Spastin (Q2308016)

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mammalian protein found in Homo sapiens
  • spastin
  • spastic paraplegia 4 (autosomal dominant; spastin)
  • spastic paraplegia 4 protein
  • SPAST
edit
Language Label Description Also known as
English
Spastin
mammalian protein found in Homo sapiens
  • spastin
  • spastic paraplegia 4 (autosomal dominant; spastin)
  • spastic paraplegia 4 protein
  • SPAST

Statements

molecular function
microtubule-severing ATPase activity
determination method or standard
IDA
IEA
7 references
retrieved
7 March 2017
stated in
GOA
curator
UniProt
UniProt protein ID
Q9UBP0
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0
determination method or standard
IEA
retrieved
7 March 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0
determination method or standard
IEA
retrieved
7 March 2017
stated in
Graded Control of Microtubule Severing by Tubulin Glutamylation
GOA
curator
UniProt
UniProt protein ID
Q9UBP0
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0
determination method or standard
IDA
retrieved
7 March 2017
stated in
Human spastin has multiple microtubule-related functions
GOA
curator
UniProt
UniProt protein ID
Q9UBP0
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0
determination method or standard
IDA
retrieved
7 March 2017
stated in
Linking axonal degeneration to microtubule remodeling by Spastin-mediated microtubule severing
GOA
curator
UniProt
UniProt protein ID
Q9UBP0
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0
determination method or standard
IDA
retrieved
7 March 2017
stated in
Recognition of C-terminal amino acids in tubulin by pore loops in Spastin is important for microtubule severing
GOA
curator
UniProt
UniProt protein ID
Q9UBP0
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0
determination method or standard
IDA
retrieved
7 March 2017
stated in
The nucleotide cycle of spastin correlates with its microtubule-binding properties
GOA
curator
UniProt
UniProt protein ID
Q9UBP0
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0
determination method or standard
IDA
protein binding
determination method or standard
IPI
7 references
retrieved
8 April 2019
stated in
SPG20 protein spartin is recruited to midbodies by ESCRT-III protein Ist1 and participates in cytokinesis
GOA
curator
UniProt
UniProt protein ID
Q9UBP0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0
determination method or standard
IPI
retrieved
8 April 2019
stated in
Interaction of two hereditary spastic paraplegia gene products, spastin and atlastin, suggests a common pathway for axonal maintenance
GOA
curator
UniProt
UniProt protein ID
Q9UBP0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0
determination method or standard
IPI
retrieved
8 April 2019
stated in
Protrudin binds atlastins and endoplasmic reticulum-shaping proteins and regulates network formation
GOA
curator
UniProt
UniProt protein ID
Q9UBP0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B
GOA
curator
UniProt
UniProt protein ID
Q9UBP0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0
determination method or standard
IPI
retrieved
8 April 2019
stated in
Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing
GOA
curator
UniProt
UniProt protein ID
Q9UBP0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0
determination method or standard
IPI
retrieved
8 April 2019
stated in
Hereditary spastic paraplegia proteins REEP1, spastin, and atlastin-1 coordinate microtubule interactions with the tubular ER network
GOA
curator
UniProt
UniProt protein ID
Q9UBP0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0
determination method or standard
IPI
retrieved
8 April 2019
stated in
Interaction of two hereditary spastic paraplegia gene products, spastin and atlastin, suggests a common pathway for axonal maintenance
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0
determination method or standard
IPI
microtubule-severing ATPase activity
determination method or standard
IBA
IDA
IEA
8 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9UBP0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0
determination method or standard
IEA
retrieved
8 April 2019
stated in
Graded Control of Microtubule Severing by Tubulin Glutamylation
GOA
curator
UniProt
UniProt protein ID
Q9UBP0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0
determination method or standard
IDA
retrieved
8 April 2019
stated in
Recognition of C-terminal amino acids in tubulin by pore loops in Spastin is important for microtubule severing
GOA
curator
UniProt
UniProt protein ID
Q9UBP0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0
determination method or standard
IDA
retrieved
8 April 2019
stated in
Linking axonal degeneration to microtubule remodeling by Spastin-mediated microtubule severing
GOA
curator
UniProt
UniProt protein ID
Q9UBP0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0
determination method or standard
IDA
retrieved
8 April 2019
stated in
Human spastin has multiple microtubule-related functions
GOA
curator
UniProt
UniProt protein ID
Q9UBP0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0
determination method or standard
IDA
retrieved
8 April 2019
stated in
The nucleotide cycle of spastin correlates with its microtubule-binding properties
GOA
curator
UniProt
UniProt protein ID
Q9UBP0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0
determination method or standard
IBA
cell component
biological process
microtubule severing
determination method or standard
IEA
IDA
IMP
7 references
retrieved
7 March 2017
stated in
Cortical constriction during abscission involves helices of ESCRT-III-dependent filaments
GOA
curator
UniProt
UniProt protein ID
Q9UBP0
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0
determination method or standard
IMP
retrieved
7 March 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0
determination method or standard
IEA
retrieved
7 March 2017
stated in
Graded Control of Microtubule Severing by Tubulin Glutamylation
GOA
curator
UniProt
UniProt protein ID
Q9UBP0
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0
determination method or standard
IDA
retrieved
7 March 2017
stated in
Human spastin has multiple microtubule-related functions
GOA
curator
UniProt
UniProt protein ID
Q9UBP0
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0
determination method or standard
IDA
retrieved
7 March 2017
stated in
Linking axonal degeneration to microtubule remodeling by Spastin-mediated microtubule severing
GOA
curator
UniProt
UniProt protein ID
Q9UBP0
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0
determination method or standard
IDA
retrieved
7 March 2017
stated in
Recognition of C-terminal amino acids in tubulin by pore loops in Spastin is important for microtubule severing
GOA
curator
UniProt
UniProt protein ID
Q9UBP0
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0
determination method or standard
IDA
retrieved
7 March 2017
stated in
The nucleotide cycle of spastin correlates with its microtubule-binding properties
GOA
curator
UniProt
UniProt protein ID
Q9UBP0
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0
determination method or standard
IDA
microtubule severing
determination method or standard
IDA
IEA
IMP
TAS
9 references
retrieved
8 April 2019
stated in
LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0
determination method or standard
TAS
retrieved
8 April 2019
stated in
Cortical constriction during abscission involves helices of ESCRT-III-dependent filaments
GOA
curator
UniProt
UniProt protein ID
Q9UBP0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0
determination method or standard
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9UBP0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0
determination method or standard
IEA
retrieved
8 April 2019
stated in
Graded Control of Microtubule Severing by Tubulin Glutamylation
GOA
curator
UniProt
UniProt protein ID
Q9UBP0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0
determination method or standard
IDA
retrieved
8 April 2019
stated in
Recognition of C-terminal amino acids in tubulin by pore loops in Spastin is important for microtubule severing
GOA
curator
UniProt
UniProt protein ID
Q9UBP0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0
determination method or standard
IDA
retrieved
8 April 2019
stated in
Linking axonal degeneration to microtubule remodeling by Spastin-mediated microtubule severing
GOA
curator
UniProt
UniProt protein ID
Q9UBP0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0
determination method or standard
IDA
retrieved
8 April 2019
stated in
Human spastin has multiple microtubule-related functions
GOA
curator
UniProt
UniProt protein ID
Q9UBP0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0
determination method or standard
IDA
retrieved
8 April 2019
stated in
The nucleotide cycle of spastin correlates with its microtubule-binding properties
GOA
curator
UniProt
UniProt protein ID
Q9UBP0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0
determination method or standard
IDA
Gene Atlas image
PBB GE SPAST 207724 s at fs.png
732 × 530; 12 KB
0 references

Identifiers

Ensembl protein ID
Freebase ID
/m/03cv6lg
0 references
 
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