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    Receptor Mechanisms

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    nawafalghamdi20

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    © All Rights Reserved
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    Receptor Mechanisms

    Uploaded by

    nawafalghamdi20
    3 views2 pages

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    Copyright:

    © All Rights Reserved
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    3 views2 pages

    Receptor Mechanisms

    Uploaded by

    nawafalghamdi20

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 2

    Receptor Mechanisms

    2. G-protein-Coupled
    Receptors(GPCR)

    Fastest 1. Ligand-gated ion


    channels
    Binding of agonist in GPCR

    Activaiton of GPCR

    Activated by binding of
    a ligand(Agonist) to G-protein activation
    receptor on the
    channel molecule

    G-GDP to G-GTP

    Activiation or Inhibition of enzyme


    Binding causes with subsequent modification of
    second messengers ex: cAMP,IP3
    conformational change
    in the receptor which
    leads to ion channel Biological effect or opening or
    opening closing of ion channel
    3. Kinase-linked Receptors, 3. Kinase-linked Receptors,
    Growth Factor Receptors
    Cytokine Receptors
    4. Intracellular Receptors (Nuclear
    Slowest Receptors)
    Growth Factor binds to
    receptor
    Cytokine binds to receptor
    Dimerization and hsp90 protien binds to
    autophosphorylation of
    receptor
    glucocorticoid receptor
    Dimerization of receptor
    Grb2 and Sos adapter
    proteins binds to receptor

    hsp90 causes deactivation


    Binding of Jak
    Activation of Ras GDP/GTP
    exchange

    Activation of Raf
    Activation(phosphorylation)
    of receptor and Jak binding of hormone steroid causes
    dissociation(removal) of hsp90
    Activation of Mek
    Binding of Stat

    Activation of MAP Kinase


    Glucocorticoid receptor becomes
    active
    Dimerization of Stat
    Activates various
    transcription factors

    Gene transcription Gene transcription


    Gene transcription

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