MDM4 regulator of p53 (Q21109171)

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mammalian protein found in Homo sapiens
  • MDM4
  • MDM4 protein variant G
  • p53-binding protein Mdm4
  • double minute 4, human homolog of; p53-binding protein
  • Mdm4 p53 binding protein homolog
  • Double minute 4 protein
  • protein Mdm4
  • MDM4 protein variant Y
  • MDM4-related protein 1
  • mdm2-like p53-binding protein
  • protein Mdmx
  • MDM4, p53 regulator
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Language Label Description Also known as
English
MDM4 regulator of p53
mammalian protein found in Homo sapiens
  • MDM4
  • MDM4 protein variant G
  • p53-binding protein Mdm4
  • double minute 4, human homolog of; p53-binding protein
  • Mdm4 p53 binding protein homolog
  • Double minute 4 protein
  • protein Mdm4
  • MDM4 protein variant Y
  • MDM4-related protein 1
  • mdm2-like p53-binding protein
  • protein Mdmx
  • MDM4, p53 regulator

Statements

molecular function
protein binding
determination method or standard
IPI
27 references
retrieved
8 April 2019
stated in
Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein
GOA
curator
UniProt
UniProt protein ID
O15151
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151
determination method or standard
IPI
retrieved
8 April 2019
stated in
MDM2 and MDMX bind and stabilize the p53-related protein p73
GOA
curator
UniProt
UniProt protein ID
O15151
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151
determination method or standard
IPI
retrieved
8 April 2019
stated in
MDM4 binds ligands via a mechanism in which disordered regions become structured
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151
determination method or standard
IPI
retrieved
8 April 2019
stated in
Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151
determination method or standard
IPI
retrieved
8 April 2019
stated in
Adenoviral E1A targets Mdm4 to stabilize tumor suppressor p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151
determination method or standard
IPI
retrieved
8 April 2019
stated in
Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151
determination method or standard
IPI
retrieved
8 April 2019
stated in
Inactivation of the p53 pathway in retinoblastoma.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151
determination method or standard
IPI
retrieved
8 April 2019
stated in
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151
determination method or standard
IPI
retrieved
8 April 2019
stated in
14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151
determination method or standard
IPI
retrieved
8 April 2019
stated in
Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151
determination method or standard
IPI
retrieved
8 April 2019
stated in
An essential function of the extreme C-terminus of MDM2 can be provided by MDMX
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151
determination method or standard
IPI
retrieved
8 April 2019
stated in
Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 binding
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151
determination method or standard
IPI
retrieved
8 April 2019
stated in
Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151
determination method or standard
IPI
retrieved
8 April 2019
stated in
BIRC7–E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151
determination method or standard
IPI
retrieved
8 April 2019
stated in
DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151
determination method or standard
IPI
retrieved
8 April 2019
stated in
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151
determination method or standard
IPI
retrieved
8 April 2019
stated in
MDMX regulation of p53 response to ribosomal stress
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151
determination method or standard
IPI
retrieved
8 April 2019
stated in
JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151
determination method or standard
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151
determination method or standard
IPI
retrieved
8 April 2019
stated in
MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151
determination method or standard
IPI
retrieved
8 April 2019
stated in
Effects of MdmX on Mdm2-mediated downregulation of pRB
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151
determination method or standard
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151
determination method or standard
IPI
retrieved
8 April 2019
stated in
Turning the RING domain protein MdmX into an active ubiquitin-protein ligase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151
determination method or standard
IPI
retrieved
8 April 2019
stated in
The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151
determination method or standard
IPI
retrieved
8 April 2019
stated in
Pooled-matrix protein interaction screens using Barcode Fusion Genetics
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151
determination method or standard
IPI
biological process

Identifiers

PDB structure ID
 
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