Drugs Acting in CVS
Drugs Acting in CVS
Drugs Acting in CVS
BP = CO × PVR
Regulation of cardiac output and peripheral
vascular resistance, exerted at three anatomic
sites:
arterioles
postcapillary venules (capacitance vessels)
heart
kidney
Normal Regulation of Blood Pressure
A. Short term
1. Baroreceptor Reflex
2. Chemoreceptor Reflex
3. Hormones: Epinephrine and
Norepinephrine
ANP
ADH
B. Long Term
1. Renin Angiotensin Aldosterone(RAA)
System
Cardiovascular Center in Medulla
Oblongata
Control Center for Heart and Blood Vessels
A. Cardiac Center
Autonomic control of the Heart
-Cardioaccelatory center:
sympathetic
- Cardioinhibitory center:
parasympathetic
B. Vasomotor Center
Central Chemoreceptors
in the medulla monitor mainly
pH of CSF (which is affected by CO2)
EFFECT OF HORMONES
EPINEPHRINE AND
-produced by the Adrenal Gland NOREPINEPHRINE
• Vasoconstriction of vessels
Kidney
-Primarily responsible for long-term blood
pressure control.
Drugs to Treat Heart Failure
HEART FAILURE