Ex Exbc

EXBC - EXAMPLE XXXXXXXXXX ______________________________
Min 24 p / max 40 p MCQ (multiple choice questions) Name, Surname
1. Fluoroacetate is a substance isolated from some plants. It is metabolised into florocitrate, a potent
competitive inhibitor of enzyme aconitase (Citric Acid Cycle enzyme).
Line 1 indicates activity of aconitase without fluoroacetate. Two lines show the activity of the same
enzyme, one in the low concentration and one in the high concentration of fluoroacetate. Circle the number of line showing
the presence of high concentrations of fluoroacetate.
4p
2. Combine the statements with appropriate amino acids (AA). 8p-1
In colllagen (functional form) must be hydroxylated
Without optical activity
Can cause kidney stones with S-S bonds
Regulatory place for protein kinases
Essential for cooperativness of hemoglobin
GLYCINE LYSINE ALANINE SERINE THREONINE

HISTIDINE PROLINE CYSTEINE LEUCINE THRYPTOPHANE
3. Circle the correct statements for IRON:
a. in the functional hemoglobin structure must be 2+

b. in the structure of proline and lysyl hydroxylase must be 3+ if the enzyme is functional
c. in the cytochrome structure must be reduced (2+) all the time 6p-1
d. excess of iron is removed from the body by bilirubin
e. vitamin C prevents oxidation of iron in proline and lysyl hydroxylase
f. if iron in hemoglobin structure is oxidized- this form is called methemoglobin
6p
The peptide sequence of clotting factor VII is shown.
4. Mark the posttranslational modification needed for the propper function of the protein in the
process of coagulation.
Name at least 2 of aminoacids that are incorporated in the protein sequence.
 5. Oxidative deamination is the liberation of free ammonia from the amino group of aminoacids coupled
with. This takes place mostly in liver and kidney. The purpose of oxidative deamination is to provide NH3 for
urea synthesis and α-keto acids for a variety of reactions, including energy.
How many total ATPs can be generated by the complete oxidation of the carbon skeleton of
a. Serine (becomes pyruvate) and b. Glutamate (becomes alpha-ketoglutarate)
________ATP ________ATP

6. Mark with A the anaplerotic reaction.
7. Mark wit HB the start point for hemoglobin synthesis.
8. Mark with G the intermediate of CAC which deficiency cause the intense synthesys of ketone bodies.
9. Show the structures of the missing intermediates of Krebs Cycle. 6p
10. Mark with UC the intermediate that connects the Urea cycle and CAC. 4x2p=8p
16. 11. Write the name of the control enzyme of the Urea cycle (at the correct reaction). 2p
17. 12. High concentrations of ATP INHIBITS / ACTIVATES / HAVE NO EFFECT on the activity of
UC control enzyme. circle correct A
2p
13. Draw the structural formula of arginine, urea and ornitine to the correct positions.
14. Write the correct number of ATP, ADP or AMP needed for some of reactions. 4p
15. The urea cycle products are:
a. 1 urea, 1 ammonia, 1 ATP and 1 fumarate

b. 1 fumarate, 1 urea, 1 AMP, and 2 ADP
c. 1 aspartate, 1 ammonia, 1 fumarate, and 1 ATP
d. 1 molecule of carbamoyl phosphate if only 1 ATP is available 4p-1
e. H2O, 1 ADP and 1 AMP
Dra
Dr
16. Fill the gaps with: Q (ubiqinone), CYT (cytochrome), O2, H2O, ATP, ADP, Heat 7p
17. Which of the following statements about mitochondria is correct?
a) The outer mitochondrial membrane is extensively folded.

b) The mitochondrial matrix is filled with a concentrated solution of the glycolytic enzymes. 4p-1
c) The inner mitochondrial membrane is permeable because it contains pores.
d) The inner mitochondrial membrane is extensively folded.
e) The only way of ATP generation in all of the cells without mitochondria is glycolysis
18. In electron transport chain FADH2 its electrons ultimately pass to ____________________(the name of the electron
carrier). Explain the consequence from the aspect of ATP synthesis.
4p
19. Which of the following statements about the use of the NADPH generated from the pentose phosphate pathway is
correct?
a.NADPH generated from the pentose phosphate pathway is used for fatty acid synthesis
b.NADPH generated from the pentose phosphate pathway is used for the regeneration of glutathione to its reduced state.
c.The pentose phosphate pathway relies on the availability of NAD+.
d.The pentose phosphate pathway has an irreversible oxidative section and a reversible non oxidative section. 4p-1
e.Deficiency of glucose 6 dehydrogenase could result with increased oxydative stress in cells
20. What is thrue?

a. Adrenaline and glucagon stimulate fatty acid synthesis whereas insulin action is to counter the responses to these two
hormones, and conversely, to induce fat storage.
b. Adrenaline and glucagon stimulate fatty acid release from triglycerides stored in adipocyte fat droplets,
c. Insulin action is to counter the responses to adrenaline and conversely, to induce fat storage.
d. Lipase is connected with phosphate group if the concentration of adrenaline is high
e. Long-chain fatty acids must be activated in the cytoplasm before being oxidized in the mitochondria 4p-1

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Ex Exbc

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EXBC - EXAMPLE XXXXXXXXXX ______________________________

Min 24 p / max 40 p MCQ (multiple choice questions) Name, Surname

2. Combine the statements with appropriate amino acids (AA). 8p-1

In colllagen (functional form) must be hydroxylated

Without optical activity

Can cause kidney stones with S-S bonds

Regulatory place for protein kinases

Essential for cooperativness of hemoglobin

GLYCINE LYSINE ALANINE SERINE THREONINE

3. Circle the correct statements for IRON:

a. in the functional hemoglobin structure must be 2+

The peptide sequence of clotting factor VII is shown.

Name at least 2 of aminoacids that are incorporated in the protein sequence.

a. Serine (becomes pyruvate) and b. Glutamate (becomes alpha-ketoglutarate)

7. Mark wit HB the start point for hemoglobin synthesis.

9. Show the structures of the missing intermediates of Krebs Cycle. 6p

15. The urea cycle products are:

a. 1 urea, 1 ammonia, 1 ATP and 1 fumarate

a) The outer mitochondrial membrane is extensively folded.

20. What is thrue?

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