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    Advancing Genome Editing Thru CRISPR-COPIES: An Article Review For The Newly-Developed Tool To Revolutionize CRISPR-Cas9 Gene Editing

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    Alexander Joel Osia
    1) The document reviews a new gene editing tool called CRISPR-COPIES developed by the University of Illinois that can quickly identify optimal sites in a genome for integrating genetic changes. 2) Using CRISPR-COPIES, researchers were able to modify cells from three organisms to produce more of a useful molecule. 3) This new tool advances the field of gene editing and could have applications for improving human health, agriculture, and industry.

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    Advancing Genome Editing Thru CRISPR-COPIES: An Article Review For The Newly-Developed Tool To Revolutionize CRISPR-Cas9 Gene Editing

    Uploaded by

    Alexander Joel Osia
    6 views2 pages
    1) The document reviews a new gene editing tool called CRISPR-COPIES developed by the University of Illinois that can quickly identify optimal sites in a genome for integrating genetic changes. 2) Using CRISPR-COPIES, researchers were able to modify cells from three organisms to produce more of a useful molecule. 3) This new tool advances the field of gene editing and could have applications for improving human health, agriculture, and industry.

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    Advancing Genome Editing Thru CRISPR-COPIES: An Article Review for the newly-developed tool to revolutionize CRISPR-Cas9 gene editing

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    1) The document reviews a new gene editing tool called CRISPR-COPIES developed by the University of Illinois that can quickly identify optimal sites in a genome for integrating genetic changes. 2) Using CRISPR-COPIES, researchers were able to modify cells from three organisms to produce more of a useful molecule. 3) This new tool advances the field of gene editing and could have applications for improving human health, agriculture, and industry.

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    © All Rights Reserved
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    6 views2 pages

    Advancing Genome Editing Thru CRISPR-COPIES: An Article Review For The Newly-Developed Tool To Revolutionize CRISPR-Cas9 Gene Editing

    Uploaded by

    Alexander Joel Osia
    1) The document reviews a new gene editing tool called CRISPR-COPIES developed by the University of Illinois that can quickly identify optimal sites in a genome for integrating genetic changes. 2) Using CRISPR-COPIES, researchers were able to modify cells from three organisms to produce more of a useful molecule. 3) This new tool advances the field of gene editing and could have applications for improving human health, agriculture, and industry.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 2

    Name: Alexander Joel N.

    Osia Subject: General Chemistry 1


    Grade and Section: STEM 11-Newton Teacher: Sir Mark Gil Ramos

    Advancing Genome Editing Thru CRISPR-COPIES: An Article Review for the newly-
    developed tool to revolutionize CRISPR-Cas9 gene editing

    CRISPR-Cas9, popularly known as CRISPR, is a shortened term for “clustered


    regularly interspaced short palindromic repeats” and Cas9 pertaining to an enzyme that acts
    like a pair of molecular scissors, capable of cutting strands of DNA, is a powerful novel
    technological advancement that enables scientists to edit the DNA and genomic sequences of
    living organisms thru the removal, addition, or alteration of sections of the DNA sequence
    (Smith, 2024; Lanese & Vidyasagar, 2023). According to the Broad Institute, CRISPR
    genome editing allows scientists to create cell and animal models that could help various
    medical applications such as: acceleration of research on diseases such as HIV, cancer and
    mental illnesses, gene therapy, rapid disease diagnosis, advancing agricultural and
    biotechnological growth, among others
    It's been Introduced that the CRISPR/Cas system would be a cheaper, faster and more
    effective way of gene editing. That’s why over the past decade, this technology has gone
    tremendous advancements that help the technology produce a more precise editing tool. One
    of it’s major advancement is the development of the CRISPR-COPIES by the University of
    Illinois at Urbana-Champaign Institute for Sustainability, Energy, and Environment.
    According to Huimin Zhao, Center for Advanced Bioenergy and Bioproduct
    Innovation (CABBI) Conversion Theme Leader and Steven L. Miller Chair of Chemical and
    Biomolecular Engineering (ChBE) at the University of Illinois. “CRISPR-COPIES is a tool
    that can quickly identify appropriate chromosomal integration sites for genetic engineering in
    any organism.” CRISPR-COPIES (with COPIES bieng an acronym of “COmputational
    Pipeline for the Identification of CRISPR/Cas-facilitated intEgration Sites) is said to be the
    solution for the long unsolved problem of locating optimal integration sites in the genome for
    gene edits.
    To demonstrate the versatility and scalability of this new technology, in their
    published paper in the Nucleic Acid Research the proponents of this research characterized
    integration sites in three diverse species: Cupriavidus necator, Saccharomyces cerevisiae, and
    HEK 293T cells. Through the utilization of the integration sites they discovered, they were
    able to genetically modify cells to produce more 5-aminolevulinic acid, a useful molecule
    having uses in the food and agricultural industries.
    This new advancement would be important in the studies of Chemistry as it could
    illustrate how chemistry could be applied to better understand and manipulate the carrier of
    the important genetic information of life—the DNA. As CRISPR gene editing implies to the
    chemical interaction between DNA molecules and enzymes (Cas9) that could alter DNA
    segments. Thru the help of this marvelous advancement, we could now further understand
    mechanics, structure, and chemical reactions made by DNA, which could aid is
    understanding life.
    In an individual aspect, as someone who is fascinated and interested in these field of
    sciences—genetics, biotechnology, and medicine, this research is a great innovation. The
    CRISPR-COPIES is being utilized to create new grasses and yeasts for biochemical
    production, or to treat diseases caused by genetic mutations. This will benefit me as an
    individual, and us, in general, in various ways: the creation of new grass and yeast could help
    increase food supply therefore everyone could have a food on their plate, and treating
    diseases caused by genetic mutations such as cancer will be a great feat in human history that
    could save if not thousands, millions of lives—including mine.
    In the aspect of national development, the potential of CRISPR-COPIES gene editing
    tool to enhance and revolutionize sustainability, efficiency, and diversity of the country’s
    biological resources could be highlighted as a contribution to the country’s progress.
    Moreover, as the proponents of this development proposes the use of this technology in
    production of bioproducts such as biofuels and bioplastics, it could help our country reduce
    our dependence from fossil fuels and avoid serious environmental impacts of anthropogenic
    activities. Furthermore, as mentioned earlier, once used in the medical field, CRISPR-
    COPIES could save millions of lives, improving the health and well-being of our
    countrymen.
    In the article, Wendling (2024) reached into a vital conjuncture that “Researchers
    around the world in both academia and industry can benefit from its utility in strain
    engineering for biochemical production and transgenic crop development.” Hence, proving
    the importance of the development of CRISPR-COPIES tool not just in the national level, but
    also at the international standpoint.

    REFERENCES
    Main Article Reviewed
    Wendling, A. (2024). CRISPR-copies: New tool accelerates and optimizes genome editing.
    ScienceDaily. https://www.sciencedaily.com/releases/2024/02/240213130512.htm

    Auxiliary Articles
    Broad Institute (n.d.). Questions and Answers about CRISPR.
    https://www.broadinstitute.org/what-broad/areas-focus/project-spotlight/questions-
    and-answers-about-crispr
    Lanese, N. & Vidyasagar, A. (2023). What is CRISPR, the powerful genome-editing tool?.
    LiveScience. https://www.livescience.com/58790-crispr-explained.html
    Smith, M. (2024). CRISPR. National Human Genome Research Institute.
    https://www.genome.gov/genetics-glossary/CRISPR

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