NS3 protein of Hepatitis C virus associates with the tumour suppressor p53 and inhibits its function in an NS3 sequence-dependent manner (Q24337056)

1

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Motoko Nagano-Fujii

2

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Motofumi Tanaka

3

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Yuki Nomura-Takigawa

4

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Masanori Ikeda

5

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Nobuyuki Kato

6

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Hak Hotta

Journal of General Virology

8

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language of work or name

English

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publication date

June 2006

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published in

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volume

87

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issue

Pt 6

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page(s)

1703-13

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cites work

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Wild-type, but not mutant-type, p53 enhances nuclear accumulation of the NS3 protein of hepatitis C virus

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Hepatitis C virus nonstructural proteins are localized in a modified endoplasmic reticulum of cells expressing viral subgenomic replicons

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Subcellular localization of hepatitis C viral proteins in mammalian cells

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Efficient replication of a full-length hepatitis C virus genome, strain O, in cell culture, and development of a luciferase reporter system.

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Single-point mutations of hepatitis C virus NS3 that impair p53 interaction and anti-apoptotic activity of NS3.

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Cooperative binding of tetrameric p53 to DNA.

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Complex formation of the nonstructural protein 3 of hepatitis C virus with the p53 tumor suppressor

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p53, the cellular gatekeeper for growth and division

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Hepatitis C virus NS5A protein binds TBP and p53, inhibiting their DNA binding and p53 interactions with TBP and ERCC3

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Inhibition of protein synthesis by the nonstructural proteins NS4A and NS4B of hepatitis C virus

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Human papillomavirus immortalization and transformation functions

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Product review. New mammalian expression vectors

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ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

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HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis

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Modulation of p53 transcription regulatory activity and post-translational modification by hepatitis C virus core protein

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Hepatitis C viral proteins interact with Smad3 and differentially regulate TGF-beta/Smad3-mediated transcriptional activation

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Cell transformation induced by hepatitis C virus NS3 serine protease

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Liver p53 expression in patients with HCV-related chronic hepatitis.

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Post-translational modifications and activation of p53 by genotoxic stresses

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Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling

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Proteins of the S100 family regulate the oligomerization of p53 tumor suppressor

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Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase

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Hepatitis C virus infection is associated with the development of hepatocellular carcinoma

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Identification of an additional negative regulatory region for p53 sequence-specific DNA binding

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How p53 binds DNA as a tetramer

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p53-dependent transcriptional repression of p21(waf1) by hepatitis C virus NS3.

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Hepatitis C virus NS5A protein interacts with 2',5'-oligoadenylate synthetase and inhibits antiviral activity of IFN in an IFN sensitivity-determining region-independent manner

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Hepatitis C virus NS3 protein interacts with ELKS-{delta} and ELKS-{alpha}, members of a novel protein family involved in intracellular transport and secretory pathways

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Correlation between secondary structure of an amino-terminal portion of the nonstructural protein 3 (NS3) of hepatitis C virus and development of hepatocellular carcinoma

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7 January 2021

Nonstructural proteins 4A and 4B of hepatitis C virus transactivate the interleukin 8 promoter

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7 January 2021

Regulation of Interferon Regulatory Factor-3 by the Hepatitis C Virus Serine Protease

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7 January 2021

Identification of Hepatitis C Virus (HCV) Subtype 1b Strains That Are Highly, or Only Weakly, Associated with Hepatocellular Carcinoma on the Basis of the Secondary Structure of an Amino-Terminal Portion of the HCV NS3 Protein

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7 January 2021

Hepatitis C virus NS3 serine proteinase: trans-cleavage requirements and processing kinetics

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7 January 2021

Nuclear localization of the NS3 protein of hepatitis C virus and factors affecting the localization

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https://api.crossref.org/works/10.1099%2FVIR.0.81735-0

7 January 2021

Mutations in Hepatitis C Virus RNAs Conferring Cell Culture Adaptation

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https://api.crossref.org/works/10.1099%2FVIR.0.81735-0

7 January 2021

Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon

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https://api.crossref.org/works/10.1099%2FVIR.0.81735-0

7 January 2021

New insights into the mechanism of inhibition of p53 by simian virus 40 large T antigen

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7 January 2021

Pathogenesis of human papillomaviruses in differentiating epithelia

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7 January 2021

Identifiers

DOI

10.1099/VIR.0.81735-0

1 reference

Consolidated OpenCitations Corpus – April 2017

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Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

16690937

1 reference

Consolidated OpenCitations Corpus – April 2017