#31: NUTRITION SUPPORT IN SEPSIS AND

MORBID OBESITY

BROOKE BENNINGER, LAUREN LUCAS, STEPHANIE LEE, JOSE ALVAREZ

 INTRODUCTION TO PATIENT
 Personal Data
 Mr. Chris McKinley, 37 y.o.
 Came in weighing 325# and is 5’10”
 Office manager for real estate office
 Caucasian; single
 Lives with a roommate
 Has weighed over 250 pounds since the age of 15 with steady weight gain
 No tobacco use; socially drinks 2-3 beers/week
 INTRODUCTION TO PATIENT

 Current Admission
 Started experiencing flu-like symptoms over previous 48 hours
 Acute SOB; admitted to MICU with probable sepsis

 Social, Psychological, Economic History

 Associate’s degree
 No children; lives with roommate
 Has attempted to lose weight; lost 75# at one point; regained over 2-yr period
 No tobacco use; socially drinks 2-3 beers; no alcohol since surgery
 INTRODUCTION TO PATIENT

 Medical History
 Type 2 DM, hypertension, hyperlipidemia, osteoarthritis over previous 10 years
 Currently on Lovastatin 60 mg/day (used to treat high cholesterol, high triglycerides)
 Roux-en-Y gastric bypass surgery 4 months ago; total knee replacement 3 years previous

 Family History
 Father: Type 2 DM, CAD, Htn, COPD
 Mother: Type 2 DM, CAD, osteoporosis
 WHAT IS SEPSIS? MORBID OBESITY?

 Sepsis  Morbid Obesity

 Life-threatening condition that occurs  Serious health condition and is classified
when the body has a response to an as someone having a BMI greater
infection that injures its own organs and than/equal to 40, or BMI greater than/equal
tissues to 35 with co-morbidities
 Sepsis can lead to shock, organ failure,
and death if it is not treated
 PATHOPHYSIOLOGY
 Sepsis usually stems from another medical
condition
 Invasive medical conditions can introduce
bacteria into the bloodstream
 4 main sites of infection that can lead to
sepsis: lungs, abdomen, kidney,
bloodstream
 Septic reaction will travel through the
vascular system and will spread
inflammation throughout the body
 Important to increase protein needs to
repair tissue
 SYMPTOMS/CLINICAL MANIFESTATIONS

 Flu-like symptoms for 48 hours; related to bloodstream infection

 Shortness of breath; decreased cardiac output
 Rash present under skinfolds; contributes to morbid obesity
 100 # weight loss in 4 months post Roux-en-Y Gastric Bypass
 Temp 102.4° F, high respiratory rate (23), elevated blood pressure (135/90)
 ETIOLOGY OF SEPSIS & MORBID OBESITY
 Sepsis
 Results from infection + SIRS with any 2 of the following:
-Body Temp >100.4 °F or <98.8 ° F
-Resting Heart Rate >90 bpm
-Respiratory Rate >20 breaths/min
-Hyperventilation
-Leukocytosis: WBC >12,000/mm^3 or <4,000/mm ^3
-Bandemia (excess immature WBC >10% in blood, indicator of infection)
 Common infections are from kidneys, blood, pneumonia, surgery, and some medical procedures
and derive from a low immune system.
 Severe Sepsis is sepsis with signs of Multiple Organ Dysfunction Syndrome (MODS),
hypotension, and lactate >4 mmol
https://www.youtube.com/watch?v=Ih1drKihnsQ
 ETIOLOGY CONTINUED
 Morbid Obesity
 BMI of 40 or >40, or BMI of 35 or greater with a co-morbidity
 Factors include:
 Physical inactivity
 Metabolism
 Poor diet
 Lifestyle
 Genetics
 Environment
 TREATMENT OF SEPSIS
 Remove/minimize trauma and infection
 Support hemodynamics
 Monitor his Mean Arterial Pressure (MAP)
 Renal function
 Respiratory function
 Nutrition support should be initiated to decrease severity of problem, decrease time
in the MICU, decrease infectious morbidity
 Monitor lab values
 TREATMENT OF MORBID OBESITY

 Low calorie diet, increased physical activity, lifestyle modifications

 Medications combined with lifestyle modifications
 Surgery with a diet and lifestyle modifications as prescribed
 Prevention of weight regain through nutritional monitoring and evaluation, goal setting, and
nutritional counseling
 NUTRITION INTERVENTION
 Nutrition Prescription
 Administer enteral tube feeding into small bowel
 Provide 1800-2000 mL of fluid as prescribed, trophic feeding
 Monitor labs
 Upon recovery of Sepsis, increase physical activity with a low-calorie diet to treat obesity

 Intervention
 Increase energy expenditure, increase PRO intake
 Nutritional counseling
 Establish goals, frequent appointments with RD for monitoring and evaluation of care plan
 PROGNOSIS

 Best Case
 Infection is absent, inflammatory response decreases, MAP returns to normal, no organ
damage.
 Median
 Lives with organ and tissue damage sensitive to brain, eyes, heart, and kidneys

 Worst Case
 Sepsis Severe Sepsis (MOD)Septic Shock Death
 Mr. McKinley is showing signs of kidney failure (↑ ammonia, ↑ ALT & AST, ↑ potassium, and
↑ bilirubin direct)
 DIAGNOSIS OF CURRENT ADMISSION

 37 y.o. Male, 5’10”, 325# admitted to ER and sent to MICU with probable sepsis
 Experiencing flu-like symptoms over past 48 hours, temp 102.5° F related to bloodstream
infection
 Shortness of breath related to the EBB phase in metabolic stress and decreased cardiac
output
 TESTS AND PROCEDURES REGARDING CURRENT
ADMISSION

 Serum lactate
 Helps with the diagnosis of sepsis; measures the acidity and electrolyte disturbances
within the body
 Basel metabolic panel
 Provides information about your body’s metabolism; measures sodium, chloride, BUN,
potassium, bicarbonate, chromium
 Hepatic function panel
 Measures liver function; CBC, EDIF, platelets
 Insert feeding tube via small bowel
 Awaiting culture labs
 MEDICATIONS AND SUPPLEMENTS

 Lovastatin 60 mg/day
 Used to treat high cholesterol and triglycerides
 Lantus & Metformin previously; off of these for 2 months
 Diabetic medications
 Vancomycin 2 g in sodium chloride IVPB
 Treats bacterial infections
 Zosyn
 Penicillin antibiotic

 Sedated with Versed and fentanyl

 NUTRITION ASSESSMENT
 IBW - (106 + (6x10)) + (235 – 164) = 237#, or 107.7kg
 %UBW - 76.46%
 Energy Needs - IJ: 1925- 10(37y.o) + 5(147.4kg) + 281(1) + 292(0) + 851 (0) = 2573 kCal
 ASPEN: 22kCal/kg= 22 x 107.7= 2369.4 kCal
 Average of the two is 2470kCal.
 PRO - 1.5-2.0 g/kg of IBW for obese.
 1.5g x 107.7kg = 162g of Pro
 2.0g x 107.7kg = 215g of Pro
 FAT - 2.5 g/kg X 147.4 kg = 369 g
 CHO - 321 g CHO from Promote X 1000 = 321,000 / 147.4 kg = 2,177 / 1440 = 1.51 mg/kg/min
 NUTRITION ASSESSMENT CONTINUED
 Biochemical Data
 Anthropometrics  CO2 high, PRO low
 Weight – 325 lbs.  Negative acute phase proteins are
 Height – 5’10” affected
 BMI – 46.7 (Obese class III)  Ammonia high, CPK high

 BP – 135/90 (high)  Positive acute phase proteins are high

 Resp rate – 23 (high)  Liver and kidney enzymes are affected

 Pulse – 98 bpm  High cholesterol levels

 Temp – 102.5 (high)  Low Hgb and Hct

 Protein, glucose, ketones all found in
urinalysis
 DIET HISTORY/FOOD HABITS

 None given; however, has been compliant with post Roux-en-Y gastric bypass
surgery diet for 4 months.
 (1-2 months post) Slow progression of food is necessary to prevent the onset
of early and late dumping syndrome.
 Eat small, frequent meals.
 High risk for dehydration and PRO malnutrition
 Socially, 2-3 beers/week
 NUTRITION DIAGNOSIS

 Inadequate PRO intake (NI-5.7.1) related to metabolic stress/sepsis as evidenced by

low Alb of 1.9 and Pre-Alb of 11.
 Increased energy expenditure (NI-1.2) related to metabolic stress/sepsis as
evidenced by low Alb of 1.9, high WBC of 23.5 and high CRP of 5.8.
 Inadequate energy intake (NI-1.4) related to gastric bypass surgery as
evidenced by %UBW of 76.46% and 100 pounds lost in 4 months.
 NUTRITION INTERVENTION
 Adjust Kcal intake to a hybrid of Ireton-Jones and ASPEN recommendations
of approximately 2470 Kcal
 Adjust CHO intake to comprise of approximately 50-55% of total intake
 Adjust PRO to 189g/d
 Limit Fat to no more than 30%.
 Trophic feeding for EN
 Formula choice: Promote
 Beneficial for patients who have experienced stress and trauma. It is high in protein,
sufficient in kcals, and not too high in fat
 In order to reduce the risk for dumping syndrome, we will provide trophic feeds, starting out
10 ml/hr and advancing 10 ml/hr q 4 hours.
 MONITORING AND EVALUATION

 Monitor acute phase proteins such as CRP and pre-alb to get an

understanding if PRO needs are being met
 Monitor serum glc due to the T2DM and sepsis induced hyperglycemia
 Need to also monitor presence of ketone bodies related to poor glc/insulin
management
 Observe weight changes and fluid retention
 Adjust EN as tolerated by Pt.
 Follow up on the above with new lab values that will be collected the next day
 CASE STUDY QUESTIONS
#6. Define refeeding syndrome. How will Mr. McKinley’s recent 100-lb weight
loss affect you nutrition support recommendations?
 Refeeding syndrome is a potentially fatal shift of fluids and electrolytes that may occur in
malnourished patients receiving enteral/parenteral nutritional support. The fluid shifts create
hormonal and metabolic changes that can cause serious clinical complications.
 CHO and Fat intake must be decreased and protein intake increased. He also needs to be
fed in small, frequent amounts by slowly re-introducing nutrition and provide supplemental
phosphate and magnesium.
 Since Mr. McKinley also has T2DM it is wise to want to control his blood sugar for insulin
correction. Some laboratory values to monitor are his glucose, magnesium, potassium, and
phosphorous
 CASE STUDY QUESTIONS
#11. Determine Mr. McKinley’s energy and protein requirements. Explain the
rationale for the method you used to calculate these requirements.
 For energy needs, we used the Ireton-Jones equation using his actual body weight, as well as the
ASPEN guidelines. This is because Mr. McKinley is on mechanical ventilation and his sepsis, metabolic
stress condition, is the most important area to focus on to make sure he is getting adequate energy
intake and protein intake to help fight the infection.
 1925 – 10 (37) + 5 (147.73 kg) + 281 (1) + 292 (0) + 851 (0)
 1925 – 370 + 738.65 + 281 = 2,575 kcals
 ASPEN: 22kCal/kg = 22 x 107.7= 2369.4 kCal
 Average of the two is 2470 kCal.
 For protein needs, we used 1.5-2.0 g/kg using IBW for Mr. McKinley. This is because he is obese and
has an infection
 1.5g x 107.7kg = 162g of Pro
 2.0g x 107.7kg = 215g of Pro