Qualitative Platelet Disorders: Direndegen Omaira R. Sampiano Johannah B
Qualitative Platelet Disorders: Direndegen Omaira R. Sampiano Johannah B
Qualitative Platelet Disorders: Direndegen Omaira R. Sampiano Johannah B
Direndegen Omaira R.
Sampiano Johannah B.
Thrombocytopathy
• INHERITED
• ACQUIRED
INHERITED DEFFECT
• Adhesion
• Aggregation
• Secretion
Adhesion Defect
Pathophysiology
• Fibrinogen is a necessary cofactor for the aggregation of
human platelets by ADP.
• Type I: The platelets lacking Gp Iib-IIIa as well as
intraplatelet fibrinogen.
• Type II: Platelet contain subabnormal levels of
fibrinogen and the amount of Gp Iib-IIIa complexes is
around 15% of normal.
Clinical Pictures
▫ Bruising
▫ Epistaxis
▫ Bleeding from mucuos membrane
▫ Gastrointestinal bleeding
▫ Menorrhagia
• Rare disorders
• A plasma defect that will cause a platelet
aggregation disorder similar to
Glanzmann’s thrombasthenia.
Release Disorders
Chediak-Higashi anomaly
• A albinism, re-current infections, and giant lysosomes in
all granules containing cells.
• The ratio of ATP to ADP in these platelet is consistent
with a beta-granule deficiency.
• It is secondary wave of aggregation that is abnormal or
absent.
Granules Release Defect