Role of HIPK2 in kidney fibrosis (Q26796620)

1

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Niansong Wang

2

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Peter Chuang

3

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John C He

Kidney International Supplements

4

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publication date

November 2014

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published in

1 reference

Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1

PubMed

volume

4

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issue

1

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page(s)

97-101

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cites work

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Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival

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WIP1, a homeostatic regulator of the DNA damage response, is targeted by HIPK2 for phosphorylation and degradation

7 April 2017

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Tumor Protein 53-Induced Nuclear Protein 1 Enhances p53 Function and Represses Tumorigenesis

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Molecular targets for treatment of kidney fibrosis

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A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma

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Homeodomain interacting protein kinase 2 regulates postnatal development of enteric dopaminergic neurons and glia via BMP signaling

28 September 2017

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Hipk2 cooperates with p53 to suppress γ-ray radiation-induced mouse thymic lymphoma

28 September 2017

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The loss of the p53 activator HIPK2 is responsible for galectin-3 overexpression in well differentiated thyroid carcinomas

28 September 2017

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Phosphorylation of TCF proteins by homeodomain-interacting protein kinase 2.

28 September 2017

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Unfolded p53 in the pathogenesis of Alzheimer's disease: is HIPK2 the link?

28 September 2017

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Counteracting MDM2-induced HIPK2 downregulation restores HIPK2/p53 apoptotic signaling in cancer cells

28 September 2017

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Regulation of p53 activity by HIPK2: molecular mechanisms and therapeutical implications in human cancer cells.

28 September 2017

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Homeodomain interacting protein kinase 2: a target for Alzheimer's beta amyloid leading to misfolded p53 and inappropriate cell survival

28 September 2017

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Nox1 is involved in p53 deacetylation and suppression of its transcriptional activity and apoptosis.

28 September 2017

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Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling - roles of p53, p73 and HIPK2.

28 September 2017

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Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR.

28 September 2017

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Requirement of HDAC6 for transforming growth factor-beta1-induced epithelial-mesenchymal transition.

28 September 2017

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A collective form of cell death requires homeodomain interacting protein kinase

28 September 2017

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HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis

28 September 2017

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Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets

28 September 2017

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Mutations of the HIPK2 gene in acute myeloid leukemia and myelodysplastic syndrome impair AML1- and p53-mediated transcription

28 September 2017

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High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2.

28 September 2017

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HIPK2: a versatile switchboard regulating the transcription machinery and cell death

28 September 2017

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Regulation of homeodomain-interacting protein kinase 2 (HIPK2) effector function through dynamic small ubiquitin-related modifier-1 (SUMO-1) modification

28 September 2017

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Covalent modification of human homeodomain interacting protein kinase 2 by SUMO-1 at lysine 25 affects its stability.

28 September 2017

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Post-translational modification of p53 in tumorigenesis

28 September 2017

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Homeodomain-interacting protein kinase-2 regulates apoptosis in developing sensory and sympathetic neurons

28 September 2017

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Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosis

28 September 2017

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Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP.

28 September 2017

1 reference

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Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

28 September 2017

1 reference

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A systems approach identifies HIPK2 as a key regulator of kidney fibrosis

28 September 2017

1 reference

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Autoregulatory control of the p53 response by caspase-mediated processing of HIPK2.

31 May 2018

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Tumor suppressor protein Pdcd4 interacts with Daxx and modulates the stability of Daxx and the Hipk2-dependent phosphorylation of p53 at serine 46.

31 May 2018

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SIAH-mediated ubiquitination and degradation of acetyl-transferases regulate the p53 response and protein acetylation.

28 November 2018

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A redox-regulated SUMO/acetylation switch of HIPK2 controls the survival threshold to oxidative stress.

28 November 2018

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Control of nuclear HIPK2 localization and function by a SUMO interaction motif.

28 November 2018

1 reference

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Homeodomain-interacting protein kinases (Hipks) promote Wnt/Wg signaling through stabilization of beta-catenin/Arm and stimulation of target gene expression

28 November 2018

1 reference

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Hipk is an essential protein that promotes Notch signal transduction in the Drosophila eye by inhibition of the global co-repressor Groucho

28 November 2018

1 reference

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Small ubiquitin-related modifier (SUMO) binding determines substrate recognition and paralog-selective SUMO modification

28 November 2018

1 reference

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MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis.

28 November 2018

1 reference

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Homeodomain-interacting protein kinase 2 is the ionizing radiation-activated p53 serine 46 kinase and is regulated by ATM.

28 November 2018

1 reference

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