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    Gastritis

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    Mario
    Gastritis is an inflammation of the stomach lining that can be acute or chronic, with common causes being H. pylori bacterial infection, NSAID use, alcohol, and stress. Symptoms include nausea, abdominal pain, and indigestion. H. pylori infection leads to gastritis by secreting urease to create an alkaline environment that promotes bacterial survival and releases toxins that damage the stomach lining.

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    Gastritis

    Uploaded by

    Mario
    499 views10 pages
    Gastritis is an inflammation of the stomach lining that can be acute or chronic, with common causes being H. pylori bacterial infection, NSAID use, alcohol, and stress. Symptoms include nausea, abdominal pain, and indigestion. H. pylori infection leads to gastritis by secreting urease to create an alkaline environment that promotes bacterial survival and releases toxins that damage the stomach lining.

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    Gastritis is an inflammation of the stomach lining that can be acute or chronic, with common causes being H. pylori bacterial infection, NSAID use, alcohol, and stress. Symptoms include nausea, abdominal pain, and indigestion. H. pylori infection leads to gastritis by secreting urease to create an alkaline environment that promotes bacterial survival and releases toxins that damage the stomach lining.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    499 views10 pages

    Gastritis

    Uploaded by

    Mario
    Gastritis is an inflammation of the stomach lining that can be acute or chronic, with common causes being H. pylori bacterial infection, NSAID use, alcohol, and stress. Symptoms include nausea, abdominal pain, and indigestion. H. pylori infection leads to gastritis by secreting urease to create an alkaline environment that promotes bacterial survival and releases toxins that damage the stomach lining.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 10

    GASTRITIS

    • Gastritis is an inflammation, irritation, or


    erosion of the lining of the stomach /
    gastric mucosa. It can occur suddenly
    (acute) or gradually (chronic).

    RISK FACTOR OF GASTRITIS


     H. pylori infection
     Regular use of aspirin or other NSAIDs
     Older age
    ETIOLOGY OF GASTRITIS
    • Bacterial infection
    • Regular use of pain relievers
    • Excessive alcohol use
    • Stress
    • Bile reflux disease
    • Your own body attacking cells in your stomach
    (autoimmune gastritis)
    • Other diseases and conditions
    CLASSIFICATION OF GASTRITIS
    • Acute gastritis
    – Acute H. pylori infection
    – Other acute infectious gastritis
    • Chronic atrophic gastritis
    – Type A
    – Type B
    – Indeterminant
    • Uncommon forms of gastritis
    – Lymphocytic
    – Eosinophilic
    – Crohn’s disease
    – Sarcoidosis
    – Isolated granulomatous gastritis
    SYMPTOMS OF GASTRITIS
    • Nausea or recurrent upset stomach
    • Abdominal bloating
    • Abdominal pain
    • Vomiting
    • Indigestion
    • Burning or gnawing feeling in the stomach
    between meals or at night
    • Vomiting blood or coffee ground-like material
    • Black, tarry stools
    Infection of H. PILORY

    gastritis TH 1 motility
    H.Pylory
    infects gaster
    urease
    protective TH2
    Vac A Urea
    ammonia
    +CO2
    Provides a survival needs for bacteria
    Causes epithelial injury
    Pathogenesis of Helicobacter pylori infection

    • An ability to colonize and adhere to gastric


    epithelial cells.
    • The possesion of flagella that allows movement
    through the luminal mucous layer to site of higher
    Ph.
    • An ability of adherent strains to supress acid
    secretion to improve their survival.
    • Secretion of urease that produces ammonia
    results in a more alkaline environment.
    • Release of vacuolating cytotoxin (VacA) that
    promotes bacterial survival and causes epithelial
    injury.
    • The presence of cytotoxin-assosiated gene (CagA) strains that can escape
    normal immune responses and cause inflammation with release of
    inflammatory cytokines and reactive oxygen metabolites that damages
    mucosal epitelial cells and loss of the protective mucosal barrier.
    • Recruitment and activation of neutrophils,macrophages,and mast cells
    with release of inflammatory cytokines that promote celllar injury.
    • Down-regulation of antral somatostatin leading to increased
    gastrin,acid,impaired mucosal bicarbonat production and increased
    mucosal exposure to acid and pepsin.
    • Activation/inhibition of T-and B- cell immune
    responses that may contribute to mucosal
    injury.
    • Release of cytokines and chemokines that
    promote gastric epithelial cell death and cell
    proliferation that can result in
    atrophy,ulcers,or malignant growth.
    Examination
    • Urea breath test
    • Serologi
    • Biopsy urea test
    • Manifestacion:
    – Burn feeling (in epigastrium)
    – Nausea
    – Bitter in the tounge
    – Disfagia

    Complication:
    Esophagitis is classified into the following 4
    gradesI,II,III,IV.

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