The ancient drug salicylate directly activates AMP-activated protein kinase (Q24630758)

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29 January 2020

title

The ancient drug salicylate directly activates AMP-activated protein kinase (English)

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29 January 2020

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ChEBI release 2020-05-28

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14

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Kirsty J Mustard

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Simon A Hawley

1

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Morgan D Fullerton

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Fiona A Ross

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Jonathan D Schertzer

4

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Cyrille Chevtzoff

5

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Katherine J Walker

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Mark W Peggie

7

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Darya Zibrova

8

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Kevin A Green

9

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Bruce E Kemp

11

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Kei Sakamoto

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Gregory R Steinberg

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language of work or name

English

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publication date

19 April 2012

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29 January 2020

1 reference

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29 January 2020

volume

336

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29 January 2020

issue

6083

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29 January 2020

page(s)

918-922

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Structure of mammalian AMPK and its regulation by ADP

29 January 2020

cites work

1 reference

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Role of AMP-activated protein kinase in mechanism of metformin action

7 April 2017

1 reference

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Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases

7 April 2017

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Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes

7 April 2017

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Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

7 April 2017

1 reference

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Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2

7 April 2017

1 reference

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Concentration-response relationships for salicylate-induced ototoxicity in normal volunteers

7 April 2017

1 reference

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AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

7 April 2017

1 reference

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Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials

7 April 2017

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β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK)

27 September 2017

1 reference

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Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation

27 September 2017

1 reference

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The effects of salsalate on glycemic control in patients with type 2 diabetes: a randomized trial

27 September 2017

1 reference

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AMPK beta1 deletion reduces appetite, preventing obesity and hepatic insulin resistance

27 September 2017

1 reference

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A cohort study of the risk of cancer associated with type 2 diabetes

27 September 2017

1 reference

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AMPK in Health and Disease

27 September 2017

1 reference

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Salsalate improves glycemia and inflammatory parameters in obese young adults

27 September 2017

1 reference

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Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.

27 September 2017

1 reference

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Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3399766

Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome

27 September 2017

1 reference

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Salicylates and sulfasalazine, but not glucocorticoids, inhibit leukocyte accumulation by an adenosine-dependent mechanism that is independent of inhibition of prostaglandin synthesis and p105 of NFkappaB.

27 September 2017

1 reference

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Jasmonate and salicylate as global signals for defense gene expression

27 September 2017

1 reference

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Eicosanoids in inflammation

27 September 2017

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Clinical significance of esterases in man.

27 September 2017

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Pharmacokinetics of aspirin and salicylate in relation to inhibition of arachidonate cyclooxygenase and antiinflammatory activity

27 September 2017

1 reference

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5'-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2C alpha and native bovine protein phosphatase-2AC.

27 September 2017

1 reference

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AMPK is a direct adenylate charge-regulated protein kinase.

30 May 2018

1 reference

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Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes.

28 November 2018

1 reference

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Dissecting the role of 5'-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase

28 November 2018

1 reference

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Action of sodium salicylate and related compounds on tissue metabolism in vitro

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22517326

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

5'-AMP activates the AMP-activated protein kinase cascade, and Ca2+/calmodulin activates the calmodulin-dependent protein kinase I cascade, via three independent mechanisms

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22517326

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCIENCE.1215327

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22517326%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

ADS bibcode

2012Sci...336..918H

0 references

1 reference

2 references

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29 January 2020

PubMed publication ID

22517326

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22517326%20AND%20SRC:MED&resulttype=core&format=json