Dampak Narkoba Bagi Kesehatan

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Otak Dan Adiksi

By
Yuliyanti Setiawati
Permasalahan
Penyalahgunaan Narkoba
• Indonesia pasar
potensial peredaran
gelap narkoba
• Jumlah penyalahguna
semakin meningkat
• Adiksi merupakan
masalah Public Health
• Adiksi adalah “Brain
Disease”
Neurotoxicity
AIDS, Cancer
Mental illness,
Hepatitis

Homelessness Health care


Crime Productivity
Violence Accidents
Why Do People Take Drugs in The
First Place?

To Feel Good To Feel Better


feelings To lessen:
sensations anxiety
experiences worries
AND fears
to share them depression
hopelessness
Your Brain on Drugs Today

YELLOW
shows places in
brain where
drugs binds
(e.g., striatum)

Fowler et al., Synapse, 1989.


Addiction is Like Other Diseases…
 It is preventable
 It is treatable
 It changes biology
 If untreated, it can last a lifetime
Decreased Brain Metabolism Decreased Heart Metabolism
in Drug Abuser in Heart Disease Patient
High

Low
Healthy Brain Diseased Brain/ Healthy Diseased Heart
Cocaine Abuser Heart

Research supported by NIDA addresses all of these


components of addiction.
Movement

Motivation

Dopamine

Addiction Reward & well-being


dopamine
transporters
But Dopamine is only Part of the Story

• Scientific research has shown that other


neurotransmitter systems are also affected:
– Serotonin
• Regulates mood, sleep, etc.
– Glutamate
• Regulates learning and memory, etc.
Functionally…
Dopamine D2 Receptors are Decreased by Addiction

Cocaine

Meth

Alcohol

Heroin
Control Addicted
Konsekuensi dari perubahan di otak

• Gangguan mental dan


perilaku
Pengaruh Terhadap Hati
• Hepatitis B
• Hepatitis C
• Sirrosis hati
Kanker hati
HIV / AIDS
• Terutama IDU
• Infeksi Oportunistik
• Butuh dukungan
keluarga
• Rutin terapi ARV
4 dari 10 kematian AIDS
berhubungan dengan Drug Abuse
Wajah drugs abuser
TERIMA KASIH

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