Cranial Nerves

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CRANIAL NERVES

Origin of the Cranial Nerves

• There are twelve pair of cranial nerves in total. The olfactory nerve (CN I)
and optic nerve (CN II) originate from the cerebrum.
• Cranial nerves III – XII arise from the brain stem . They can arise from
a specific part of the brain stem (midbrain, pons or medulla), or from a
junction between two parts:
• Midbrain – the trochlear nerve (IV) comes from the posterior side of the
midbrain. It has the longest intracranial length of all the cranial nerves.
• Midbrain-pontine junction – oculomotor (III).
• Pons – trigeminal (V).
• Pontine-medulla junction – abducens, facial, vestibulocochlear (VI-VIII).
• Medulla oblongata – posterior to the olive: glossopharyngeal, vagus,
accessory (IX-XI). Anterior to the olive: hypoglossal (XII)
Modalities

• Each cranial nerve can be described as being sensory, motor or both.


• Sensory (afferent) Modalities:
• General somatic sensory (GSS) – general sensation from skin.
• General visceral sensory (GVS) – general sensation from viscera.
• Special somatic sensory (SSS) – senses derived from ectoderm (e.g. sight,
sound, balance).
• Special visceral sensory (SVS) – senses derived from endoderm (e.g. taste,
smell).
• Motor (efferent) Modalities:
• General somatic motor (GSM) – skeletal muscles.
• General visceral motor (GVM) – smooth muscles of gut and autonomic
motor.
• Special visceral motor (SVM) – muscles derived from pharyngeal arches.
CN 1 Olfactory
Cribriform plate Sensory(SVS) Smell

CN 2 Optic Optic canal Sensory(SSS) Vision


CN 3 Oculomotor GSM: 4 extrinsic eye
muscles and levator
Superior orbital fissure Motor(GSM palpebrae
& GVM)
superioris.GVM:
pupillary sphincter
CN 4 Trochlear Superior orbital fissure Motor(GSM) Superior oblique
CN 5

Scalp, forehead and


nose.
Cheeks, lower eye lid,
nasal mucosa, upper
Trigeminal lip, upper teeth and
Ophthalmic Superior orbital fissure GSS
palate.
Maxillary F. Rotundum GSS
Mandibular F. ovale GSS,SVM GSS: anterior 2/3
tongue, skin over
mandible and lower
teeth.
SVM: muscles of
mastication.
CN 6 Abducens
Superior
Motor(GSM) Lateral rectus
orbital fissure

CN 7 Facial
GSS: sensation to part of
ext. ear.SVS: taste from
ant. 2/3 tongue, hard
Internal Both:GSS and soft palate.
acoustic SVS SVM: muscles of facial
expression.
meatus > SVM
GVM: lacrimal,
stylomastoid f. GVM submandibular,
sublingual glands and
mucous glands of mouth
and nose.

CN 8 Vestibulocochle Internal
ar acoustic Sensory(SSS) Hearing and balance
meatus
CN 9 Glossopharynge
al GSS: post. 1/3 tongue,
ext. ear, and middle ear
Both:GSS
GVS cavity.GVS: carotid body
Glossopharyng and sinus.
eal Jugular f. SVS SVS: taste from post. 1/3
GVM
SVM tongue.
GVM: parotid gland.
SVM: stylopharyngeus
CN 10 GSS: ext. ear, larynx and pharynx.GVS:
Both:GSS larynx, pharynx and, thoracic & abdominal
Jugular GVS viscera.
Vagus SVS SVS: taste from epiglottis region of tongue
f.
GVM GVM: smooth muscles of pharynx, larynx
SVM and most of the GIT.
SVM: most muscles of pharynx and larynx.
CN 11 Spinal GSM: trapezius and
Jugular Motor(GS
access sternocleidomastoid.SVM: a few fibres run
ory f. M & SVM) with CNX to viscera.
CN 12 Hypoglo
Hypogl Motor(GS Intrinsic and extrinsic tongue muscles
ossal ssal M) (except the palatoglossus).
canal
CRANIAL NERVE NUCLEI
• The cranial nerve nuclei are made up of the
neurons in the brainstem that receive primary
sensory inputs or that give rise to motor
outputs. 
The Edinger–Westphal nuclei
• The Edinger–Westphal nuclei controls the
pupillary light reflex and accommodation
responses of the lens
THE OCULOMOTOR NUCLEUS
• The oculomotor nucleus helps to adjust and
coordinate eye position during movement
through oculomotor nerve.
Paramedian Pontine Reticular Formation

• The abducens nucleus is the key pathway for


conjugate horizontal gaze movements.
• The nucleus contains abducens motor
neurons, internuclear neurons, and neurons
that project to the paramedian tracts (PMT).
• The paramedian pontine reticular formation
(PPRF) is the brainstem structure responsible
for generating horizontal conjugate gaze.
Medial Longitudinal Fasciculus

• The medial longitudinal fasciculus (MLF) is a


fiber tract that extends from the spinal cord to
the oculomotor nerve nucleus. It contains
primarily ascending fibers.
• An abnormality of the MLF causes problems
with horizontal, vertical, and torsional gaze
coordination of the two eyes.
Rostral Interstitial Nucleus of the Medial Longitudinal Fasciculus

• The rostral interstitial nucleus of the medial longitudinal


fasciculus (riMLF) is appears to be the immediate premotor
area for vertical fast eye movements, upward and
downward, as well as torsional.
• These nuclei project to the trochlear nerve and oculomotor
nerve nuclei. Its function is thus analogous to the PPRF for
vertical eye movements.
• Lesions of this are produce the ocular tilt reaction: an
ipsilateral head tilt with depression and extorsion of the
ipsilateral eye and an elevation and intorsion of the
contralateral eye.
Posterior Commissure and Nucleus of the Posterior Commissure

• Lesions in this region produce abnormalities of


upward gaze.
• Involvement of the posterior commissure may be
part of the dorsal midbrain syndrome (Parinaud
syndrome). In this syndrome, there is impairment of
upwardly directed saccades or, in extreme cases, loss
of all vertical movement.
• Other signs include pupillary mydriasis and light-
near pupillary dissociation, corectopia, and
convergence-retraction nystagmus.
Superior Colliculus

• play a role in both ocular motor and sensory


function. The superior colliculus receives visual input
directly from branches of retinal ganglion cell axons.
Visual input also comes indirectly from the visual
cortex, the parietal and frontal lobes, and the
substantia nigra. There are efferent projections to
the brainstem premotor areas, both PPRF and riMLF.
• The superior colliculus can generate visually directed
saccades independently and may play a role in the
control of pursuit eye movements.
Cerebellum

• The cerebellum is involved in the modulation


of all types of eye movements.
• stabilizing eye on an object (gaze holding),
• smooth pursuit,
• combined head and eye tracking,
• saccade and
• adjustment of the vestibule-ocular reflex.

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