i MICROBIOLOGY CONCEPTS Syllabus I. General Description A. Course Director: Thomas F. Lint, Ph.D.; Office: 306 Professional Building I; ext.

2-3513. [email protected] Associate Course Director: Nell Lurain, Ph.D.; Office: 862 Jelke; ext. 2-8734 B. C. Course Faculty: L.J. Goodman, D.D. Huang, N. Lurain, T.F. Lint, L.A. Proia, K. Singh. Course Objectives - Upon completion of the course, the student should be able to: 1) describe the spread and the consequences of infection within a host and within a population for each bacterium, virus, fungus and parasite identified as important by the faculty; describe the basic biological characteristics of these organisms and the relationship between these characteristics and their ability to cause disease; describe the laboratory methods for identifying these organisms; be able to identify and differentiate between diverse organisms causing the same disease syndrome.

2) 3) 4) D.

Required Text: Murray, P.R. et al. Medical Microbiology, 6th ed., 2009. A good understandable text. Strengths are the tables, diagrams and figures which help integrate concepts with pertinent facts from both a basic science and clinical perspective. Text is especially useful for parasitology and virology sections. Best collection of color images of all the Microbiology texts. Recommended Text: Gilligan, P.H. et al. Cases in Medical Microbiology and Infectious Diseases, 3rd edition, 2002. A text containing case studies presented as "unknowns" accompanied by questions testing knowledge in pathogenesis, clinical characteristics, laboratory diagnosis, epidemiology and therapy in some cases. Students should read the cases assigned to each lecture before coming to class and be prepared to discuss the information in the case and answers to the case questions.

II.

Mode of Instruction A. Lectures will be given at the times listed in the lecture schedule. For each lecture, the

ii Lecture Notes contains objectives for the lecture, key words, an outline of lecture material, and some supplementary material. B. Winter Quarter: Laboratory sessions are scheduled, to be held (after an initial introduction in the Room 539 lecture hall) in the MDL. A separate laboratory manual will be issued to you. The first laboratory session is a techniques laboratory. The other sessions with a bacterial infection case presentation and unknowns will follow. The results from your lab unknowns will account for 8% of your final grade. Some charts are also included in the manual for your use in learning the material or for review. Three sessions are planned for self study of cases which allow for the identification and differentiation of diverse organisms causing the same disease. These are presented as self-directed learning sessions, with unknowns to be identified over a three-week period and reported from data presented on computers in the MDL and the METC. Work sheets for the identification of these unknown pathogens are also included in your lab manual, which contains almost all the data needed to complete this part of the course. Winter Quarter: There will be a small group exercise in problem solving in Microbiology. Attendance and participation in these sessions will count for 2% of the final grade.

C.

D.

III.

Methods of Evaluation

Quiz and exam questions will be based on the learning objectives which precede each lecture topic. Questions will be taken from the syllabus, lecture, texts, or material covered during the two case study exercises. They will test basic, applied and conceptual knowledge of the material presented. There will be a short quiz after the first three weeks of class (fall quarter) and two weeks after the beginning of class (winter quarter) with questions similar to those you will see on the midterm and final. These quizzes are designed to help you evaluate how effectively you are studying. Each quiz will account for 5% of your final grade. The midterm examination will cover the Bacteriology portion of the course. This will account for ~35% of your final grade. The final examination will be divided into two portions: 1) The unit exam part will cover Mycology, Virology and Parasitology and will account for ~20% of your final grade; 2) The comprehensive portion of the final exam will cover the entire course and will be based on case studies similar to the ones presented in lectures, the laboratory exercises and interactive diagnoses sessions. This comprehensive portion of the final exam will account for ~25% of your final grade. Breakdown of grading: 10% quizzes (2), 1 in Fall quarter (5% of grade), 1 in Winter quarter (5% of grade) 8% attendance at demonstration laboratory sessions (winter), and identification of

iii unknowns in the lab, including completion of identification of unknowns in computerbased self-study sessions. 2% interactive small group infectious disease problem based sessions (winter). Attendance required to receive points. ~35% midterm (bacteriology, mycology) end of fall quarter. Final exam 2 parts (end of winter quarter). ~20% unit final (Part 1: virology, parasitology) ~25% comprehensive final (Part 2: case scenarios, covering the entire course). A flat averaged grade of 70% will be considered passing or one and one-half standard deviations below the mean (whichever is lower). The upper 15% of the class or anyone achieving a score > 90% will receive honors. Attendance Policy: The small group sessions in the winter are planned as co-operative, team-based learning sessions. Since there is no way to make-up a missed session, and attendance is the criterion for obtaining the points for these sessions, no points will given to students who miss these sessions, for any reason. A proficiency examination will be available to anyone whom the Course Director feels has the necessary background. This examination will be given the first week of the course. A flat 70% will result in a passing grade which will be reported to the Registrar's Office. Anyone wishing to take this examination should consult Dr. Lint. Any student receiving a failing grade on any examination has the responsibility of discussing this grade with the Course Director. The necessary remedial work will be decided jointly by the student and the Course Director, with input from COSEP or the Deans Office, if necessary. A comprehensive make-up examination will be available, during the summer, for any student receiving a failing grade in the course.

For information or to request an accommodation, please contact your college representative listed below. Please do not make requests for accommodation to individual faculty members, lecturers or course directors. 1RUSH UNIVERSITY POLICIES AND PROCEDURES

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FOR STUDENTS WITH DISABILITIES In keeping with its goal to promote diversity among its student population, Rush University is committed to attracting and educating students who will help to make the population of health care professionals representative of the national population, including students with disabilities. In addition, Rush University wishes to insure that access to its facilities, programs and services are available to students with disabilities. The University provides reasonable accommodations to all students on a nondiscriminatory basis consistent with legal requirements as outlined in the Americans with Disabilities Act (ADA) of 1990 and the Rehabilitation Act of 1973. A reasonable accommodation is a modification or adjustment to an instructional activity, facility, program or service that enables a qualified student with a disability to have an equal opportunity to participate in all Rush University student activities. To be eligible for accommodations, a student must have a documented disability as defined by the ADA and Section 504 of the Rehabilitation Act of 1973. Both the ADA and Section 504 define disability as (a) a physical or mental impairment that substantially limits one or more major life activities of such individual; (b) a record of such impairment; or (c) being regarded as having such a condition. Rush University Student Disability Assessment Team (RUSDAT) Rush Medical College Robert M. Leven, Ph.D. (312) 942-6779 [email protected] Further information can be found at: http://www.rushu.rush.edu/catalog/aboutrush/disabilityrights.html