REVIEW ARTICLE Sept-Oct 2021

Systematic review of Priyangu (Callicarpa macrophylla)

Monika Paprikar1, Manoj Paprikar2
1
Associate Professor, Dept of Dravyaguna, Ashvin Rural Ayurved College and Hospital, Manchi Hills, Sangamner,
Maharashtra, India.
2
Classified Specialist (Obs & Gyn), Military Hospital, Devlali, Maharashtra, India.

ABSTRACT
In this modern era of scientific research, traditionally used medicines are being researched and used.
Priyangu or Callicarpa macrophylla is a medicinal plant which has references in Charak Samhita and
Nighantus. It is widely used in Ayurveda. We searched for all the references in Charak Samhita and
other Nighantus. We searched PubMed, Google Scholar, Researchgate, Sciencegate and other internet
resources for all the published papers. Its phytochemistry, active ingredients, mechanism of action
and clincal uses are being studied. It is Pittashamak and effective in Raktapradoshaja Vikaras as per
Ayurveda. Its anti-bacterial, analgesic, anti-inflammatory, anti-arthritic, antifungal and anti-diabetic
actions are being studied. Here we have carried out a systematic review of Callicarpa macrophyllus
documenting all its references in ancient texts and modern scientific studies.

Key words: Priyangu, Callicarpa macrophylla, Charak Samhita, Bhavprakash Nighantu, Dhanvantari
Nighantu.

INTRODUCTION effects on various ailments. Priyangu means ‘one who

In this era of modern medicine and scientific research, is dear’ or ‘liked by all’. Three different herbs have
traditionally used medicines in various indigenous been used as Priyangu, but Callicarpa macrophylla is
systems of medicine are increasingly being the most accepted and widely used, others being
researched. They are rightfully gaining their deserved Prunus mahaleb and Aglaia roxburghiana. Further, we
place in the armamentarium of the modern physician. have reviewed the literature for all the studies that
One such medicinal plant which has plenty of have been carried out on it in the modern context.
prescribed uses in the classical Ayurvedic texts, and We have compiled its phytochemistry, mechanism of
has been studied scientifically, is Priyangu. Here we action and explained all its uses and effects in a
make a systematic effort to study and compile all the modern scientific context.
references to it in various Samhitas and Nighantus. AIMS AND OBJECTIVES
We have studied its descriptions, prescribed uses and
1. A complete literary review of all the references to
Address for correspondence:
Dr. Monika Paprikar Priyangu in classic Ayurvedic texts like Charak
Associate Professor, Dept of Dravyaguna, Ashvin Rural Ayurved Samhita and Nighantus.
College and Hospital, Manchi Hills, Sangamner, Maharashtra,
India. 2. Review of literature analyzing all the studies
E-mail: [email protected] carried out on Callicarpa macrophylla, studying its
Submission Date: 12/09/2021 Accepted Date: 17/10/2021
Access this article online phytochemistry, mechanism of action,
Quick Response Code identification of active metabolites and clinical
Website: www.jaims.in research trials.

METHODOLOGY
Published by Maharshi Charaka
Ayurveda Organization, Vijayapur, 1. A complete search of Charak Samhita was done
Karnataka (Regd) under the license CC- and analysed for all the references to Priyangu.
by-NC-SA

Journal of Ayurveda and Integrated Medical Sciences | Sept - Oct 2021 | Vol. 6 | Issue 5 227
 Monika Paprikar et al. Systematic review of Priyangu (Callicarpa macrophylla)

ISSN: 2456-3110 REVIEW ARTICLE Sept-Oct 2021

2. Bhavprakash and Dhanvantari Nighantus were In Charak Samhita, it is mainly recommended in

studied for all references to Priyangu. bleeding disorders (Raktapitta). It is also
Gunakarmatmak Adhyayan (mechanism of action) recommended in disorders related to vitiated pitta
of Priyangu was done based on it. and in patients with Pitta Prakriti.[3] In antenatal care,
use of Priyangu is recommended mainly for its
3. We searched PubMed, Google scholar, Research
antiseptic activity.
gate, Science gate and other internet resources
for all the published papers about Callicarpa In Ashtanga Hrudaya, it is recommended for stopping
macrophylla. A systematic review of literature of excessive bleeding. It can also be used in chronic
all the published data was carried out. diahorrea and Pittaja disorders. It helps in healing
fractures and wounds.[4]
Charak Samhita Bhavprakash Dhanvantari As per Bhavprakash Nighantu, it is recommended for
Nighantu Nighantu
treatment of dysentry (Raktatisara), fever (Jwara),
Raktapitta Raktatisaar Chardi excessive sweating, burning sensation of the body
(Daha), body odour (Durgandha) and tumors
Pittaj Kushtha Daha Daha (Gulma).[5]
Arsha Sweda Jwara In Dhanvantari Nighantu, it is recommended to be
used in delerium (Moha), burning sensation of the
Raktatisaar Jwara Moha
body (Daha), fever (Jwara), vomiting (Chardi) and
Visha Durgandha Raktapitta bleeding disorders (Raktapitta).[6]

Dantamukha Roga - - As per various Nighantus, its Rasa Panchak is as

follows:
Description of Priyangu in ancient texts
▪ Rasa - Kashaya, Tikta
Priyangu has been extensively studied and finds
references in various ancient texts. According to the ▪ Virya - Sheeta
descriptions found in Nighantus and Samhitas, ▪ Vipaka - Katu
Priyangu is a climber or a shrub. Its flowers have
sweet aroma and the plant looks very beautiful in the ▪ Guna - Guru, Ruksha
flowering season. It is appropriately called ▪ Doshaghanata - Pittashamak
‘Mahilapriya’, as it attracts females.[1]
As per Bhavprakash Nighantu, its fruits and flowers
In Charak Samhita, it is included in Sandhaniya are used for preparing various treatment
Mahakashaya, Purishasangrahaniya Mahakashaya, formulations. It can be used either in a powdered
Mutravirajaniya Mahakashaya, Prajasthpana form or as a decoction. Oil prepared from it, called
Mahakashaya and Shonitasthapana Mahakashaya.[2] Priyangvadi Taila, is recommended to be applied
Priyangu is mentioned in Pittashamak (pacifies externally on the wounds. Priyangu flowers are
vitiated Pitta) Dravyas. We have come across a total recommended to be used for syrup (Asava)
of fifty-eight references of Priyangu in Charak preparations as per Charak Samhita.
Samhita, of which thirty-one pertain to blood
Taxonomy
disorders (Raktapradoshaja Vikara).
Three different plants have been used as Priyangu in
In Bhavprakash Nighantu, two varieties of Priyangu
different parts of India:
are described: 1. Priyangu. 2. Gandha Priyangu. it is
included in Karpooradi Varga. In Dhanwantari ▪ Callicarpa macrophylla Vahl.
Nighantu, it is mentioned in Chandanadi Varga. ▪ Prunus mahaleb Linn.

Journal of Ayurveda and Integrated Medical Sciences | Sept - Oct 2021 | Vol. 6 | Issue 5 228
 Monika Paprikar et al. Systematic review of Priyangu (Callicarpa macrophylla)

ISSN: 2456-3110 REVIEW ARTICLE Sept-Oct 2021

▪ Aglaia roxburghiana Miq. and Nepal. In India, it is found up to an altitude of

1800 meters, in Jammu & Kashmir, Himachal Pradesh,
After taking into consideration the descriptions found
Uttar Pradesh, Bihar, Sikkim, West Bengal, Arunachal
in Samhitas and Nighantus, it is seen that the most
Pradesh, Assam, Meghalaya, Nagaland, Manipur,
popular and likely herb that has been used as
Mizoram, Tripura and Andhra Pradesh.
Priyangu is Callicarpa macrophylla. As per
descriptions in Bhavprakash Nighantu, Prunus Phytochemistry
mahaleb qualifies as Gandha Priyangu.[7] Aglaia
Mahesh Chandra et al. studied essential oils from
roxburghiana is a tree and does not ideally qualify as
three different aerial parts and analysed them by GC-
Priyangu.
MS. Over 51, 53, and 40 compounds were identified in
Scientific classification of Callicarpa macrophylla C. macrophylla leaves essential oil (CMLEO), C.
macrophylla pre mature seeds and fruits essential oil
Kingdom Plantae
(CMEO-I) and C.macrophylla mature seeds and fruits
Division Angiospermae
essential oil (CMEO-II), respectively. These oils differ
in relative contents of major compounds viz; β-
Order Lamiales selinene (37.51% in CMLEO, 44.66% in CMEO-I and
57.01% in CMEO-II), phyllocladene (9.76% in CMLEO,
Family Verbanaceae
5.80% in CMEO-I and 12.38% in CMEO-II),
Class Dicotyledons caryophelline oxide (7.34% in CMLEO, 8.74% in CMEO-
I and 5.0% in CMEO-II), 9E-epi-caryophelline (6.23% in
Genus Callicarpa CMLEO, 1.27% in CMEO-I and 3.43% in CMEO-II),
longipinocarvone (4.96% in CMLEO, 1.17% in CMEO-I
Species Macrophylla
and 2.0% in CMEO-II), and 1,8-cineole (2.23% in
Description CMLEO, 3.10% in CMEO-I and 1.62% in CMEO-II).[9]

Callicarpa macrophylla is an erect shrub about 3-5 m According to Chatterjee et al, 1972, two tetracyclic
high. Its stem and branches are densely covered with diterpenes, calliterpenone and calliterpenone
a greyish tomentum of stellate hairs. monoacetate have been isolated from the petrol
extract of the aerial parts.[10]
Leaves are elliptic-oblong to lanceolate, 10-35 cm
long, 2-18 cm broad, mature glabrescent and rugose Ursolic acid, β- sitosterol and 5,4′-dihydroxy 3'-7-3′-
above or with numerous stubble-like small hairs, trimethoxy flavone have been isolated from the
densely greyish-white stellate-tomentose beneath; petroleum ether extract of leaves.[11] Methanol
petiole 4-12 mm long, densely floccose-tomentose. extract of the deposit of the water extract obtained
after distillation of the essential oil of the leaves
The inflorescence is densely stellate-hairy; primary
yielded 16α,17-isopropylideno-3-oxo-phyllocladane
peduncles equal to or a little longer than the petioles,
(isopropylidenocalliterpenone) along with
1-2.5 cm long. Flowers are on short, slender pedicels; [12]
calliterpenone and its monoacetate.
pedicel gland-dotted, tomentose.
C. macrophylla leaves contain α-amyrenol, α-amyrin,
Fruit is globular, ± 2 mm in diameter, glabrous,
ursolic acid, 2α, 3α, 19α-trihydroxy -12-dien-28-ursolic
glandular, smooth, white. It flowers from May to
acid, betulinic acid, β-sitosterol, daucosterol;[13]
August and fruits from September to February.[8]
flavanoids such as luteolin, apigenin, luteolin-7-O-
Distribution glucuronide, apigenin-7-O-glucuronide, β-sitosterol-β-
Globally, Callicarpa macrophylla is widely distributed D-glucoside, 2α-hydroxy ursolic acid, crategolic acid,
across India, China, Bhutan, Myanmar, South East Asia docosanoic acid, tricosanoic acid, tetracosanoic acid,

Journal of Ayurveda and Integrated Medical Sciences | Sept - Oct 2021 | Vol. 6 | Issue 5 229
 Monika Paprikar et al. Systematic review of Priyangu (Callicarpa macrophylla)

ISSN: 2456-3110 REVIEW ARTICLE Sept-Oct 2021

ethyl tricosanoate, 3,7,3′-trimethoxy- 4′, 5- 2. Analgesic activity

dihydroxyflavone.[14,15]
The effects and actions of Callicarpa macrophylla have
The bark contains betulinic acid. The roots and aerial shown promising results in studies carried out in
part contain essential oil, (diterpene) calliterpenone, animals. Aqueous as well as ethanolic extracts of its
calliterpenone monoacetate. Seeds contains roots (at two concentrations 200 & 400 mg/kg) were
calliterpenone, calliterpenone-17-acetate, oleanolic evaluated for its analgesic and anti-inflammatory
acid.[16] potentials using tail immersion test and carrageenan
paw edema method in albino rats respectively by
Pharmacological activities Yadav et al, 2012. A significant reduction of the
Priyangu is Kashaya, Tikta Rasatamaka, Sheeta painful sensation due to tail immersion in warm water
Viryatamaka, Vatapittashamaka and Sandhaniya so it was observed followed oral administration of the
is used in bleeding disorders (Raktapitta). Being tikta ethanolic and aqueous extract at dose of 200,
Rasatmaka and Sheeta Viryatmaka it is useful in 400mg/kg of leaves and roots of Callicarpa
burning sensation in body (Daha), fever (Jwara), macrophylla Vahl. The effect was found to be dose
excessive thirst (Trushna). Being purish Sangrahaniya dependent. In this model, higher dose of the aqueous
(absorbent) it is useful in dysentry (Raktatisara) and extract (400mg/kg) at an interval of 60 min has
bleeding disorders (Raktapitta). Being Pittashamaka, exhibited better analgesic activity than the standard
Priyangu is recommended in excessive sweating and drug.[19]
body odour (dourgandhya). Being sandhaniya it helps Several flavonoids isolated from medicinal plant have
in healing wounds (Vrana Ropana). been discovered to possess significant analgesic
1. Anti-bacterial activity effects.[20] The analgesic activity of ethanolic, aqueous
extract of roots of Callicarpa macrophylla Vahl. may
Many studies have been done to study the be due to the presence of flavonoids compound.
antibacterial activity of extracts and preparations of
3. Anti-Inflammatory Activity
Callicarpa macrophylla. Yadav et al studied ex vivo
antibacterial activity of ethanolic (SEE) and aqueous The ethanolic and aqueous extracts (200 mg/kg, 400
(SAE) stem bark extracts of Callicarpa macrophylla mg /kg) of leaves of Callicarpa macrophylla showed
against gram positive and gram negative strains using significant (p< 0.05) anti- inflammatory effect in the
Kirby bauer agar disc diffusion assay techniques. SEE, acute phase of the inflammation process as compared
showed moderate growth inhibitory activity against with standard drug, Diclofenac sodium (20 mg/kg
all the bacterial strains, but SAE was exceptionally body wt). Further, the ethanolic and aqueous extracts
inactive against all strains except Salmonella were found to contain carbohydrates, steroids,
typhimurium.[17] flavonoids and tannins, through preliminary
photochemical screening. The anti-inflammatory
Rubaiyat Islam Mona studied cytotoxic and
activity may be due to one/more group of above
antibacterial activity of methanol extract of Callicarpa
Phytoconstituents which may cause inhibition of
macrophylla leaves. The highest (92%) cells growth
histamine, serotonin or prostaglandin synthesis.[21]
inhibition occurred at the 2.5 mg/mL concentration
and maximum zone of inhibition (22 mm) was found 4. Anti-Arthritic Activity
against Bacillus cereus bacterial strain at the highest Anti-arthritic effect of Callicarpa macrophylla was
concentration of 350 μg/disc. It demonstrated that studied by testing various in-vitro parameters like
the methanolic extract of Callicarpa macrophylla protein denaturation and membrane stabilization by
leaves have potent cytotoxic but moderate Gupta et al. at different dose levels (50, 100, 200, 400
antibacterial activity.[18] and 800 g/ml). They concluded that it provided

Journal of Ayurveda and Integrated Medical Sciences | Sept - Oct 2021 | Vol. 6 | Issue 5 230
 Monika Paprikar et al. Systematic review of Priyangu (Callicarpa macrophylla)

ISSN: 2456-3110 REVIEW ARTICLE Sept-Oct 2021

significant protection against denaturation of proteins for 10 days to develop insulin resistance. The blood
and hypotonic saline induced RBC membrane glucose level, body weight and lipid profile were
damage.[22] estimated. The blood glucose level decreases
gradually in the animals treated with Callicarpa
Denaturation of tissue proteins is one of the well
macrophylla flower extract (100 mg/kg b.w. and 200
documented causes of inflammatory and arthritic
mg/kg b.w., orally) and the antidiabetic effect was
diseases. Production of auto-antigens in certain
compared with that of Glibenclamide 1 mg/kg p.o., to
arthritic diseases may be due to denaturation of
conclude with the results that Callicarpa macrophylla
proteins in vivo.[23, 24]
shows antidiabetic activity in dexamethasone
5. Antifungal Activity model.[27]
YC Tripathi et al., 2017 studied aqueous extracts of 7. Hepatoprotctive Activity
leaves of Callicarpa macrophylla Vahl. for antifungal
Hepatoprotective activity of extract was studied in
efficacy against six pathogenic fungi namely viz,
Albino rats against Paracetamol (3 g/kg b.w./p.o. 3
Alternaria alternata, Aspergillus flavus, Aspergillus
days) and carbon tetrachloride (2 ml/kg, b.w. /s.c. 4
niger, Cladosporium cladosporidies, Drechslera
days) induced hepatotoxicity. Standard drug was used
halodes and Fusarium moniliforme by agar-well
for hepatoprotection (Silymarin 25 mg/kg, b.w./p.o.).
diffusion method. Aqueous extract of Callicarpa
Treatment of animal with hydro-alcoholic extract of
macrophylla leaves exhibited varying degrees of
aerial parts of Callicarpa macrophylla significantly (p <
antifungal activity against all the six test fungi. Radial
0.05) decreased the levels of SGOT in serum which is
growth inhibition of fungi at concentration of 5, 10, 20
an indicative of hepatoprotective activity. Also
and 30 mg/ml was much less than that of positive
brought down was the level of serum glutamic pyruvic
control. However, 40 and 50 mg/ml test
transaminase (SGPT) significantly (p < 0.05 in 200
concentration of extract was considerably effective on
mg/kg b.w. and p < 0.01 in 100 mg/kg b.w. doses).
growth inhibition of all the test fungi. Test
Other than these parameters level of Bilirubin (Total
concentration of 50mg/ml showed growth inhibition
and Direct) and histopathological studies also was
almost at par with synthetic fungicide Carbendazim
indicative of hepatoprotective property of the plant
taken as positive control.[25]
extract. In conclusion, it is observed that hydro-
Another study was carried out by Yadav et al., 2012 alcoholic extract of aerial parts of Callicarpa
for antifungal activity of ethanolic and aqueous macrophylla possess hepatoprotective property which
extracts of the stems of C. macrophylla Vahl. Agar disc was evident by biochemical parameters and
diffusion method was adopted for the antifungal histopathological reports.[28]
screening against seven fungal strains. The ethanolic
Presence of flavonoids in hydro-alcoholic extract of
extract of stem exhibited antifungal activity against six
aerial parts of Callicarpa macrophylla may be a factor
strains in both 200 μg/disc and 400 μg/disc
to contribute antihepatotoxicity ability through
concentration. The largest zone of inhibition (17 mm
inhibition of cytochrome P-450 aromatase.[29]
in diameter) was recorded against G. fujikoroi but
aqueous extract did not exhibit any antifungal 8. Cytotoxic, acute toxicity and phytotoxic activity
activity.[26]
The study describes the cytotoxic, acute toxicity and
6. Antidiabetic Activity phytotoxic activities of Callicarpa macrophylla. Brine
shrimps cytotoxic bioassay of crude extract of bark of
The study of the antidiabetic activity of the flower
Callicarpa macrophylla (CBE) showed 975.22 LD50
extract of Callicarpa macrophylla was investigated in
value and crude extract of leaves of Callicarpa
dexamethasone-induced diabetic rats. Rats were
macrophylla (CLE) showed no significant results.
treated with dexamethasone at a dose of 5 mg/kg s.c.
However, all the test animals were found absolutely
Journal of Ayurveda and Integrated Medical Sciences | Sept - Oct 2021 | Vol. 6 | Issue 5 231
 Monika Paprikar et al. Systematic review of Priyangu (Callicarpa macrophylla)

ISSN: 2456-3110 REVIEW ARTICLE Sept-Oct 2021

safe in acute toxicity test. In phytotoxic assay against This study will prove beneficial for further clinical
Lemna minor, CLE showed FI50 value of 464.55 and research.
CBE showed no significant results. In conclusion, the
CLE showed significant phytotoxic activity and
REFERENCES
therefore, could be a useful natural herbicidal. 1. Chunekar K, Pandeya G, [ed.]. Bhavprakash Nighantu.
Varanasi: Chaukhamba Bharti Academy, reprint, 2006. p 248
When the crude extract of barks and laves of the plant shloka 101.
was tested in brine shrimp cytotoxic assay, no such
2. Shastri, Kashinath and Chaturvedi, Gorakhnath, [ed.]. Charak
anticancer potential was observed and thus ruled out Samhita. Lucknow: Chaukhamba Bharti Academy, 1996.
the presence of anticancer constituents in the extracts Sutrasthana 4.
of both leaves and barks of the plant. Additionally, the 3. Shastri, Kashinath and Chaturvedi, Gorakhnath, [ed.]. Charak
extracts of both leaves and barks of the plant neither Samhita. Lucknow: Chaukhamba Bharti Academy, 1996.
impart any change in animal behavior in acute toxicity Vimansthana 6/17.
test nor caused any mortality and thus was found 4. Ganesh Garde. Sarth Vagbhat. Pune: Gajanan Book Depot, 7th
absolutely safe during 24h assessment times. edition, 1983. Sutrasthana 15/7.

5. Chunekar K, Pandeya G, [ed.]. Bhavprakash Nighantu.

The crude methanolic extract of both leaves and bark
Varanasi: Chaukhamba Bharti Academy, reprint, 2006. p 248
of Callicarpa macrophylla exhibited absolute safety in shloka 102-103.
both in-vitro and in-vivo models with significant
6. Ozha J, Mishr U, [ed.]. Dhanvantari Nighantu. Delhi:
phytotoxicity in concentration dependent manner.[30]
Chaukhamba Sanskrit Pratishthana, 2004. p 125 shloka 16.

CONCLUSION 7. Chunekar K, Pandeya G, [ed.]. Bhavprakash Nighantu.

Varanasi: Chaukhamba Bharti Academy, reprint, 2006. p 248
Priyangu or Callicarpa macrophylla has many shloka 103.
references both in Charak Samhita and various
8. Leeratiwond C, Chantaranothai P, Paton AJ. A synopsis of the
Nighantus. It is widely distributed in India and is genus Callicarpa L. (Lamiaceae) in Thailand. Thai Forest Bull.,
readily available. As per Ayurveda, it is Shrestha Bot. 2009; 37:36-58. https://li01.tci-
Hitakara Dravya for Raktapitta. It is Kashaya, Tikta thaijo.org/index.php/ThaiForestBulletin/article/view/24334

Rasatamaka, Sheeta Viryatamaka, Vatapittashamaka, 9. Chandra M, Prakash O, Kumar R, Bachheti RK, Bhushan B,
Sandhaniya and Purishasangrahaniya and so it is used Kumar M, Pant AK. β-Selinene-Rich Essential Oils from the
parts of Callicarpa macrophylla and their antioxidant and
in Raktaja and Pittaja Vikara. It can be used in the
pharmacological activities. Medicines. 2017;
form of Bahya and Abhyantar Kalpanas. Scientific 4(3):52. https://doi.org/10.3390/medicines4030052
research is being done extensively on Callicarpa
10. Chatterjee A, Desmukh SK, Chandrasekharan S, Diterpenoid
macrophylla. As seen in our review of literature, constituents of Callicarpa macrophylla vahl: The sturctures
studies have been done to isolate its active and stereochemistry of calliterpenone and calliterpenone
ingredients. Number of studies have documented the monoacetate, Tetrahedron. 1972, 28(16): 4319-4323.
action of extracts of its flowers, stem, leaves and https://doi.org/10.1016/S0040-4020(01)88954-7.

other aerial parts. It is seen to have anti- 11. Chaudhary A, Bhattacharya A, Mitra SR, & Adityachaudhary
inflammatory, analgesic, antibacterial, antifungal, N. Phytochemical investigation on the leaves of Callicarpa
macrophylla Vahl. J Indian Chem Soc. 1978; 55:628–629.
hepato-protective as well as antidiabetic properties.
These effects seem to collaborate in some ways with 12. Singh AK, Agrawal PK. 16α, 17-Isopropylideno-3-oxo-
phyllocladane, a diterpenoid from Callicarpa macrophylla.
the way the drug has been prescribed to be used in
Phytochemistry. 1994; 37:587–588. doi: 10.1016/0031-
Ayurveda. Most of the studies that have been done 9422(94)85106–9.
are on animal subjects. Human trials need to be
13. Ping P and Qi-shi S: Chemical constituents of Callicarpa
conducted for validating its use in modern medicine. macrophylla Vahl. Journal Shenyang Pharma University 2006;
The studies are promising and Callicarpa macrophylla 09.
holds a lot of potential for research and clinical use.

Journal of Ayurveda and Integrated Medical Sciences | Sept - Oct 2021 | Vol. 6 | Issue 5 232
 Monika Paprikar et al. Systematic review of Priyangu (Callicarpa macrophylla)

ISSN: 2456-3110 REVIEW ARTICLE Sept-Oct 2021

14. Subramanian S and Ramachandran SAG: Terpenoids and 24. Umapathy E, Ndebia EJ, Meeme A, Adam B, Menziwa P,
flavones of Callicarpa macrophylla and Callicarpa longifolia. J Nkeh-Chungag, Iputo JE. An experimental evaluation of
Phytochem. 1974; 13: 306-307. Albuca setosa aqueous extract on membrane stabilization,
protein denaturation and white blood cell migration during
15. Xiao-rong L, Ri-bao Z, Li-jun T, Qiao-zhen T, Xiang-dan L and
acute inflammation. Journal of Medicinal Plants Research.
Jia-sheng L: Research of total flavone content in Callicarpa
2010; 4(9):789-795.
macrophylla Vahl. in different harvest time. J Trad Chinese
Med Univ Human. 2010; 11. 25. Tripathi YC, Nishat A, Lokesh U. In vitro Evaluation of
Antifungal Activity of Callicarpa macrophylla Vahl Leaves .
16. Verma RK, Singh AK, Srivastava P, Shanker K, Kalra A and
Organic & Medicinal Chem IJ. 2017; 1(5): 555571. DOI:
Gupta MM: Determination of novel plant growth promoting
10.19080/OMCIJ.2017.01.555571.
diterpenes in Callicarpa macrophylla by HPLC and HPTLC. J
Liq Chroma Rela Techno. 2009; 32(16): 2437-2450. 26. Yadav V, Jayalakshmi S, Singla RK and Patra A: Ex vivo
screening of stem extracts of Callicarpa macrophylla Vahl for
17. Yadav V, Jayalakshmi S, Singla RK, Patra A. Evaluation of
antifungal activity. Indo Global J Pharma Sci. 2012; 2(2): 103-
antibacterial activity of Callicarpa macrophylla Vahl stem
107.
extracts. Webmed Central Ayur Med. 2012; 3(8):
WMC003651. 27. Anil kumar K V etal., Antidiabetic activity of Callicarpa
Macrophylla flower extract by Dexamethasone Induced
18. Mona RI. Investigation of cytotoxic and antibacterial activity
Insulin resistance. Int. Pharmsciencia. 2013; 3(1): 70-83.
of methanol extract of callicarpa macrophylla leaves. BRAC
University project report. 2016. 28. Ramesh P, Talha Jawaid. Hepatoprotective activity of aerial
parts of plant extract of Callicarpa macrophylla in rats.
19. Yadav V, Jayalakshmi S, Patra A and Singla RK: Investigation
Pharmacy and Pharmacology Research. April 2014; 2(1): 1-8.
of analgesic & anti pyretic potentials of Callicarpa
macrophylla Vahl leaves extracts. Webmed Central: 29. Kukongviriyapan V, Janyacharoen T, Kukongviriyapan U,
International Journal Med Mole Med. 2012; 3(6): Laupattarakasaem P, Kanokmedhakul S, Chantaranothai P,.
WMC003447. Hepatoprotective and antioxident activities of Tetracera
loureiri. Phytother Res. 2003; 17:717-721.
20. Gülnur Toker, Esra Küpeli, Merve Memisoğlu, Erdem Yesilada.
Flavonoids with antinociceptive and anti-inflammatory 30. Barkatullah, Muhammad Ibrar, Muhammad Nafees, Abdur
activities from the leaves of Tilia argentea (silver linden). Rauf, Haroon Khan. Cytotoxic, Acute Toxicity and Phytotoxic
Journal of Ethnopharmacology. 2004; 95(2-3), 393-397. Activity of Callicarpa macrophylla in Various Models.
https://doi.org/10.1016/j.jep.2004.08.008. American Journal of Biomedical and Life Sciences. Special
Issue: Phytochemical and Pharmacological Study of Medicinal
21. Yadav V, Jayalakshmi S, Singla RK and Patra A: Preliminary
Plants. 2015; 3(2-1), 1-4. doi:
assessment of the anti-inflammatory activity of Callicarpa
10.11648/j.ajbls.s.2015030201.11
macrophylla Vahl. leaves extracts. Indo Global J Pharma Sci.
2011; 1(3): 219-222.
How to cite this article: Monika Paprikar, Manoj
22. Santosh Kumar Gupta, Amit Gupta, Gupta AK, Dhirendra Paprikar. Systematic review of Priyangu (Callicarpa
Pakash, Vedpal. In vitro Anti-arthritic activity of ethanolic
macrophylla). J Ayurveda Integr Med Sci 2021;5:227-
extract of Callicarpa macrophylla flower. Int. Res. J. Pharm.
2013; 4(3):160-162.
233.

23. Opie EL. On the relation of necrosis and inflammation to Source of Support: Nil, Conflict of Interest: None
denaturation of proteins. J Exp Med. 1962;115(3):597-608. declared.
doi:10.1084/jem.115.3.597

*******************************

Copyright © 2021 The Author(s); Published by Maharshi Charaka Ayurveda Organization, Vijayapur (Regd). This is an open-access article distributed under the
terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc-sa/4.0), which permits unrestricted use, distribution, and
perform the work and make derivative works based on it only for non-commercial purposes, provided the original work is properly cited.

Journal of Ayurveda and Integrated Medical Sciences | Sept - Oct 2021 | Vol. 6 | Issue 5 233