An explosion at a chemical plant in Seveso, Italy in 1976 released toxic clouds containing dioxins over nearby areas. Immediate effects included skin lesions and illness in people and damage to vegetation. Long-term health impacts included liver damage, immune system problems, and increased cancer rates. Soil in contaminated zones was removed and buried in concrete pits as a countermeasure. The disaster led to new regulations like the Seveso Directive to prevent chemical accidents and limit environmental and health impacts.