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    Pharma Bonus

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    afaan18m3742

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    Pharma Bonus

    Uploaded by

    afaan18m3742
    2 views14 pages

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    Pharma bonus

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    Copyright:

    © All Rights Reserved
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    Download as pdf or txt
    2 views14 pages

    Pharma Bonus

    Uploaded by

    afaan18m3742

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 14

    GENERAL PHARMACOLOGY

    BONUS-BTR
    ANS
    Parasympathetic:
    DUMBELS

    PUPIL:
    Cholinergic:
    Anticholinergic:
    Sympathetic:
    Anti-sympathetic:

    OP, Early mushroom poisoning :

    Late mushroom:
    Datura/Jimson weed poisoning:

    M1
    Children:
    M2
    M3
    Cholinergic drugs Anti-cholinergic drugs

    Cevimeline

    Darfenacine

    Pirenzepine
    Botulinum toxin
    Vesamicol
    Varenicline Hemicholinum
    Alpha / Beta Agonists and Antagonists
    Receptors Indirect agonists
    a1 BV: PUPIL: UB: Amphetamine
    Agonist- Cocaine
    Antagonist- Ephedrine

    a2 ALPHA BLOCKERS
    Agonist- S/e:
    Antagonist- Non-selective
    Phenoxybenzamine
    b1 HR:
    Phentolamine
    Agonist-
    Antagonist-
    Selective alpha-1
    b2 BV: Bowel-bladder-uterus: Bronchus: Prazosin, Terazosin, Doxazosin
    Tremor: Sugar:
    Agonist-
    Antagonist- Tamsulosin

    b3
    Agonist-
    Alpha / Beta Agonists
    DOPAMINE
    Norepinephrine SBP
    <2 ug/kg/min
    Epinephrine DBP
    2-10
    Isoproterenol HR
    >10

    Dopexamine
    Fenoldopam
    DOC
    Septic shock, Neurogenic shock
    Cardiogenic shock-refractory

    Cardiogenic shock

    Cardiogenic shock + oliguria

    CPR, Anaphylactic shock

    Postural hypotension

    Spinal induced hypotension


    Effect on BP and HR
    Beta Blockers
    BETA BLOCKERS USES:
    B1 selective: CVS
    Atenolol Glaucoma
    Betaxolol Performance anxiety
    Bisoprolol Thyroid storm
    Esmolol Akathisia
    Metoprolol Migraine prophylaxis
    Nebivolol: Essential tremors
    Celiprolol:
    Acebutolol:

    Non-selective: CI:
    Nadolol: Bradycardia
    Propranolol: AV block
    Timolol: Acute CHF
    Pindolol: Asthma
    PVD
    Alpha + beta blockers: Carvedilol, Labetalol DM
    Prinzmetal angina
    Tillisolol: DOC for toxicity:
    Sotalol:
    Peptide:
    Autocoids Amine:
    Lipid:

    Receptor Receptor
    H1
    Antagonist: 5HT 1A
    H2 Agonist:
    Antagonist:
    5HT 1B/D
    H3
    Inverse agonist: Pitolisant/Tiprolisant Agonist:
    H4 5HT 2A/2C
    Antagonist:
    Agonist:
    5HT 3
    Antagonist:

    5HT4
    Agonist:
    PG and NSAIDs

    PGE1

    Latanoprost Alprostadil Dinoprostone Iloprost


    Epoprostenol
    Selexipag
    Carboprost Misoprostol
    Dinoprost

    Lubiprostone
    General pharmacology lists
    High first pass metabolism Trandermal patch Volume of distribution

    Lignocaine Nicotine patch Plasma protein binding:


    Fentanyl Hyoscine Lipid solubility:
    Natural steroids-GC, MC, E, PR Diphenhydramine
    Nitrates Hemodialysis:
    Propranolol Clonidine Barbiturate
    Morphine Seligiline Lithium
    Verapamil Rivastigmine Alcohol
    Salbutamol Ritogitine Saliylates
    Nitrates HRT Theophylline
    Imipramine
    Max Vd:
    Forced alkaline diuresis Forced acidic diuresis
    General pharmacology lists
    Acetylation PRODRUGS: PLAMA ESTERASE:
    Carbimazole
    Clopidogrel Pseudocholiesterase:
    Prednisone
    Prasugrel Hoffman:
    Levodopa
    Gynecomastia ACE- except:
    Sulfasalazine
    Pharmacogenetic testing:
    Mycophenolate
    Acyclovir/ Gancyclovir
    TPMT:
    VKORC1 / CYP2C9:
    DHPD:

    Counterfeit drugs: Essential drugs :


    Ototoxins:
    SPURIOUS = FALSIFIED Cost effective
    Prevalent diseases
    MISBRANDED Available easily
    No combination
    ADULTERED
    Miscellaneous
    Anti-obesity Approved drugs:
    Phentermine + topiramate
    Bupropion + zonisamide
    Liraglutide
    Semaglutide
    Tirzepatide
    Orlistat, Cetilistat

    SICKLE CELL ANEMIA:


    Glutamic acid Oprelevkin
    Hydroxyurea Romiplostim
    Voxelotor Eltrombopag
    Crizanlizumab
    Schedules and categories

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