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    Medicinal Chemistry-I: Question /answer Session

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    Rahul
    The document provides information about an upcoming question/answer session on Medicinal Chemistry-I for students of pharmacy. It includes a disclaimer noting attendance is compulsory and students should take detailed notes. The syllabus for the course is also outlined, covering topics like introduction to medicinal chemistry, drugs acting on the autonomic nervous system, central nervous system, and more. The question paper pattern is also stated, involving multiple choice questions, long answers, and short answers worth a total of 70 marks. Sample multiple choice questions are then provided to help students prepare.

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    Medicinal Chemistry-I: Question /answer Session

    Uploaded by

    Rahul
    144 views21 pages
    The document provides information about an upcoming question/answer session on Medicinal Chemistry-I for students of pharmacy. It includes a disclaimer noting attendance is compulsory and students should take detailed notes. The syllabus for the course is also outlined, covering topics like introduction to medicinal chemistry, drugs acting on the autonomic nervous system, central nervous system, and more. The question paper pattern is also stated, involving multiple choice questions, long answers, and short answers worth a total of 70 marks. Sample multiple choice questions are then provided to help students prepare.

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    Final Q. Bank All in One MC-I 2021-1

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    The document provides information about an upcoming question/answer session on Medicinal Chemistry-I for students of pharmacy. It includes a disclaimer noting attendance is compulsory and students should take detailed notes. The syllabus for the course is also outlined, covering topics like introduction to medicinal chemistry, drugs acting on the autonomic nervous system, central nervous system, and more. The question paper pattern is also stated, involving multiple choice questions, long answers, and short answers worth a total of 70 marks. Sample multiple choice questions are then provided to help students prepare.

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    © All Rights Reserved
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    Download as pptx, pdf, or txt
    144 views21 pages

    Medicinal Chemistry-I: Question /answer Session

    Uploaded by

    Rahul
    The document provides information about an upcoming question/answer session on Medicinal Chemistry-I for students of pharmacy. It includes a disclaimer noting attendance is compulsory and students should take detailed notes. The syllabus for the course is also outlined, covering topics like introduction to medicinal chemistry, drugs acting on the autonomic nervous system, central nervous system, and more. The question paper pattern is also stated, involving multiple choice questions, long answers, and short answers worth a total of 70 marks. Sample multiple choice questions are then provided to help students prepare.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 21

    Question /Answer Session

    Medicinal Chemistry-I
    S. Y. B. Pharm. Sem IV (2020-21)

    K. K. Wagh Education Society’s

    K. K. Wagh College of Pharmacy


    (Affiliated to Dr. Babasaheb Ambedkar Technological University)
    07/29/2021 Prof. M. G. Shinde & Prof. S. D.Malode 1
    Disclaimer
    1. Attendance for this Q.A. Session is 100% Compulsory.

    2. Separate Note book should be prepared and all Q.A to be noted down
    carefully.

    3. These are very carefully selected & prepared Q & A by your teachers

    4. So, prepare and recite them without fail

    5. Strict Disciplinary Action shall be taken against those who not abide by
    above points as well as remain absent, including calling parents 2

    07/29/2021
    Syllabus for MC-I theory
    Unit I
    Introduction to Medicinal Chemistry
    History and development of medicinal chemistry,
    Physicochemical properties in relation to biological action- Ionization, Solubility, Partition
    Coefficient, Hydrogen bonding, Protein binding, Chelation, Bioisosterism, Optical and
    Geometrical isomerism.
    Drug metabolism Drug metabolism principles- Phase I and Phase II. Factors affecting drug
    metabolism including stereo chemical aspects
    Unit II
    • Drugs acting on Autonomic Nervous System
    Adrenergic Neurotransmitters: Biosynthesis and catabolism of catecholamine. Adrenergic receptors
    (Alpha & Beta) and their distribution.
    Sympathomimetic agents: SAR of Sympathomimetic agents
     Direct acting: Nor-epinephrine, Epinephrine, Phenylephrine*, Dopamine, 89 Methyldopa,
    Clonidine, Dobutamine, Isoproterenol, Terbutaline, Salbutamol*, Bitolterol, Naphazoline,
    Oxymetazoline and Xylometazoline.
     Indirect acting agents: Hydroxyamphetamine, Pseudoephedrine, Propylhexedrine.
     Agents with mixed mechanism: Ephedrine, Metaraminol. .
    07/29/2021 3
    Prof M.G.Shinde
    Syllabus for MC-I theory
    Unit II
    Adrenergic Antagonists:
    Alpha adrenergic blockers: Tolazoline*, Phentolamine, Phenoxybenzamine, Prazosin,
    Dihydroergotamine, Methysergide.
    Beta adrenergic blockers: SAR of beta blockers, Propranolol*, Metibranolol, Atenolol,
    Betazolol, Bisoprolol, Esmolol, Metoprolol, Labetolol, Carvedilol.

    Unit III
    Cholinergic neurotransmitters: Biosynthesis and catabolism of acetylcholine. Cholinergic
    receptors (Muscarinic & Nicotinic) and their distribution.
    Parasympathomimetic agents: SAR of Parasympathomimetic agents
    Direct acting agents: Acetylcholine, Carbachol*, Bethanechol, Methacholine, Pilocarpine.
    Indirect acting/ Cholinesterase inhibitors (Reversible & Irreversible): Physostigmine,
    Neostigmine*, Pyridostigmine, Edrophonium chloride, Tacrine hydrochloride, Ambenonium
    chloride, Isofluorphate, Echothiophate iodide, Parathione, Malathion. Cholinesterase
    reactivator: Pralidoxime chloride.

    07/29/2021 Prof M.G.Shinde/ Prof. S.D.Malode 4


    Syllabus for MC-I theory
    Unit III
    Cholinergic Blocking agents: SAR of cholinolytic agents
    Solanaceous alkaloids and analogues: Atropine sulphate, Hyoscyamine sulphate, Scopolamine
    hydrobromide, Homatropine hydrobromide, Ipratropium bromide*.
    Synthetic cholinergic blocking agents: Tropicamide, Cyclopentolate hydrochloride, Clidinium
    bromide, Dicyclomine hydrochloride*, Glycopyrrolate, Methantheline bromide, Propantheline
    bromide, Benztropine mesylate, Orphenadrine citrate, Biperidine hydrochloride, Procyclidine
    hydrochloride*, Tridihexethyl chloride, Isopropamide iodide, Ethopropazine hydrochloride.
    Unit IV
    Drugs acting on Central Nervous System
    A. Sedatives and Hypnotics:
    Benzodiazepines: SAR of Benzodiazepines, Chlordiazepoxide, Diazepam*, Oxazepam,
    Chlorazepate, Lorazepam, Alprazolam, Zolpidem
    Barbiturtes: SAR of barbiturates, Barbital*, Phenobarbital, Mephobarbital, Amobarbital,
    Butabarbital, Pentobarbital, Secobarbital
    Miscelleneous: Amides & imides: Glutethmide. Alcohol & their carbamate derivatives:
    Meprobomate, Ethchlorvynol.
    Aldehyde & their derivatives: Triclofos sodium, Paraldehyde.
    07/29/2021 5
    Prof M.G.Shinde
    Syllabus for MC-I theory
    Unit IV
    Drugs acting on Central Nervous System
    B. Antipsychotics
     Phenothiazeines: SAR of Phenothiazeines - Promazine hydrochloride, Chlorpromazine
    hydrochloride*, Triflupromazine, Thioridazine hydrochloride, Piperacetazine hydrochloride,
    Prochlorperazine maleate, Trifluoperazine hydrochloride.
     Ring Analogues of Phenothiazeines: Chlorprothixene, Thiothixene, Loxapine succinate, Clozapine.
     Fluro buterophenones: Haloperidol, Droperidol, Risperidone.
     Beta amino ketones: Molindone hydrochloride.
     Benzamides: Sulpieride.
    C. Anticonvulsants: SAR of Anticonvulsants, mechanism of anticonvulsant action
     Barbiturates: Phenobarbitone, Methabarbital.
     Hydantoins: Phenytoin*, Mephenytoin, Ethotoin
     Oxazolidine diones: Trimethadione, Paramethadione
     Succinimides: Phensuximide, Methsuximide, Ethosuximide*
     Urea and monoacylureas: Phenacemide, Carbamazepine*
     Benzodiazepines: Clonazepam
     Miscellaneous: Primidone, Valproic acid , Gabapentin, Felbamate
    07/29/2021 6
    Prof M.G.Shinde
    Syllabus for MC-I theory
    Unit V
    Drugs acting on Central Nervous System
    General anesthetics:
    Inhalation anesthetics: Halothane*, Methoxyflurane, Enflurane, Sevoflurane, Isoflurane,
    Desflurane. Ultra short acting barbitutrates: Methohexital sodium*, Thiamylal sodium, Thiopental
    sodium. Dissociative anesthetics: Ketamine hydrochloride.*
    Narcotic and non-narcotic analgesics
    Morphine and related drugs: SAR of Morphine analogues, Morphine sulphate, Codeine,
    Meperidine hydrochloride, Anilerdine hydrochloride, Diphenoxylate hydrochloride, Loperamide
    hydrochloride, Fentanyl citrate*, Methadone hydrochloride*, Propoxyphene hydrochloride,
    Pentazocine, Levorphanol tartarate.
    Narcotic antagonists: Nalorphine hydrochloride, Levallorphan tartarate, Naloxone hydrochloride.
    Anti-inflammatory agents:
    Sodium salicylate, Aspirin, Mefenamic acid*, Meclofenamate, Indomethacin,
    Sulindac, Tolmetin, Zomepriac, Diclofenac, Ketorolac, Ibuprofen*, Naproxen, Piroxicam,
    Phenacetin, Acetaminophen, Antipyrine, Phenylbutazone

    07/29/2021 7
    Prof M.G.Shinde
    Question Paper Pattern
    Q I. Multiple Choice Questions (MCQs) = 20 x 1 = 20
    (Answer all the questions)
    OR
    Q I. Objective Type Questions (10 x 2) = 10 x 2 = 20
    (Answer all the questions)
    Q 2. Long Answers (Answer 2out of 3) = 2x 10 = 20
    Q 3. Short Answers (Answer 7 out of 9) = 2 x 5 = 10
    Total = 70 marks

    07/29/2021 Prof M.G.Shinde/ Prof. S.D.Malode 8


    MULTIPLE CHOICE QUESTIONS
    (M.C.Qs)

    Some questions have more than one correct answer.


    Select the best answer or answers from the choices given.

    Marks 01 Each
    07/29/2021 Prof M.G.Shinde/ Prof. S.D.Malode 9
    Q.No.1 M.C.Q. 1 mark each
    1*. Bioisoterism is the process of :
    (a) Replacement of similar group (b) Replacement of Similar mass (c) Replacement of similar
    valence group (d) Addition of different mass number group
    Correct : (c) Replacement of similar valence group

    2*. Dimercaprol is Chelating agent and used in treatment of...


    a)Arsenic Poisoning b)Iron Poisoning c) Lead Poisoning d) Vanadium Poisoning
    Correct : a)Arsenic Poisoning

    3*. Phase –I Reactions are also called as ………


    a) Biotransformation
    b) Functionalization reaction
    c) Conjugation Reaction
    d) Reduction Reaction
    Correct : b) Functionalization reaction
    07/29/2021 Dr. R.D.Amrutkar / Prof M.G.Shinde
    M.C.Q 10
    4. Azo and nitro groups are metabolized by….. Recation
    a) Acetylation b) Oxidation c) Hydrolysis d) Reduction
    Correct : d) Reduction

    5*. Which of the following metabolic reaction forms unstable hemiacetal or hemiketal intermediate
    a) N-hydroxylation b) o-dealkylation C) N-oxidation d) Reduction
    Correct : C) N-oxidation

    6. Which of the following is factor affecting drug metabolism


    a) Environmental Factor
    b) Genetic factor
    c) Chemical factor
    d) All of these
    Correct : d) All of these

    07/29/2021 Dr. R.D.Amrutkar / Prof M.G.Shinde


    M.C.Q 11
    • 7. A _____ is a drug that is intended to induce sleep by depressing the central nervous
    system.
    a)Antipsychotics
    b)Sedatives
    c)None of the above
    d) Hypnotics

    Correct : d. Hypnotics

    8 Which of the following is tricyclic antipsychotic having propyl dialkylamino side chain?
    a. Trifluoropramozine
    b. Haloperidol
    c. Sulpiride
    d. Thiothixene
    Correct Answer: Trifluoropramozine

    07/29/2021 Dr. R.D.Amrutkar / Prof M.G.Shinde


    M.C.Q 12
    9. Anxiolytics are also called as ..

    a. Antipanic
    b. Hypnotics
    c. Sedatives
    d. All of the above
    Ans: a Antipanic
    10. When malonic acid esters are condensed with ………..it give barbiturates

    a. Urea or Thiourea

    b. Alcohols

    c. Ethers

    d. Esters

    Ans: a. Urea or Thiourea


    11. Zolpidem contains which heterocyclic ring system….

    a. Imidazo [1,2-b] Pyridine

    b. Imidazo [2,3-b] Pyridine

    c. Imidazo [1,2-b] Pyrimidine

    d. Imidazo [1,2-b] Pyrazole

    Ans: a. Imidazo [1,2-b] Pyridine


    12. Nitrazepam contains which heterocyclic ring system

    a. 1,5-benzodiazepam

    b. 1,3-benzodiazepam

    c. 1,2-benzodiazepam

    d. 1,4-benzodiazepam

    Ans: d. 1,4-benzodiazepam
    13. Which of the following drug not comes under sedative and hypnotics Class?

    a. Chloral Hydrate

    b. Paraldehyde

    c. Glutetheamide

    d. None of the above

    Ans: d. None of the above


    14. Replacement of C=O with C=S in barbiturate structure gives ?

    a. Long on set of action


    b. Longer duration of action
    c. Short duration of action
    d. Abolish the activity
    Ans: Short duration of action
    15. Unsubstituted 5th position barbituric acid is ?
    a. Short acting
    b. Long acting
    c. Not active
    d. Long active
    Ans: Not active
    16. Saturation of double bond at 4,5 position of benzodiazepine will..?

    a. Increases the activity

    b. Reduces the activity

    c. Abolishes the activity

    d. Not affect the activity of parent molecule

    Ans: Reduces the activity


    Thank you

    07/29/2021 Prof.S.D.Malode 21

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