Minerals Iron by Dr. Faisal Hassan Shah (06.04.2020)
Minerals Iron by Dr. Faisal Hassan Shah (06.04.2020)
Minerals Iron by Dr. Faisal Hassan Shah (06.04.2020)
lecture 1
Iron
DR FHSHAH
Learning Objectives
What is iron.
Functions of iron
protein globin.
Catalases:
A haem containing enzyme.
fibres.
-SH.
Catalase and Glutathione peroxidase
reduced glutathione.
.
H2O2
Succinate dehydrogenase,
Aconitase,
Ribonucleotide reductase
Haber’s reaction.
as Haber’s reaction.
B. Storage Iron
1. Ferritin
2. Haemosiderin.
1. Ferritin
weight of 550,000.
Apoferritin is an interesting compound in that it
spherical shell.
Apoferritin
maximum.
Haemosiderin
carrier of iron.
TRANSFERRIN
Legumes,
Molasses,
(Garnick’s hypothesis).
ABSORPTION
Glutathione, and
Individuals having
1)Achlorhydria or achylia gastrica
as required.
TRANSFERRIN
Note
1. In the last trimester of pregnancy, the fetus
sequesters Fe from the mother at an average rate of
3 to 4 mg/day.
.
Iron in women
Biochemically the
serum ferritin is low↓ and
transferrin saturation is low↓.
Erythrocyte protoporphyrin↑ increases, as
erythropoiesis is slowed down due to nonavailability of
Fe which cannot be incorporated in protoporphyrin IX.
Haemoglobin concentration falls↓ to the lowest
limit of normal.
3. Iron Deficiency Anaemia
Note:
Early diagnosis of haemochromatosis is
essential.
.
Untreated Haemochromatosis
can lead to
Liver,
Pancreatic and cardiac impairment,
Diabetes mellitus, and hepatic carcinoma.
• A helpful screening test is: Serum transferrin
saturation.
• Inherited disorder
• Autosomal recessive
:
1.Hereditary defect in regulation of iron
absorption by the duodenum and jejunum.
idiopathic haemochromatosis .
2.Erythrogenesis imperfecta or
this condition.
.
• Idiopathic pulmonary haemosiderosis