Definition
Definition
Definition
Glucuronidation
The mechanism by which the liver conjugates bilirubin
1.Definition of bilirubin
2.Bilirubin formation
3.Bilirubin metabolism
4.Excretion through intestine
Definition of bilirubin
Bilirubin is a yellowish pigment produced
during the breakdown of the red blood cell.
It is processed by the liver and excreted in the
bile, playing a crucial role in the body’s waste
elimination process.
Bilirubin formation
Bilirubin is formed during the breakdown of heme, a component
of hemoglobin found in red blood cells. The process involves
several steps:
Hemolysis : Aging red blood cells are broken down in the
spleen, releasing heme.
Heme Breakdown:
Heme is enzymatically converted into biliverdin by the enzyme
heme oxygenase. This step releases carbon monoxide, iron, and
biliverdin.
Bilirubin Formation
Biliverdin to Bilirubin:
Biliverdin is then converted into bilirubin by the enzyme
biliverdin reductase. This reaction also produces more carbon
monoxide.
Excretion:
Conjugated bilirubin is then excreted into bile, stored in the
gallbladder, and eventually released into the small intestine.
Bilirubin Formation
Plasma
Hemoglobin
spleen
Globin
Heme Protein and AA pool
7. Intestinal bacteria
8. Excretion in feces
9. Urobilinogen in urine
Bilirubin Metabolism