Full Download Clinical Cases in Internal Medicine 1st Edition Samy Azer PDF
Full Download Clinical Cases in Internal Medicine 1st Edition Samy Azer PDF
Full Download Clinical Cases in Internal Medicine 1st Edition Samy Azer PDF
com
OR CLICK BUTTON
DOWLOAD EBOOK
https://ebookmass.com/product/hupperts-notes-pathophysiology-and-
clinical-pearls-for-internal-medicine-laura-huppert/
https://ebookmass.com/product/clinical-cases-in-paramedicine-1st-
edition-sam-willis/
https://ebookmass.com/product/internal-medicine-5th-edition-
eugene-toy/
https://ebookmass.com/product/diagnosis-and-treatment-in-
internal-medicine-oxford-university-press-1st-edition-patrick-
davey/
Clinical Cases in Uveitis Harpal Sandhu
https://ebookmass.com/product/clinical-cases-in-uveitis-harpal-
sandhu/
https://ebookmass.com/product/essential-learning-for-the-
internal-medicine-clerkship-1st-edition-conrad-fischer/
https://ebookmass.com/product/a-medication-guide-to-internal-
medicine-tests-and-procedures-1st-edition-gregory-j-hughes/
https://ebookmass.com/product/harrisons-principles-of-internal-
medicine-21st-edition-loscalzo/
https://ebookmass.com/product/case-files-internal-medicine-6th-
edition-eugene-c-toy/
Clinical Cases in
INTERNAL MEDICINE
This page intentionally left blank
Clinical Cases in
INTERNAL MEDICINE
SAMY AZER
MB, BCh, MSc Medicine, PhD (Syd), MEd (NSW), FACG, MPH (NSW)
Professor of Medical Education
College of Medicine, King Saud University, Saudi Arabia
Formerly Professor of Medical Education, Universiti Teknologi
MARA, Malaysia
Visiting Professor of Medical Education, University of Toyama, Japan
Formerly Senior Lecturer of Medical Education, Faculty of
Medicine, Dentistry and Health Sciences, the University of
Melbourne and School of Medicine, the University of Sydney,
Australia
Elsevier Australia. ACN 001 002 357
(a division of Reed International Books Australia Pty Ltd)
Tower 1, 475 Victoria Avenue, Chatswood, NSW 2067
All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means,
electronic or mechanical, including photocopying, recording, or any information storage and retrieval system,
without permission in writing from the publisher. Details on how to seek permission, further information about
the Publisher’s permissions policies and our arrangements with organizations such as the Copyright Clearance
Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions.
This book and the individual contributions contained in it are protected under copyright by the Publisher (other
than as may be noted herein).
ISBN: 978-0-7020-8049-4
Notice
Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using
any information, methods, compounds or experiments described herein. Because of rapid advances in the
medical sciences, in particular, independent verification of diagnoses and drug dosages should be made. To
the fullest extent of the law, no responsibility is assumed by Elsevier, authors, editors or contributors for any
injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from
any use or operation of any methods, products, instructions, or ideas contained in the material herein.
To
My family for their love and support, and
To
My grandchildren – Jemimah, Elizabeth, Christopher, Asher
FOREWORD
To face the challenges of modern health care, future physicians must master not only an
extensive knowledge base but also the analytical and integrative thinking skills needed
to provide safe, comprehensive patient care in the context of clinical complexity.
While many textbooks present the content of this comprehensive knowledge base, Clinical
Cases in Internal Medicine additionally guides learners on the process to apply knowledge and
scientifically understand the various concerns (expressed in lay terms) that patients entrust their
physicians to address. In this textbook, the concise and memorable case discussions highlight
the differential diagnoses that must be systematically considered and review the mechanisms
that explain the patient’s signs and symptoms and the basis for why certain treatments work.
The tables and figures are truly high-yield and helpful in practice. The questions, throughout
the chapter, are framed very thoughtfully around queries that arise in clinical decision-making,
in education of patients and families and in preparation for standardised examinations.
This textbook is ideal for students – in both problem-based learning (PBL) and tra-
ditional curricula – hoping to deepen their learning through case-based and interactive
learning approaches.
Professor Samy Azer is an internationally renowned medical educator, who cur-
rently serves as Professor of Medical Education at the College of Medicine, King Saud
University in Saudi Arabia. He has formerly served as Professor of Medical Education
at the Universiti Teknologi MARA in Malaysia;Visiting Professor of Medical Education
at the University of Toyama in Japan; and Senior Lecturer of Medical Education at the
Faculty of Medicine, Dentistry and Health Sciences at the University of Melbourne and
at the School of Medicine at the University of Sydney in Australia.
Through his commitment to innovations that optimise clinical learning and teaching and
through publications and other connections that make these innovations graspable and acces-
sible, Professor Azer has been an inspiration to the global community of medical educators and
students alike. I join Professor Azer in his hope that educator colleagues, students and future
patients will all benefit from the journey of learning through the cases presented in this text.
vi
FOREWORD
Medical curricula have changed worldwide to reflect the changing roles of health sys-
tems and the challenges faced by graduating doctors. The advances in technology and
the overwhelming increase in scientific and medical publications add to these challenges
and the need to prepare our doctors at the best international standards and reassuring
their continuing professional development.
This book addresses these needs as a learning resource to be used by students and
other recommended and prescribed resources and enables them to study 50 clinical
cases and apply knowledge to clinically relevant topics in their undergraduate curricu-
lum.
Practising clinicians tend to use ‘schema’ in their reasoning to arrive at a diagnosis
based on pattern recognition and previous experience. However, undergraduate students
did not have sufficient experience and seeing patients in the wards may not be available
for their clinical training. Furthermore, most hospitals are moving to minimally invasive
techniques and one-day care and minimising the length of hospital stay with the new
developments in diagnosis and patient management. These days there are changes in
hospital admission because of the COVID-19 pandemic. These changes have affected
bedside teaching worldwide and the need for alternative teaching/learning methods to
address the students’ learning needs and enhance their clinical skills.
Professor Azer, the chair of the curriculum development and research unit at King
Saud University, has written this book with these challenges in mind. The book reflects
his international expertise in the field and addresses this area of need. International experts
have reviewed the book and provide the core clinical cases taught in internal medicine.
Students may use this book together with their clinical sessions and seeing patients in the
wards presenting with illnesses described. Students may critically compare between clinical
findings they identified in the patient and what was discussed in the clinical cases in the
book. They may also answer questions and revise the MCQs at the end of each case.
Together with reading recommended resources and reviewing their lectures, such
preparation will help in their clinical learning.
I am proud that Professor Azer is an academic at King Saud University for his
achievement and contribution to the medical profession at the global, local and interna-
tional levels. I want to congratulate the author on this achievement, and it is my pleasure
to commend this book as an additional resource to medical students and clinical teach-
ers. This book will be a valuable resource to medical libraries, students and clinicians,
medical educators and curriculum designers.
vii
PREFACE
Clinical Cases in Internal Medicine is not a textbook covering the whole undergraduate
curriculum in internal medicine. Although reading texts and daily engagement with
simulated patients and actual patients is vital to enhance your competency in medicine,
students also need to complement their learning through case-based learning.
This book is written for students as a learning resource to use with other standard
textbooks and resources recommended in this discipline. It comprises 50 cases in inter-
nal medicine covering different body systems and focuses on common diseases that all
medical students should know.
Learning through cases helps students to master several skills and deepen their under-
standing by applying theoretical knowledge. It brings factual knowledge to what they
face in practice. Case scenarios also stimulate students' thinking to interpret the history
findings and clinical findings, generate hypotheses, construct a differential diagnosis,
relates basic knowledge from physiology and pathology to the clinical picture, interprets
laboratory findings and design a management plan.
Clinical Cases in Internal Medicine can be used on an individual basis or in small-group
tutorials with or without a tutor. After reading the case scenarios, students could start answer-
ing each question that follows the scenario—one student in the group summarise critical
points raised in the group discussion- act as the group scribe, and guiding the group discus-
sion. During this process, students may identify gaps in their knowledge or issues they do not
know. Also, questions raised could stimulate further thinking, search for answers/evidence and
turning the discussion into a meaningful session. Through active learning, and self-regulated
learning and examining other resources, students could deepen their understanding of the
case, explore relationships, and turn their learning into engaging and stimulating behaviour.
After completing the case discussion, a section titled ‘back to basics’ has been included
in each case. This section aims at linking knowledge from physiology, pathology, patho-
genesis, microbiology and pharmacology with the case clinical discussion. Students may
try answering the short-answer questions in this section, then compare their responses
with the answers provided. Each case discussion ends with 5-6 multiple-choice questions
that students could try on their own, then check at the end their performance against
model answers and justification given. At last, the case discussion ends with ‘a take-home
message’. and ‘further readings’ from the literature. These resources are recommended
for students to dig deeper and read more about current knowledge related to the case.
I wish success to all my current students and graduates at different universities where I
was honoured to teach and other universities worldwide enforcing active learning practices.
Samy Azer
Melbourne
2021
viii
ACKNOWLEDGEMENTS
ix
ABBREVIATIONS
5-HT 5-hydroxytryptamine
ACE Angiotensin-converting enzyme
AChR Anti-acetylcholine receptor
ACTH Adrenocorticotrophic hormone
ADH Antidiuretic hormone
AFB Acid-fast bacillus
AHR Airway hyper-reactivity
AIDS Acquired immunodeficiency syndrome
ALT Alanine aminotransferase
ANA Antinuclear antibody
Anti-La (or SS-B) These occur in 10%–20% of patients with systemic lupus
autoantibodies erythematosus and 50% of patients with primary or secondary
Sjögren syndrome; maternal anti-La (SS-B) autoantibodies
are associated with neonatal lupus syndromes, particularly
congenital heart block
Anti-Ro (anti-SS-A) These are anti–Sjögren-syndrome-related antigen A autoanti-
autoantibodies bodies; also called anti-Ro
Anti-U1-RNP It is a serological marker for MCTD; It can be also detected
in patients with systemic sclerosis or SLE
APACHE-II Acute Physiology and Chronic Health Evaluation II
APC Adenomatous polyposis coli
AST Aspartate aminotransferase
ATP Adenosine triphosphate
AV node Atrioventricular node
B. burgdorferi Borrelia burgdorferi
BCG Bacillus Calmette–Guérin vaccine
BCR-ABL It is a mutation formed by the combination of two genes,
known as BCR and ABL; the mutated chromosome 22 is
called the Philadelphia chromosome (referring to the city
where researchers first discovered Ph chromosome)
BG Blood glucose
BMD Bone mass density
BMI Body mass index
BNP Brain natriuretic peptide
BPPV Benign paroxysmal positional vertigo
C, T, L, S nerve roots C, cervical; T, thoracic; L, lumbar; S, sacral nerve roots
C. jejuni Campylobacter jejuni
x
Abbreviations xi
S3 heart sound The third heart sound, is an extra heart sound, also known as
the ventricular gallop; it occurs just after S2
S4 heart sound The fourth heart sound, is an extra heart sound, also known
as the atrial gallop; it occurs just before S1 when the atria
contract to force blood into the left ventricle; it can be heard
in acute myocardial infarction, cardiomyopathy, aortic stenosis
and left bundle branch block
SA node Sinoatrial node
SAH Subarachnoid haemorrhage
SaO2 Oxygen saturation
SARS-CoV Severe acute respiratory syndrome
SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2
SC Subcutaneous
SIADH Syndrome of inappropriate antidiuretic hormone secretion
SLE Systemic lupus erythematosus
SPEP Serum protein electrophoresis
SSTR2 Somatostatin receptor type 2
ST segment In ECG, the ST segment represents the interval between
ventricular depolarisation and repolarisation
T wave In ECG, the T wave represents the repolarisation of the
ventricles
T3 Tri-iodothyronine
T4 Thyroxine
TB Tuberculosis
TGF-ß Transforming growth factor-beta
Th-1 or Th1 cell T-helper cell-type 1
TH1 T-helper type 1 cells are a lineage of CD41
TH2 T-helper type 2 cells are a distinct lineage of CD41
TIA Transient ischemic attack
TIBC Total iron-binding capacity
TNF-a Tumour necrosis factor-alpha
TNM staging Staging of cancer: T, tumour size; N, spread to lymph nodes;
M, metastasis
TP53 gene It is located on the short arm of chromosome 17 (17p13.1)
and its mutation plays a role in cancer development
TPMT Thiopurine methyltransferase
TRAb TSH receptor IgG antibody, also known as thyrotrophin
receptor antibody
TRAs Thrombopoietin receptor agonists
TSH Thyroid-stimulating hormone
tTG Tissue transglutaminase
Abbreviations xvii
Forewords vi-vii
Preface viii
Acknowledgements ix
Abbreviations x
xviii
Contents xix
“If books of this sort can be used by others than experts, this one
has the advantage of simplicity.”
+ Booklist 16:297 Je ’20
“The appendices with their diagrams are not the least valuable
parts of the work. The mentimeter tests form its more especially
unique feature.”
“The chief value of the book lies in its contribution to the general
education of the public.”
“The nine stories in this volume deal with the affairs of the firm of
Tutt & Tutt (the members are not related), the senior partner of
which is always addressed deferentially by his colleague as Mr Tutt.
It is Mr Tutt who tries the cases, Tutt who does the work of preparing
them; and to the unfriendly eye their activities might seem those of
shysters if they were not devoted, as a rule, to the worthy object of
protecting the poor and friendless against the stupidities and
brutalities of the law and some of those who practice it. The hero of
the book is Mr Tutt, who in the first story has a frame like Lincoln’s,
and by the end of the book has progressed so far that his face looks
like Lincoln’s. The villain, it must be confessed, is the law itself.”—N
Y Times
Booklist 16:315 Je ’20
Cleveland p72 Ag ’20 50w
+ Ind 103:323 S 11 ’20 40w
“The best of the nine are very good, and all of them are
ornamented by entertaining comments on the philosophy of the law
and justice.”
“The novel is a long and fairly interesting one, but it gives the
impression that the author has gathered a great deal of commonplace
material before she begins and pours it into the pages through a
hopper. Readable as the book is, it is singularly lacking in literary
grace.”
“The story is intense and written in the same brilliant style that
characterized Miss Tremayne’s previous story, ‘The auction mart.’”
“The interest of the book lies in the slow revelation of the character
of Echo. It is a tribute to the author that the reader finds his
impatience with Echo gradually changing to sympathy; it is as if he
encountered her in real life and found that he liked her better as he
knew her more intimately.”
“‘You are the eddy—they are the tide’, says Mrs Wickham to
Napoleon over the body of her dead son. The tide of humanity
sweeps onward, and the Napoleonic selfishnesses and individualisms
that run counter to it are no more than eddies swirling back against
the current, soon to be straightened out again by the irresistible
onrush. Geoffrey Wickham is the apostle of humanity, whose aim it
is to make Napoleon see the unreasonableness of his attitude. His
plan is to kidnap Napoleon from Boulogne—it is the year of the
threatened invasion of England—to take him out to sea, and there, in
solitude, to persuade him into reason. The plot of the play, which is
full of dramatic situations, is the story of his failure and death.”—Ath
“Mr Trench uses prose as his medium except in the critical scene
between Wickham and Napoleon, where he rises to a fine and rather
Browning-like blank verse.”
“Mr Trench’s play is worth all his poems twice over. It is one of the
few real fruits of the war.” Mark Van Doren
“Surely this play is not merely to be read, but to be seen. But every
character is clear in outline, awaiting embodiment, demanding
presentment. Its characters are never mere puppets ... not even
Napoleon who must by now be more disgustedly weary of his earthly
immortality than any denizen of the underworld. He, at any rate
should return thanks to Mr Trench for this just, urbane and pitiless
rehabilitation.”
“It was a happy chance that caused the authorized life of the
second Earl Grey to be left half finished sixty years ago, and that
induced the late Lord Grey to assign the task to Mr George
Trevelyan. The Lord Grey who passed the reform bill of 1832 has
always been an enigma to later generations. His political career was
like a drama in which the hero holds the stage in the first act and has
a brief and effective scene in the second act, but then is seen no more
till the fifth act. Entering Parliament in 1787, when he was twenty-
three, he attached himself to Fox, and made himself notorious by
founding the Society of the friends of the people and by moving
annual resolutions in favour of parliamentary reform. He succeeded
to his father’s peerage in November, 1807, and felt that his career
was ended. Three-and-twenty years had passed when all at once
England discovered that the retired statesman was, like Cincinnatus,
the one man who could extricate her from a dangerous situation.
Lord Grey tore himself from his country pleasures, took command of
a mixed and quarrelsome team of Whigs, radicals, and Canningites,
and set himself to achieve parliamentary reform with such skill and
determination as few ministers have ever displayed.”—Spec
“It is a fascinating story, excellently told, and even the reader who
knows little of English political history will find it interesting on
account of the light and hope that it sheds on modern conditions.” A.
G. Porritt
“Within its own limits and for its own public the work could not be
better done, and will confirm and establish its author’s reputation as
a biographer and historian. It is brilliantly written, and the right
reader, especially the lover of English political history, will not
willingly lay it down till he has drunk his cup of pleasure to the last
drop. It is full, too, of interesting judgments on matters which only
incidentally come within its scope.”
+ The Times [London] Lit Sup p193 Mr
25 ’20 3200w
The writer was impressed with the need of a short history of Italy
while giving a series of lantern lectures on Italian history to London
school children in 1902. The present volume, which the author
modestly calls a “summary” is the result “of a deep and growing love
for the subject, of many wanderings in the bypaths of Italy, and of an
inherited affection for her present population.” (Preface) She
disclaims having made any original research, studied the archives, or
made new discoveries. “But I have endeavoured, by using the work
already done on each period by Italian, British, French, and German
scholars, and by illuminating it with the sayings of contemporary
writers, to present a narrative as near the truth as it was possible for
me to make it.” (Preface) Partial contents: Italy in the century
preceding the barbarian invasions (284–395); The barbarian
invasions (395–476); The beginnings of the middle ages (800–
1002); The rise of the cities, and their conflict with Frederick
Barbarossa (1100–1183); Rome and the papacy during the fourteenth
century (1305–1389); Italy in the sixteenth century; Napoleon’s first
conquest of Italy (1792–1799); The years of revolution (1846–1849);
The completion of Italian unity (1860–1870); Epilogue;
Bibliography; Index. There are twenty-four illustrations and six
maps.
“Mrs Trevelyan has wrestled with the difficulties of her subject
with marked success. She has a thorough grasp of essentials and a
due sense of proportion which have enabled her to produce an
admirably balanced, well-arranged book, while she writes in a way
that is sure to make it widely read.” L. C.-M.
“The chapters are well arranged and in all but the spirit of the
presentation of the material, satisfactory.”
“As is the case with all English histories of Italy, the least
satisfactory part of the book is the ‘Epilogue,’ which treats of the fifty
years since 1870.” W. M.
“He is an industrious disciple and sets his matter out lucidly and
uncritically. He will give the intelligent reader some appreciation
both of the value of psychoanalytic work and (though unconsciously)
of some of the extravagances of psychoanalytic enthusiasts.”
“The fact that most of the material is of quite recent creation gives
the volume an interest not shared by older anthologies of the same
character.”
This is a plea that we substitute for our old “dry as dust” method of
teaching history “an elementary study of nationality.” In a high
school course such as this book proposes, “each nation is carefully
considered by itself, that pupils may gain a definite impression of its
individual characteristics. First it is viewed as it appears today; then
its development is briefly traced. After this historic background has
been sketched in, an attempt is made to evaluate the peculiar gifts of
the country and its people to the sum of modern civilization.”
(Preface) This is a pioneer book, for the use of teachers, and, as such,
the main part of it is devoted to helpfully suggestive material,
outlines, and comments upon the following nations: France,
England, Germany, Russia, Italy, Austro-Hungary, Turkey and the
Balkan states, China, Japan, and the Philippine Islands (“a nation in
the making”). The book includes a complete bibliographical list, and
a connected outline of all the chapters. The chapters on China and
Japan were contributed by Dr K. S. Latourette. Dr Tuell is the head
of the department of history, Somerville high school, Massachusetts.
[2]
TUOHY, FERDINAND. Secret corps. *$2
Seltzer 940.485
(Eng ed 20–11008)
Reviewed by E. L. Pearson
“In style and method the latter half of the book is somewhat like
those editorial summaries of current events contained in some of the
best modern journals. It is concise, considered, rather neutral, but
useful for exactly the purpose for which it was designed. The book’s
value lies not so much in the backward glimpses of the past from the
present point of view as in the light thrown forward on the war and
upon our present state by the course of events since 1879.”