lOMoARcPSD|39639721

Metabolic Map

Intro Biochemistry (University of Michigan)

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 lOMoARcPSD|39639721

Biochemistry Metabolic Pathway Map Arrow color Key

Redox reaction (NADH/ FADH2)
Energy (ATP/ GTP)
Indicate the location of the following on the chart CO2
1. Fatty Acid synthesis H2O
2. Oxidative Pentose phosphate pathway H+

Ei
3. Urea cycle
4. GLUT1 Transporter and Na/K ATPase
5. Polarity of plasma membrane and polarity of mitochondrial membrane (use +/- sign) ⑤ Extracellular space

-0 ATP lawn
Cytoplasm
,
carnitine OUTER MITOCHONDRIAL
MEMBRANE
g. con .

CoA SH

FA synthesis
Carnitine
-

arnitine

Acyltransferase-I ,

⑤
Glycolysis and Gluconeogenesis
mitochondria ,
inner

Carnitine
Membrane
1

Acyltransferase-II

÷÷÷÷"
Enzymes
Glucose A- art
Citrate
1
R d ? carnitine Cycle
transporter transporter -

citrate
'

carnitine
ATP Beta Oxidation
1 hexokinate
14 1 * ✓
p
?g
ate

④ glucose phosphatase nApH+H+NaAD+ malate MR c

)
6-
-

pig .com

" WA SH ""
. -

DH
acyl-CoA
H2O
⑧ O GHz " "
" ETF
ftp. ubiquinone
-
-

FADH , oxidoreductase
É Dehydration
③ hexose isomerase H
F-0¥
1 -

ooo -

city - -
coo
-
malate
alutoglutaate # enoyl con R
-
cha -

É=É -
-
" A

,/
.

trans
-

phospho
-
.

phosphate
2 transporter 11-20
Glucose 6.
,-µ;µ
ma.me
Hit pe.p.na.yg.am
,+µ+Asp"?%%uia"jiaj÷÷oo
µ " "
"
" """ " "
'
.

""or "" "

"
NADPT
-0T¥
I

[
'

H OH c Coo
NADHDH

§Éij ÷%
-

pit
-

ÑAnapi++µ Hydration
.

it
nappy
i-p-itydnxyacyi-con-r-citz-e-citi-c-s.int
'

,,+µ+"o
⑧ -0-01+2
"

"

if
"
°O° ' "
-

glutamate
-

ATP
-

OH
-

1- OYA

"""";;!¥÷
-

oxaloacetate
g) ppy .
,
,
"" na
13 3 ADP
H%µ Fructose -6
phosphate P hydroxy acyl DH
-

con
-
- -

ze
.

fpgpage ,
/
\
.

Ht
⑤
rim it * Dehydrogenation
NADH +

j-É
S ↳ A
f
-

cha cha
-

CoA R
§
-

B- ketoacyl
-

H2O
-
- -

°" Aspartate a
°
""" "
Punter 3
CoA SH
pyruvate
-

glutamate
⑧ -
o
-

GHz
4) aldolase ⑥ aspartate
acyl-CoA acetyltransferase
f- OYA -0
-

, transporter
4 ( thiolate) 7
ial

bisphosphate ¥ "" s ↳A
cltz
Fructose 1,6
con-lmyristoyl-con-R-cltz-fg-S.com §
- -

+ -
Mitochondr

H
Thjolygig
-

☐ HAP GAP µ Acyl

O-CHz-cy.ci
-
porins

⑧ o cha f cHz0H ⑧
" "° Pyruvate dehydrogenase
- - -

"
""
"
-
rter

" " "" " °

-
transpo te

'
,
jµ
H
°" "
→
MM
complex
Pyruva

°
5
phosphate isomerase 2x

*ny
'

2NADt+2Pi
?
,
I 3-
2x

Bispnosphtglylhote y,
prosthetic
groups
: TPP , hpodte ,
"
+3 -
c

con .
Acetyl-CoA
C14
6) GAPPA ⑧ CH >

¥;
o c.

!
⑥ fa☐
- -
-
"

C12
-

y,
,
6 o "" " "
-

" "" " + "

+
" "" " ^"
C10
"
WA
Acetyl
"
-

Phosphate C8
"

Acetyl-CoA
"

Ht Symport translocase

①
NA"
]
" "

ZY At E3 Acetyl-CoA Acetyl-CoA C6
o
"
g. con .

NADH
ZADP
"
Hzpby C4
3- Phosphoglycerate i-oeatg.ci Acetyl-CoA
" "

"
CH C
Happy
-
-
→
⑧ o ut , J
-
- -

7 ditz
, ,

1 ,
7) kinase
phosphoglycerate ZATP OH
Adenine nucleotide
we

oxaloacetate Acetyl-CoA
sub -
level phos ADP translocase
Hao
-

COO
SH
A
=L ↳ escort citrate
-

o ATP
if
☐
" 24 "" ""
'

gita
-

* "" " Mh " " "" " " "

" P" "M°M°° ""
"
"
P 'M "
" "

" " "

""
"

°
"
"

f
'

8 NADH +1++000
☐µ citrate synthase can -
ooo
-

⑤ -

+ + NAH
L -
malate DH aconitase
isocitrate
-

malate cHz Coo

ATP

L
-

O
ATP " -
Hd -
Coo
-

"
Ñ
"°
a) enolate
"
Ht Ht d- it
> synthase c- Ho -

12 Hz :C,
C Howl too
ADP

c. "
-

"" "
"

+002 9 ° "

Yi;"°
" "
2H2O P M Coz
ump O
c.
PEP "
NADCP>+
Krebs Cycle
H2O

carboxy kinase ⑧ fumarate isocitrate DH

u

shuttle NADLP)HtH+
Electron Transport Chain

IV Ht
,
malate zyy OH
-

..÷.÷ .

oxaloacetate
.
" ZX the
.
fumarate
a.m.
+

ZADP
- -

ca
ze coo
.
-

kinase
) pyruvate Hz f Ceo
11ft ditz
-

µ
pyruvate
"
'

c. ' 00
-

10 , -

Cyt c
'
c- coo
-
+

ZATP
④ pyruvate
°
INAPH
I -
coz
-00C µ
Pyruvate (2) NADT
FADA,
É
carboxylate -
DH
4TH III succinate DH a- ketoglutarate
M
ZAPP 11 ZATP 1- CO2 Frett NADH
group
CoQ (t2Ht FAD
"

succinyl-COA
succinate
synthetase
II 211 succinyl-CoA
e-
FADHtnzmo.me succinate
☐µ,
-

CHZ -
COO

tH+ { Hz
-

Me produced 400
I
-

" S WA
41ft
I c-
can
-

ktebs GDP / ADP+Pi 8

GTP / Atp
Mitochondrion
i

µ
µ - oxi CHZ
]
ps
-

"
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