Lysosomal-associated membrane protein 1 (Q21494692)

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mammalian protein found in Mus musculus

P2B
120 kDa lysosomal membrane glycoprotein
LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 1 PRECURSOR (LAMP-1) (LGP-A) (LGP-120) (CD107A) (P2B)
lysosome-associated membrane protein 1
LGP-A
lysosomal membrane glycoprotein A
Lamp1
LGP-120
lysosome-associated membrane glycoprotein 1
Lamp I
lysosomal membrane glycoprotein 1
CD107 antigen-like family member A

Language	Label	Description	Also known as
English	Lysosomal-associated membrane protein 1	mammalian protein found in Mus musculus	P2B 120 kDa lysosomal membrane glycoprotein LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 1 PRECURSOR (LAMP-1) (LGP-A) (LGP-120) (CD107A) (P2B) lysosome-associated membrane protein 1 LGP-A lysosomal membrane glycoprotein A Lamp1 LGP-120 lysosome-associated membrane glycoprotein 1 Lamp I lysosomal membrane glycoprotein 1 CD107 antigen-like family member A

Statements

1 reference

25 May 2022

UniProt protein ID

lysosome-associated membrane glycoprotein

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P11438

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Lysosome-associated membrane glycoprotein, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

protein domain specific binding

determination method or standard

1 reference

9 May 2019

The lysosomal polypeptide transporter TAPL is stabilized by interaction with LAMP-1 and LAMP-2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

protein binding

determination method or standard

1 reference

9 May 2019

Amelogenin, a major structural protein in mineralizing enamel, is also expressed in soft tissues: brain and cells of the hematopoietic system

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

lysosomal membrane

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

determination method or standard

1 reference

9 May 2019

Dysferlin Interacts with Annexins A1 and A2 and Mediates Sarcolemmal Wound-healing

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

integral component of membrane

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

cytolytic granule

determination method or standard

1 reference

9 May 2019

Impaired NK cytolytic activity and enhanced tumor growth in NK lytic-associated molecule-deficient mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

phagolysosome membrane

determination method or standard

1 reference

9 May 2019

HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

determination method or standard

1 reference

9 May 2019

Amelogenin, a major structural protein in mineralizing enamel, is also expressed in soft tissues: brain and cells of the hematopoietic system

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

determination method or standard

1 reference

9 May 2019

Rab27a regulates the peripheral distribution of melanosomes in melanocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

synaptic vesicle

determination method or standard

1 reference

9 May 2019

AP-3-dependent mechanisms control the targeting of a chloride channel (ClC-3) in neuronal and non-neuronal cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

determination method or standard

3 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

9 May 2019

Localization of the murine Niemann-Pick C1 protein to two distinct intracellular compartments

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

9 May 2019

Disruption of ClC-3, a chloride channel expressed on synaptic vesicles, leads to a loss of the hippocampus

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

determination method or standard

1 reference

9 May 2019

Localization of the murine Niemann-Pick C1 protein to two distinct intracellular compartments

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

external side of plasma membrane

determination method or standard

1 reference

9 May 2019

Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

phagocytic vesicle

determination method or standard

1 reference

9 May 2019

Salmonella acquires lysosome-associated membrane protein 1 (LAMP1) on phagosomes from Golgi via SipC protein-mediated recruitment of host Syntaxin6.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

determination method or standard

9 references

9 May 2019

Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

9 May 2019

Endoplasmic reticulum-associated degradation-induced dissociation of class II invariant chain complexes containing a glycosylation-deficient form of p41

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

9 May 2019

The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

9 May 2019

Small GTPase Rah/Rab34 is associated with membrane ruffles and macropinosomes and promotes macropinosome formation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

9 May 2019

Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

9 May 2019

Slc11a1, formerly Nramp1, is expressed in dendritic cells and influences major histocompatibility complex class II expression and antigen-presenting cell function

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

9 May 2019

Mammalian late vacuole protein sorting orthologues participate in early endosomal fusion and interact with the cytoskeleton

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

plasma membrane

determination method or standard

determination method or standard

23 references

9 May 2019

Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

9 May 2019

The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

9 May 2019

Role for phospholipid flippase complex of ATP8A1 and CDC50A proteins in cell migration

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

9 May 2019

The giant spectrin βV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

9 May 2019

Endoplasmic reticulum-associated degradation-induced dissociation of class II invariant chain complexes containing a glycosylation-deficient form of p41

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

9 May 2019

Sialin expression in the CNS implicates extralysosomal function in neurons

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

9 May 2019

Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

9 May 2019

The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

9 May 2019

Christianson syndrome protein NHE6 modulates TrkB endosomal signaling required for neuronal circuit development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

9 May 2019

CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

9 May 2019

Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

9 May 2019

Palmitoyl protein thioesterase 1 (PPT1) deficiency causes endocytic defects connected to abnormal saposin processing

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

9 May 2019

Impaired membrane resealing and autoimmune myositis in synaptotagmin VII-deficient mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

9 May 2019

Novel Role of TRPML2 in the Regulation of the Innate Immune Response

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

9 May 2019

Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

9 May 2019

Intact lysosome transport and phagosome function despite kinectin deficiency

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

9 May 2019

Emerging role for autophagy in the removal of aggresomes in Schwann cells.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

9 May 2019

Goofy coordinates the acuity of olfactory signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

9 May 2019

Dynamics of major histocompatibility complex class II compartments during B cell receptor-mediated cell activation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

9 May 2019

Localization of the murine Niemann-Pick C1 protein to two distinct intracellular compartments

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

9 May 2019

Accelerated antigen presentation and elicitation of humoral response in vivo by FcgammaRIIB- and FcgammaRI/III-mediated immune complex uptake

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

determination method or standard

1 reference

9 May 2019

In Vivo Evidence for Lysosome Depletion and Impaired Autophagic Clearance in Hereditary Spastic Paraplegia Type SPG11

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

determination method or standard

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

multivesicular body

determination method or standard

3 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

9 May 2019

Dynamics of major histocompatibility complex class II compartments during B cell receptor-mediated cell activation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

integral component of synaptic vesicle membrane

determination method or standard

1 reference

16 July 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11438&geneProductId=UniProtKB:P11438

determination method or standard

plasma membrane

determination method or standard

4 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

late endosome membrane

determination method or standard

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

biological process

spermatogenesis

determination method or standard

1 reference

9 May 2019

Comparative analysis of testis protein evolution in rodents

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

protein stabilization

determination method or standard

1 reference

9 May 2019

The lysosomal polypeptide transporter TAPL is stabilized by interaction with LAMP-1 and LAMP-2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

establishment of protein localization to organelle

determination method or standard

3 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11438

determination method or standard

lysosome-associated membrane glycoprotein, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P11438

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000033824

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000033824

Sitelinks

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Multilingual sites(0 entries)

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