Intraepidermal Autoimmune Bullous Dermatoses: Principles of Diagnosis
Intraepidermal Autoimmune Bullous Dermatoses: Principles of Diagnosis
Intraepidermal Autoimmune Bullous Dermatoses: Principles of Diagnosis
Nicolae Testemianu
Chisinau, Republic of Moldova.
Intraepidermal
autoimmune bullous
dermatoses:
principles of
diagnosis.
Husein Abu Eid
medicine faculty nr.2 - gr.1041
Dr. Vladislav GOGU, Chairman
MD, PhD, Associate Professor
Department of Dermatovenereology
Background
Intraepidermal autoimmune bullous dermatoses
(pemphigus family) include a group of skin diseases which
are characterized by the presence of bullae or vesicles
and are caused by autoantibodies that are directed
against desmosomal structural proteins. [1]
The majority intraepidemal autoimmune bullous
dermatoses are associated with various severe damages
of organs and systems which can lead to serious
complications and even death of patients. [2]
Clinical common features between the majority types of
pemphigus, not always convincing results of Nikolsky`s
sign, limited access to special laboratory examinations
which allow to confirm the preliminary diagnosis.
1%6%
13%
2%
4%
74%
Pemphigus vulgaris Pemphigus vegetans
Pemphigus foliaceus Pemphigus erythematosus
Pemphigus herpetiformis Paraneoplasic pemphigus
The sensitivity of
clinical findings 52,8 50,8 41,6
(%)
The sensitivity of
histological 78 52,5 50
findings (%)
Baican Corina, Baican A, Rogojan L, Ciuce D, Samasca G, Macovei V, Perta A, Maier N, Sitaru C.
The sensitivity of clinical, histologic and immunologic findings for the diagnosis of autoimmune
bullous disease. Dermatovenerologie 2011;56:11-19
The predictive value of Nikolsky`s sign in differential
diagnostics of intraepidermal autoimmune bullous
dermatoses.
The sensitivity of
clinical findings 52,8 50,8 41,6
(%)
The sensitivity of
histological 78 52,5 50
findings (%)
Baican Corina, Baican A, Rogojan L, Ciuce D, Samasca G, Macovei V, Perta A, Maier N, Sitaru C.
The sensitivity of clinical, histologic and immunologic findings for the diagnosis of autoimmune
bullous disease. Dermatovenerologie 2011;56:11-19
The intraepidermal immunobullous diseases:
immunopathology and immunogenetics.
Disease1 Direct IMF Isotype Target antigens Epitopes Location
Dermatitis - - - - 72.7%
herpetiformis
Baican Corina, Baican A, Rogojan L, Ciuce D, Samasca G, Macovei V, Perta A, Maier N, Sitaru C. The
sensitivity of clinical, histologic and immunologic findings for the diagnosis of autoimmune bullous
disease. Dermatovenerologie 2011;56:11-19.
Diagnostic criteria for pemphigus vulgaris
(Yehuda Shoenfeld et al 2008)