Anti - TB Drugsupdated
Anti - TB Drugsupdated
Anti - TB Drugsupdated
These include:
Mycobacterium tuberculosis (tuberculosis)
1. Mycobacterium leprae (leprosy)
2. Atypical mycobacteria (with various clinical
presentations)
TUBERCULOSIS
what is TB???
Causative agent???
ANTI _TB DRUGS
INITIAL PHASE
At least 3 drugs for at least 8 weeks.
CONTINUATION PHASE
After initial phase only 2 drugs for rest of
period
ISONIAZID OR INH
CHEMISTRY: Structural congener of pyridoxine
RESISTANCE??
INH PHARMACOKINETICS
METABOLISM:
Liver
acetylation (slow/fast)
Half life (3-4h / 60-90m)
Metabolism (acetylation) in liver
Allergic reactions
Fever. Skin rashes
Drug induced SLE
Direct toxicity
1. Liver
2. Neurotoxicity
a.peripheral neuropathy (B6 supplementation)
b.seizures
3. Haematological system
1. Liver:- most frequent & major toxic ef-
fect
INH induced hepatitis
RESISTANCE??
CLINICAL USE & DOSAGE ORAL OR
BY INJ.
A) In active disease combine with ethambutol, rifampin
or streptomycin.
Max adult dose 300 mg daily (5 mg/kg/day)
Pyridoxine 10 mg/100 mg of INH given along
with to prevent ? …….
B) Prophylactic use (latent TB)
STANDARD REGIMEN:
RIP (2M)
RI (4M)
ALTERNATIVE REGIMEN:
RI (9M)
IE (18M)