Microarrays

Powerfully efficient
cytogenetics analysis
Whole-genome hybrid-SNP array research solutions
 The map reflects the number of labs worldwide using
Applied Biosystems™
Cytoscan™ cytogenetics suite.

Expansive whole-genome
cytogenetics research
Advancements in cytogenetic technologies are providing
clinical researchers with powerful new approaches
to investigate chromosomal aberrations such as
copy number variations (CNVs), chromosomal
imbalances, and allelic imbalances. However, test
methods such as karyotyping, optical genome mapping
(OGM), whole-exome sequencing (WES), whole genome
sequencing (WGS), and low-resolution arrays each
have constraints that can lead to missed aberrations
and delays or increased costs. Microarrays that include
the latest available content for both polymorphic and
nonpolymorphic regions of the entire genome with
fast assays and artificial-intelligence (AI)-enabled variant
identification can overcome some of these limitations and
potentially boost discovery yield.

2
Contents
Boost efficiency and productivity in one
complete solution 4

Boost productivity with tailored

cytogenetic analysis 6
Constitutional applications 6
Oncology applications 8

Enhance efficiency with fully integrated

array processing 10
Chromosome Analysis Suite (ChAS) software 10

Product ordering information 11

3
Boost efficiency and productivity
in one complete solution
Complete chromosomal microarray (CMA) solution
for genome-wide copy number analysis
Identify aneuploidies, microdeletions, microduplications, and
other types of chromosomal aberrations across the genome
quickly and easily. The Applied Biosystems™ CytoScan™
arrays and Applied Biosystems™ OncoScan™ arrays offer a
highly reliable, consistent, and sensitive genome-wide
approach for high-resolution DNA copy number analysis.
Quickly detect gains and losses that may indicate loss of
heterozygosity (LOH), absence of heterozygosity (AOH),
copy-neutral loss of heterozygosity (cnLOH), uniparental
disomy (UPD), regions identical by descent, and mosaicism.

The complete CMA platform for cytogenetic analysis for research

includes arrays, fully kitted reagents, instrumentation, Applied Contact a Chromosome
Biosystems™ Chromosome Analysis Suite (ChAS) software, and Microarray specialist
Applied Biosystems™ CytoScan Automated Interpretation and
Reporting (AIR) solution.

Target preparation Array processing Scanning Data analysis

Flexible throughput DNA Automated array Fully integrated, automated Genome-wide view and
Flexible throughput Automated array Fully integrated, automated Genome-wide view and
amplification, fragmentation, hybridization, washing, array scanning analysis of chromosomal
DNA amplification, hybridization, washing, array scanning analysis of chromosomal
and labeling and staining aberrations, SNP variants,
fragmentation, a nd and staining aberrations, SNP variants,
and copy number
labeling and copy number
determinations
determinations

Figure 1. The robust workflow is aligned with your research laboratory workflow requirements, with intuitive processes to
streamline data analysis and reporting.

Minimize the complexity of Key features

• Enhanced evidence support with American College of
variant interpretation Medical Genetics and Genomics (ACMG) classifications,
phenotype matching, literature searches, and historical data
The CytoScan AIR solution combines ChAS and
Franklin (by Genoox) genetic data analysis software • Easy customization, reporting, evaluation, sign-off, and
to simplify genomic variant pathogenicity research laboratory information management system (LIMS) export
and reporting. Leverage AI for quick and precise • Evidence-based database development links evidence
variant identification, with rapid data interpretation and with observations
reporting in seconds.
• Access to over 350,000 shared variant classifications
and advanced findings from community-driven
cytogenetics research
4
All CytoScan arrays are hybrid-SNP CMAs that contain large numbers of both single nucleotide polymorphism
(SNP) probes and non-polymorphic probes. CytoScan Hybrid-SNP arrays provide more than 99% genotype
accuracy to boost confidence in breakpoint determination and enable independent confirmation of copy number
events throughout the entire genome.

Applied Biosystems microarrays for research applications in cytogenetics analysis

Prenatal Postnatal Liquid tumors Solid tumors

Fresh/Frozen FFPE
CytoScan Optima

CytoScan 750K

CytoScan HD

CytoScan HD Accel

OncoScan

CytoScan HT-CMA

CytoScan XON

Figure 2. Applied BioSystems microarrays enable a wide range of cytogenetics research application areas.

Hybrid-SNP arrays can detect these types of Download whitepapers:

genetic conditions[1] for research applications: Learn how high-resolution
• Suspected UPD, whole genome UPD, cnLOH, or AOH
SNP arrays detect inherited
• Mosaicism chromosomal anomalies
• Zygosity

• Consanguinity Cytogenetic research applications

Advances in human genetic analysis technologies can
• Parent of origin (requires parental genomic analysis)
potentially enable detection of certain causative DNA aberrations
• Twin-twin or maternal cell contamination associated with genetic disorders, thus helping provide valuable
• Allele-specific changes insights into chromosomal abnormalities in constitutional and
oncology samples.
• Sample heterogeneity, clonal diversity

• Genomic contamination • Prenatal genetic testing helps clinical researchers study

congenital anomalies or genetic disorders in the fetus.

SNP analyses are also used for: • Postnatal genetic testing helps clinical researchers study
• Breakpoint determination congenital anomalies, diseases, and developmental delays
following birth.
• Mendelian consistency checking
• Product of conception (POC) genetic testing of fetal tissue
• Confirmation of CNV events after the loss of a pregnancy helps clinical researchers study
chromosomal anomalies associated with miscarriage.

• Oncology genetic testing of tumor samples helps clinical

researchers study chromosomal aberrations associated
with cancer.

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Boost productivity with tailored
cytogenetic analysis

Constitutional applications
Select a CytoScan hybrid-SNP array that is tailored to your application
and detection sensitivity requirements. CytoScan assays feature Scientific spotlight:
Applied Biosystems GeneChip cartridge microarrays designed
™ ®
Learn why GeneDx, a leader
specifically for prenatal and postnatal research applications.
in testing for rare genetic
CytoScan arrays are manufactured using photolithography disorders, switched to high-resolution
technology, which produces arrays with very high batch-to-batch
whole-genome CMAs for prenatal
reproducibility without probe dropouts that are inherent in some
other array manufacturing techniques. and postnatal research applications.
• CMA is the recommended first line test by ACMG guidelines
and is used by the cytogenetics community worldwide[2,3]. “The hybrid SNP microarray
Detect chromosomal aberrations at high resolution with a
•
genome-wide, gene-centric design containing high density requires less DNA. This is
SNP and CNV probes.
especially good for buccal
• Analyze your data with the powerful and intuitive ChAS software
with enhanced analysis features, included free-of-charge. and uncultured prenatal
• Boost your discovery yield with the evidence-based CytoScan
AIR solution.
samples. We have been able
to reduce the amount of
Hybrid-SNP array: A practical approach to sample necessary by 40%.
complex problems in era of NGS

Dr. Catherine Rehder, Director

We see fewer inconclusive
Clinical Cytogenetics Laboratory, Duke University
results and fewer repeats
Determining the genetic cause of disease compared to our
by application of single exon array as a
complement to exome sequencing
Dr. Benjamin Hilton, Assistant Director
prior platform.
Cytogenetics Laboratory, Greenwood Genetic Center
This saves
Challenging microarray cases and the
approaches for analysis of unusual findings
GeneDx time,
Dr. Stuart Schwartz, Strategic Director, Cytogenetics
money, and
Women’s Health and Genetics, Labcorp
resources.”
Learn more about how hybrid-SNP
arrays are facilitating resolution to – Dr. Jeanne Meck,
unsolved clinical research questions Director, Cytogenetics and Prenatal
in prenatal and postnatal testing. Diagnostic Services, GeneDx

Watch the webinars

6
Table 1. CytoScan Suite specifications

CytoScan CytoScan CytoScan CytoScan CytoScan CytoScan

HD Accel HD 750K Optima HT-CMA XON

Research
applications

Fast turnaround High genome-wide High genome- Low-cost genome- High-throughput, Sensitive, high
with latest available resolution of CNVs wide resolution wide platform to cost-effective, coverage, whole
content for prenatal, for applications to analyze copy detect aneuploidies genome-wide copy genome, single
postnatal, and in prenatal and number gains and and copy number number analysis exon-level copy
oncology research postnatal research losses for prenatal losses and gains for constitutional number analysis.
and postnatal at lower resolution, cytogenetics Use as a stand-
research optimized for research and alone research
constitutional testing of relevant tool or to confirm
cytogenetics SNP variants CNV findings
research with alternative
technologies like
next generation
sequencing

Sample types Blood, buccal Blood, buccal Blood, buccal Blood, uncultured Blood, buccal Blood (Custom-
swabs, saliva, swabs, saliva, swabs, saliva, or cultured cells, swabs, saliva, built reference
uncultured or uncultured or uncultured or chorionic villi, uncultured file enables other
cultured cells, cultured cells, cultured cells, amniocytes, and or cultured cells, sources of DNA)
chorionic villi, chorionic villi, chorionic villi, POC chorionic villi,
amniocytes, POC, amniocytes, amniocytes, amniocytes,
and fresh, frozen, and POC and POC and POC
or FFPE tissue

Size of Losses: 25 kb Losses: 25 kb Losses: 100 kb Losses: 1 Mb Gains/losses 95% sensitivity to

aberration* (except for OMIM study exon-level
Gains: 50 kb Gains: 50 kb Gains: 400 kb Gains: 2 Mb
(analytical genes): 400 kb CNVs
LOH/AOH: 3 Mb LOH/AOH: 3 Mb LOH/AOH: 5 Mb AOH: > 5 Mb Gains/losses
claims) Whole genome
Mosaicism: >15% Mosaicism: >15% Mosaicism: Mosaicism: >20% (OMIM genes): coverage, with
(approximately) (approximately) >15%–20% (approximately) 100 kb increased coverage
(approximately) LOH/AOH: 3 Mb in 7,000 clinically
400 genes at
100 kb resolution relevant genes
Mosaicism:
>15%–20%

Input DNA 100 ng 10–250 ng** 10–250 ng** 10–250 ng** 100 ng 100 ng

Probe 2.8 million markers 2.67 million markers 750,000 markers Whole genome 750,000 markers 6.85 million
structure for whole genome for whole genome for whole genome coverage for whole genome empirically selected
coverage coverage coverage coverage probes for whole-
315,000 markers
genome coverage
2 million 1.95 million 550,000 covering control, 550,000
including:
nonpolymorphic nonpolymorphic nonpolymorphic CNV and SNP nonpolymorphic
markers markers markers probes markers 6.5 million copy
number probes
~750,000 SNP ~743,000 SNP ~200,000 SNP ~148,000 SNP ~200,000 SNP
probes for LOH/ probes for LOH/ probes for LOH probes for LOH probes for LOH ~300,000 SNP
AOH analysis, duo- AOH analysis, duo- analysis, duo-trio analysis, duo-trio analysis, duo-trio probes for LOH
trio assessment, trio assessment, assessment, and assessment, and assessment, and analysis, duo-trio
and sample and sample sample tracking sample tracking sample tracking. assessment, and
tracking tracking sample tracking
SNP probes for 178
variants across 36
genes

Protocol 2 days 3–4 days 3–4 days As little as 2.5 days 4 days 4 days

Click on
each icon to
download
datasheets

*Size of aberration—The size of the segment call depends on the average marker spacing in the region. Best performance can be achieved in regions with higher marker coverage. Mosaicism detection
may depend on the size of the altered segment and the type of aberration involved.
**250 ng is optimal but users have reported success using as little as 10 ng starting DNA.
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Oncology applications The new Applied Biosystems™ CytoScan™ HD Accel Array
Unlike constitutional applications of microarray analysis, which incorporates updated coverage in more than 5000 regions
are performed on whole blood samples, microarray analysis of as categorized by industry databases. The two-day assay
solid tumors is challenging because tumor tissues are typically workflow and lower input sample requirement help boost
formalin fixed and paraffin embedded (FFPE). laboratory efficiency.

CytoScan HD Suite for hematologic OncoScan assays for solid tumors research
malignancies research OncoScan assays are whole-genome copy number assays
Capture chromosomal abnormalities and genomic instability, designed to detect structural variants that are not well
which can be some of the most important aberrations in characterized by short-read sequencing or targeted sequencing.
tumors. The CytoScan HD Suite assay is designed with
Detect deletions, duplications, LOH, cnLOH, breakpoint
2.67 million markers for copy number analysis, facilitating
determination, ploidy, mosaicism, and unbalanced translocations
comprehensive coverage at the exceptional resolution so you
with Applied Biosystems™ OncoScan™ CNV assay and Applied
do not miss important aberrations.
Biosystems™ OncoScan™ CNV Plus Assay (previously known as
Applied Biosystems™ OncoScan™ FFPE Assay).

Key features boost productivity and efficiency

• Exceptional flexibility—detect chromosomal arm aberrations,
gains, losses, focal changes, LOH, and cnLOH in a single
assay, helping to reduce costs and processing times

• Comprehensive coverage—whole-genome analysis with

the latest content genes with established significance
in cancer and tumor progression as well as those with
Figure 3. CytoScan and OncoScan hybrid-SNP arrays enable emerging evidence
investigation of a wide range of solid (left) and liquid (right) tumors.
• Robust performance—obtain consistent results from
lot-to-lot and operator to operator

• Broad somatic mutation panel—covering 64 mutations in

9 genes (BRAF, EGFR, IDH1, IDH2, KRAS, NRAS, PIK3CA,

“CytoScan HD array PTEN, and TP53)

• Low sample input and fast results—get results in as little

analysis allows detection as two days from only 80 ng of FFPE-derived DNA

of copy number variations • Rapid analysis—included software provides intuitive data

visualization for hundreds of samples in minutes
and regions of copy-neutral • Evidence-based database development—link evidence with
observations for internal database management and expansion
loss of heterozygosity
• OncoScan CNV Plus Assay offers a high-resolution copy
across the genome during number detection in priority cancer genes—accurate
identification of very small (50–125 kb) to large (Mbs) CNVs
clinical research work-up of
hematologic neoplasms.” Learn how Dr. Madina
Sukhanova used
CMA combined
– Madina Sukhanova, PhD, with NGS assays to
FACMG, Assistant Professor identify and research
of Pathology, Northwestern genetic aberrations
University, Feinberg School associated with
of Medicine specific prognoses
in different types
of cancer.

Watch the webinar

8
 Download the Copy number state

whitepaper Weighted Log2 ratio

Allele difference
CytoScan HD Suite:
a comprehensive solution Smooth signal
for analyzing karyotypes in
hematological malignancies
Figure 4.
Chromothripsis
detected on
Log2 ratio chromosome 18
Watch now using CytoScan HD
arrays (top) and on
Allele difference chromosome 19
Webinar: Exploring the using OncoScan
genetic landscape of solid B allele frequency
arrays (bottom),
revealed by the
tumors using whole-genome sequential copy
number changes
copy number analysis and the multiple
breakpoints seen in
the different tracks.

Table 2. Suite specification for oncological clinical research sample profiling solutions

OncoScan CNV Assay CytoScan

CytoScan HD Suite
OncoScan CNV Plus Assay* HD Accel

Research application High resolution analysis of genome High resolution analysis, up to 50 kb in top Fast turnaround with latest
wide CNVs in liquid and solid tumors cancer genes and 300 kb across the whole available content for prenatal,
genome in FFPE and fresh frozen tissues postnatal, and oncology research

Sample types Blood, bone marrow, and fresh and FFPE, fresh and frozen tissue Blood, bone marrow, and fresh,
frozen tissue frozen, or FFPE tissue

Size of aberration** Gains: 50 kb Gains: 50 kb Losses: 25 kb

(analytical claims) Losses: 25 kb Losses: 50 kb Gains: 50 kb
LOH/AOH: 3 Mb LOH/AOH: 10 Mb LOH/AOH: 3 Mb
Mosaicism (% aberrant cells): >15% Mosaicism (% aberrant cells): 15%† Mosaicism: >15% (approximately)
(approximately)†

Input DNA 10-250 ng‡ 80 ng 100 ng

Probe structure 2.67 million markers for whole 220,000 molecular inversion probes (MIPs) 2.8 million markers for whole
genome coverage for whole genome coverage genome coverage
1.95 million nonpolymorphic markers 5,700 non-polymorphic probes 2 million nonpolymorphic markers
~743,000 SNP probes for LOH/AOH 216,000 SNP probes ~750,000 SNP probes for
analysis and sample tracking LOH/AOH analysis, duo-trio
assessment, and sample tracking

Protocol 3–4 days 2–3 days 2 days

Click on each
icon to download
product literature

*OncoScan CNV Plus Assay includes somatic mutation panel covering 64 mutations in 9 genes (BRAF, EGFR, IDH1 and 2, KRAS, NRAS, PIK3CA, PTEN, and TP53)
**Size of aberration—The size of the segment call depends on the average marker spacing in the region. Best performance can be achieved in regions with higher marker coverage. Mosaicism detection
may depend on the size of the altered segment and the type of aberration involved.
†Mosaicism in cancer is classified by % aberrant cells in the sample and is called in ChAS software.
‡250 ng is optimal but users have reported success using as little as 10 ng starting DNA.

9
Enhance efficiency with fully integrated
array processing

Streamline analysis,
interpretation, and reporting
for challenging genes
View and analyze chromosomal aberrations across the
genome, including copy number gain or loss, LOH, and
mosaicism. Developed with input from our customers and
leading experts, Applied BiosystemsTM Chromosome
The Applied Biosystems™ GeneChip™ System 3000 is a fully Analysis Suite (ChAS) software is designed
integrated platform to boost your research productivity using specifically for analysis and reporting in chromosomal
CytoScan or OncoScan arrays. aberration research. Enhanced, intuitive features simplify
cytogenetics investigation.
The GeneChip System 3000 combines advanced design and
automation to deliver high resolution scanning with minimized
Key features
hands-on time. This comprehensive system includes the Applied
• Whole-genome support for CytoScan Suite
Biosystems™ GeneChip™ Scanner 3000 7G, Applied Biosystems™
GeneChip™ Fluidics Station 450, Applied Biosystems™ GeneChip™ • CN state for CytoScan Suite
Hybridization Oven 645, and a powerful computer workstation • LIMS APIs
installed with instrument control software.
• Analyze data at different levels of resolution
The pre-assembled internal autoloader helps enable complete
• Automatically prioritize segmented data using scoring
walk-away freedom for scanning your arrays and supports more
inspired by the ACMG
efficient installation. The GeneChip Scanner 3000 7G uses a
solid-state laser so it needs no external laser power supply or • Customize and load your own annotations and regions for
focused analysis
special cooling system and fits easily into a laboratory benchtop.
Accurate gridding improves data integrity. Highly consistent • Store, query, and display historic sample data and
scanner-to-scanner performance facilitates data sharing annotations for streamlined analysis
among collaborators. • Directly access NCBI, UCSC Genome Browser, DECIPHER,
ClinVar, ClinGen, Ensembl, and OMIM databases and others
Highlights • Export user-selected data in formats like browser extensible
• Higher-resolution scanning from 0.51 to 2.5 μm pixels data (BED), Applied Biosystems™ Affymetrix™ extensible data
automatically selected by array type (AED), and variant call format (VCF) files
• Optimal image uniformity and collection efficiency • APIs to push and pull segment coordinates in and out of
across the entire scan area with proprietary Applied ChAS software
Biosystems™ Flying Objective™ Lens technology
• Automatic results file generation with zero manual
• Complete walk-away scanning of up to 48 arrays at set-up required
a time with pre-assembled autoloader

• Cost-effective approach enabling multiple assays on a

single flexible instrument View ChAS training
modules
• Compact size for better space utilization

• No laser drift and reduced scanner-to-scanner variability

Request a
• Automatic adjustments of residual arc correction
ChAS demo
and x-linearity

• Easier and safer operation with new scanner lid features

• Maximized longevity with updated internal components

10
 Routine-use
Laboratory Assay training Software
Planning Installation service
preparation and proficiency training
and support

Maximize your CytoScan expertise for greater at Thermo Fisher Scientific, including technical sales specialists,
laboratory efficiency field service engineers, field application scientists, and clinical
Our commitment to your success in cytogenetics research application consultants, support you with comprehensive
goes beyond tools and technologies. Leverage our support from initial planning to routine implementation.
comprehensive onboarding service and support offerings
for the CytoScan Suite solution to maximize your expertise
and minimize the time needed to ramp up your cytogenetics
Contact a Chromosome
research investigations. The team of experienced professionals
Microarray specialist

Ordering information
Product Description Cat. No
CytoScan HD Accel
CytoScan HD Accel Kit Plus 24 Arrays and reagents for 24 reactions with amplification kit 952465
CytoScan HD Accel Kit Plus 96 Arrays and reagents for 96 reactions with amplification kit 952466
CytoScan HD Accel Array Kit and Arrays and reagents sufficient for 24 reactions 952460
Reagent Kit Bundle
CytoScan HD Accel Training Kit Arrays and reagents sufficient for 24 reactions to perform 952461
assay training
CytoScan HD
CytoScan HD Kit Plus 24 Arrays and reagents sufficient for 24 reactions and CytoScan 905824
Amplification Kit sufficient for 96 reactions
CytoScan HD Kit Plus 96 Arrays and reagents sufficient for 96 reactions and CytoScan 905896
Amplification Kit sufficient for 96 reactions
CytoScan HD Array Kit and Reagent Arrays and reagent sufficient for 24 reactions plus training materials 901835
Kit Bundle
CytoScan HD Training Kit Arrays and reagent sufficient for 24 reactions plus training materials 901834
CytoScan 750K
CytoScan 750K Kit Plus 24 Arrays and reagents sufficient for 24 reactions and CytoScan 905924
Amplification Kit sufficient for 96 reactions
CytoScan 750K Kit Plus 96 Arrays and reagents sufficient for 96 reactions and CytoScan 905996
Amplification Kit sufficient for 96 reactions
CytoScan 750K Array and Reagent Arrays and reagent sufficient for 24 reactions 901859
Kit Bundle
CytoScan 750K Training Kit Arrays and reagent sufficient for 24 reactions plus training materials 901860
CytoScan Optima
CytoScan Optima Kit Arrays and reagent sufficient for 24 reactions 902533
CytoScan Optima Training Kit Arrays and reagent sufficient for 24 reactions plus training materials 902534
CytoScan HT-CMA
CytoScan HT-CMA 96F Assay Kit Arrays and reagent sufficient for 96 reactions 906025
CytoScan HT-CMA 96F Assay Training Kit Arrays and reagent sufficient for 96 reactions plus training materials 906027
CytoScan XON
CytoScan XON Assay Kit Arrays and reagent sufficient for 24 reactions 931311
CytoScan XON Assay Training Kit Arrays and reagent sufficient for 24 reactions plus training materials 931312

11
Ordering information continued
Product Description Cat. No
OncoScan
OncoScan CNV Plus Assay Arrays and reagent sufficient for 24 reactions 902293
OncoScan CNV Plus Training Kit Arrays and reagent sufficient for 18 reactions plus training materials 902305
OncoScan CNV Assay Arrays and reagent sufficient for 24 reactions 902695
OncoScan CNV Training Kit Arrays and reagent sufficient for 18 reactions plus training materials 902693
Analysis software
Chromosome Analysis Suite (ChAS) Available as a free download from thermofisher.com/chas NA
24 tokens 00.1001
CytoScan Automated Interpretation and
96 tokens 00.1003
Reporting (AIR) Tokens
384 tokens 00.1004
Support products
Reproductive Health Research Analysis Available as a free download from thermofisher.com/chas NA
Suite (RHAS)
GeneChip System 3000 Includes: 00-0218
GeneChip Scanner 3000 with AutoLoader
GeneChip Fluidics Station 450
GeneChip Hybridization Oven 645i
Workstation with GeneChip Data Collection Software
GeneChip Fluidics Station 450 Single station available for purchase separately from 00-0079
the GeneChip System 3000
GeneChip Hybridization Oven 645i Single unit available for purchase separately from 00-0331
the GeneChip System 3000
GeneTitan MC Fast Scan Instrument Automated array-processing instrument required to hybridize, 00-0373
wash, stain, and scan arrays
NIMBUS Target Preparation Instrument Robotics workstation and laptop 00-401
NIMBUS CytoScan Training Kit
™ ™
Sample preparation reagents to be used with robotics workstation 902169

References
1. Levy B, Wapner R. Prenatal diagnosis by chromosomal microarray analysis. Fertil Steril. 2018 Feb;109(2):201-212.
doi: 10.1016/j.fertnstert.2018.01.005. PMID: 29447663; PMCID: PMC5856154.
2. Manning M, Hudgins L; American College of Medical Genetics and Genomics (ACMG) Professional Practice and
Guidelines Committee. Addendum: Array-based technology and recommendations for utilization in medical genetics
practice for detection of chromosomal abnormalities. Genet Med. 2020 Dec;22(12):2126. doi: 10.1038/s41436-
020-0848-8. Epub 2020 Jun 8. Erratum for: Genet Med. 2010 Nov;12(11):742-5. PMID: 32514088.
3. Shao L, Akkari Y, Cooley LD, Miller DT, Seifert BA, Wolff DJ, Mikhail FM; ACMG Laboratory Quality Assurance
Committee. Chromosomal microarray analysis, including constitutional and neoplastic disease applications, 2021
revision: a technical standard of the American College of Medical Genetics and Genomics (ACMG). Genet Med. 2021
Oct;23(10):1818-1829. doi: 10.1038/s41436-021-01214-w. Epub 2021 Jun 15. PMID: 34131312.

Learn more at thermofisher.com/reproductivehealth

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