4.0 mmol/L

5. After a detailed history and clinical examination, appropriate


investigation and treatment is initiated like:

a. Hypoglycaemia: should be treated immediately with intravenous


50% Dextrose 50ml

b. Overdose of Opiate: Intravenous Naloxone 0.4-2.0 mg, to repeat


2-3 minutes PRN, not exceeding 10mg

c. Overdose of Benzodiazepine: Intravenous Flumazenil 0.2 mg 15-


30s, if no response to administer 0.3mg over 30s

d. Meningococcal meningitis: Intravenous antibiotic should be given


immediately (see Protocol for meningitis)
e. Acute cerebrovascular accident

i. Ischemic

Initial management of suspected and confirmed TIA

Offer aspirin (300 mg daily), unless contraindicated, to


people who have had a suspected TIA, to be started
immediately.

Do not offer CT brain scanning to people with a suspected TIA


unless there is clinical suspicion of an alternative diagnosis
that CT could detect.

Brain imaging for the early assessment of people with suspected acute stroke

Perform brain imaging as soon as possible with a non-enhanced CT for


people with suspected acute stroke if any of the following apply:

• on anticoagulant treatment

• a known bleeding tendency

• a depressed level of consciousness (Glasgow Coma Score below 13)

• unexplained progressive or fluctuating symptoms

• papilloedema, neck stiffness or fever

• severe headache at onset of stroke symptoms

• indications for thrombolysis or thrombectomy- If available

Perform scanning as soon as possible and within 24 hours of symptom


onset in everyone with suspected acute stroke without indications for
immediate brain imaging
Aspirin and anticoagulant treatment

People with acute ischaemic stroke

Offer the following as soon as possible, but certainly within 24 hours, to


everyone presenting with acute stroke who has had a diagnosis of
intracerebral haemorrhage excluded by brain imaging:

• aspirin 300 mg orally if they do not have dysphagia

● Do not use anticoagulation treatment routinely for the treatment


of acute stroke.

People with acute venous stroke


Offer people diagnosed with cerebral venous sinus thrombosis (including
those with secondary cerebral haemorrhage) full-dose anticoagulation
treatment (initially full-dose heparin and then warfarin [international
normalised ratio 2 to 3]) unless there are comorbidities that preclude its
use.
Anticoagulation treatment for other comorbidities
● Ensure that people with disabling ischaemic stroke who are in
atrial fibrillation are treated with aspirin 300 mg for the first 2
weeks before anticoagulation treatment is considered. [2008]
● For people with prosthetic valves who have disabling cerebral
infarction and who are at significant risk of haemorrhagic
transformation, stop anticoagulation treatment for 1 week and
substitute aspirin 300 mg.
● Ensure that people with ischaemic stroke and symptomatic
proximal deep vein thrombosis or pulmonary embolism receive
anticoagulation treatment in preference to treatment with aspirin
unless there are other contraindications to anticoagulation.
● Treat people who have haemorrhagic stroke and symptomatic
deep vein thrombosis or pulmonary embolism to prevent the
development of further pulmonary emboli using either
anticoagulation.
Statin treatment

● Immediate initiation of statin treatment is not recommended in


people with acute stroke
● Continue statin treatment in people with acute stroke who are
already receiving statins.

Provide optimal insulin therapy, which can be achieved by the use of


intravenous insulin and glucose, to all adults with type 1 diabetes with
threatened or actual stroke.
Blood pressure control for people with acute ischaemic stroke
Refer to hypertension guidelines.
Anti-hypertensive treatment in people with acute ischaemic stroke is
recommended only if there is a hypertensive emergency with one or
more of the following serious concomitant medical issues:
• hypertensive encephalopathy
• hypertensive nephropathy
• hypertensive cardiac failure/myocardial infarction
• aortic dissection
• pre-eclampsia/eclampsia.

Hemorrhagic
Aim for adequate Blood pressure control for people with acute
intracerebral haemorrhage
Refer to the neurosurgical team for further management.

For people with acute stroke consider the following


Optimal positioning
Early mobilisation
Avoiding aspiration pneumonia

6. If no neurological deficit present, consider alcohol/sleeping


pill/Diazepam overdosage
a. Monitor vitals and Plan for investigation accordingly: FBC, Urea
and Electrolytes, creatinine, Blood glucose, Urine/Blood/Gastric
Aspirate for Toxicology and CT scan/MRI brain as required.

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