The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity (Q26824764)

Elitsa Ivanova

2

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Caroline Lambrecht

3

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Dorien Haesen

4

1 reference

Veerle Janssens

5

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language of work or name

1 reference

January 2013

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280

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PubMed

issue

2

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PubMed

page(s)

644-61

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Global, in vivo, and site-specific phosphorylation dynamics in signaling networks

PubMed

cites work

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Emerging roles of nuclear protein phosphatases

21 January 2018

1 reference

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From promiscuity to precision: protein phosphatases get a makeover

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

PP2A holoenzyme assembly: in cauda venenum (the sting is in the tail).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Separation of PP2A core enzyme and holoenzyme with monoclonal antibodies against the regulatory A subunit: abundant expression of both forms in cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Calpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Generation of Ppp2Ca and Ppp2Cb conditional null alleles in mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Human Cancer-Associated Mutations in the Aα Subunit of Protein Phosphatase 2A Increase Lung Cancer Incidence in Aα Knock-In and Knockout Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

The tumor suppressor PP2A Abeta regulates the RalA GTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

A developmentally regulated, neuron-specific splice variant of the variable subunit Bbeta targets protein phosphatase 2A to mitochondria and modulates apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Diversity in genomic organisation, developmental regulation and distribution of the murine PR72/B" subunits of protein phosphatase 2A

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

The 48-kDa alternative translation isoform of PP2A:B56epsilon is required for Wnt signaling during midbrain-hindbrain boundary formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Localization of Saccharomyces cerevisiae protein phosphatase 2A subunits throughout mitotic cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Serine/threonine phosphatases: mechanism through structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Determinants for Substrate Specificity of Protein Phosphatase 2A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Structure of the protein phosphatase 2A holoenzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Structure of a Protein Phosphatase 2A Holoenzyme: Insights into B55-Mediated Tau Dephosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Structure and function of the PP2A-shugoshin interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Genomic organisation, chromosomal localisation tissue distribution and developmental regulation of the PR61/B' regulatory subunits of protein phosphatase 2A in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Diversity in the regulatory B-subunits of protein phosphatase 2A: identification of a novel isoform highly expressed in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Cloning and characterization of B delta, a novel regulatory subunit of protein phosphatase 2A

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Diversity, developmental regulation and distribution of murine PR55/B subunits of protein phosphatase 2A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Phosphatases: providing safe passage through mitotic exit

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Protein phosphatases and the regulation of mitosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

The role and therapeutic potential of Ser/Thr phosphatase PP2A in apoptotic signalling networks in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Animal models reveal role for tau phosphorylation in human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Functions of B56-containing PP2As in major developmental and cancer signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Beyond the dopamine receptor: regulation and roles of serine/threonine protein phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

PP2A: the expected tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Involvement of PP2A in viral and cellular transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

A tumor suppressor role for PP2A-B56alpha through negative regulation of c-Myc and other key oncoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Multiple pathways regulated by the tumor suppressor PP2A in transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Protein phosphatase 2A PR130/B''alpha1 subunit binds to the SH2 domain-containing inositol polyphosphate 5-phosphatase 2 and prevents epidermal growth factor (EGF)-induced EGF receptor degradation sustaining EGF-mediated signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

PP1 and PP2A phosphatases--cooperating partners in modulating retinoblastoma protein activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Protein phosphatase 2A is targeted to cell division control protein 6 by a calcium-binding regulatory subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Mice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Generation of active protein phosphatase 2A is coupled to holoenzyme assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

A novel and essential mechanism determining specificity and activity of protein phosphatase 2A (PP2A) in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

B56-associated protein phosphatase 2A is required for survival and protects from apoptosis in Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Critical role for protein phosphatase 2A heterotrimers in mammalian cell survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Leucine carboxyl methyltransferase-1 is necessary for normal progression through mitosis in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Targeted disruption of the PME-1 gene causes loss of demethylated PP2A and perinatal lethality in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Identification of PP2A complexes and pathways involved in cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Structure of protein phosphatase methyltransferase 1 (PPM1), a leucine carboxyl methyltransferase involved in the regulation of protein phosphatase 2A activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

The structure of human leucine carboxyl methyltransferase 1 that regulates protein phosphatase PP2A

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

The structural basis for tight control of PP2A methylation and function by LCMT-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Methylation of the C-terminal leucine residue of the PP2A catalytic subunit is unnecessary for the catalytic activity and the binding of regulatory subunit (PR55/B).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Protein phosphatase 2A methylation: a link between elevated plasma homocysteine and Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Folate deficiency induces in vitro and mouse brain region-specific downregulation of leucine carboxyl methyltransferase-1 and protein phosphatase 2A B(alpha) subunit expression that correlate with enhanced tau phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

The metabolic advantage of tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

An inactive protein phosphatase 2A population is associated with methylesterase and can be re-activated by the phosphotyrosyl phosphatase activator

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Structural mechanism of demethylation and inactivation of protein phosphatase 2A

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Spatial control of protein phosphatase 2A (de)methylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Quantitative interaction proteomics using mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

The protein phosphatase 2A phosphatase activator is a novel peptidyl-prolyl cis/trans-isomerase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Structure and mechanism of the phosphotyrosyl phosphatase activator

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

The phosphotyrosyl phosphatase activator of protein phosphatase 2A. A novel purification method, immunological and enzymic characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Functional analysis of RRD1 (YIL153w) and RRD2 (YPL152w), which encode two putative activators of the phosphotyrosyl phosphatase activity of PP2A in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

The Saccharomyces cerevisiae homologue YPA1 of the mammalian phosphotyrosyl phosphatase activator of protein phosphatase 2A controls progression through the G1 phase of the yeast cell cycle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

The phosphotyrosyl phosphatase activator, Ncs1p (Rrd1p), functions with Cla4p to regulate the G(2)/M transition in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

A yeast homologue of the human phosphotyrosyl phosphatase activator PTPA is implicated in protection against oxidative DNA damage induced by the model carcinogen 4-nitroquinoline 1-oxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

De novo telomere formation is suppressed by the Mec1-dependent inhibition of Cdc13 accumulation at DNA breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

The Saccharomyces cerevisiae phosphotyrosyl phosphatase activator proteins are required for a subset of the functions disrupted by protein phosphatase 2A mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

The Saccharomyces cerevisiae phosphatase activator RRD1 is required to modulate gene expression in response to rapamycin exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Rrd1 isomerizes RNA polymerase II in response to rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

The peptidyl prolyl isomerase Rrd1 regulates the elongation of RNA polymerase II during transcriptional stresses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

The yeast phosphotyrosyl phosphatase activator protein, yPtpa1/Rrd1, interacts with Sit4 phosphatase to mediate resistance to 4-nitroquinoline-1-oxide and UVA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Specific interactions of PP2A and PP2A-like phosphatases with the yeast PTPA homologues, Ypa1 and Ypa2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

The yeast phosphotyrosyl phosphatase activator is part of the Tap42-phosphatase complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Autoregulation of protein phosphatase type 2A expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Protein phosphatase 2A suppresses MAP kinase signalling and ectopic protein expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

The scaffolding A/Tpd3 subunit and high phosphatase activity are dispensable for Cdc55 function in the Saccharomyces cerevisiae spindle checkpoint and in cytokinesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Global analysis of protein expression in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

B cell receptor-associated protein α4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Interaction with Tap42 Is Required for the Essential Function of Sit4 and Type 2A Phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Overlapping binding sites in protein phosphatase 2A for association with regulatory A and alpha-4 (mTap42) subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Low resolution structure of the human alpha4 protein (IgBP1) and studies on the stability of alpha4 and of its yeast ortholog Tap42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

The structure of Tap42/alpha4 reveals a tetratricopeptide repeat-like fold and provides insights into PP2A regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

The E3 Ubiquitin Ligase- and Protein Phosphatase 2A (PP2A)-binding Domains of the Alpha4 Protein Are Both Required for Alpha4 to Inhibit PP2A Degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Carboxyl methylation of the phosphoprotein phosphatase 2A catalytic subunit promotes its functional association with regulatory subunits in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

The alpha4-containing form of protein phosphatase 2A in liver and hepatic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Alpha4 protein as a common regulator of type 2A-related serine/threonine protein phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Alpha 4 associates with protein phosphatases 2A, 4, and 6

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Rapamycin activates Tap42-associated phosphatases by abrogating their association with Tor complex 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Regulation of protein phosphatase 2A catalytic activity by alpha4 protein and its yeast homolog Tap42

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Parallel purification of three catalytic subunits of the protein serine/threonine phosphatase 2A family (PP2A(C), PP4(C), and PP6(C)) and analysis of the interaction of PP2A(C) with alpha4 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Interaction analysis of the heterotrimer formed by the phosphatase 2A catalytic subunit, alpha4 and the mammalian ortholog of yeast Tip41 (TIPRL).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Overexpression of the mTOR alpha4 phosphoprotein activates protein phosphatase 2A and increases Stat1alpha binding to PIAS1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

The heterodimer of alpha4 and PP2Ac is associated with S6 kinase1 in B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

The PP2A-associated protein alpha4 is an essential inhibitor of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Alpha4 is an essential regulator of PP2A phosphatase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Microcystin-LR (MCLR) induces a compensation of PP2A activity mediated by α4 protein in HEK293 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

The alpha4 regulatory subunit exerts opposing allosteric effects on protein phosphatases PP6 and PP2A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Cytokine activation of p38 mitogen-activated protein kinase and apoptosis is opposed by alpha-4 targeting of protein phosphatase 2A for site-specific dephosphorylation of MEK3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit alpha 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

MID1, mutated in Opitz syndrome, encodes an ubiquitin ligase that targets phosphatase 2A for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Alpha4 is a ubiquitin-binding protein that regulates protein serine/threonine phosphatase 2A ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Active transport of the ubiquitin ligase MID1 along the microtubules is regulated by protein phosphatase 2A

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

The MID1/PP2A complex: a key to the pathogenesis of Opitz BBB/G syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

alpha4 phosphoprotein interacts with EDD E3 ubiquitin ligase and poly(A)-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

BCR signal through alpha 4 is involved in S6 kinase activation and required for B cell maturation including isotype switching and V region somatic hypermutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

T cell-specific gene targeting reveals that alpha4 is required for early T cell development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

The PP2A-associated protein alpha4 plays a critical role in the regulation of cell spreading and migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Detection and Characterization of the In Vitro E3 Ligase Activity of the Human MID1 Protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Control of mTORC1 signaling by the Opitz syndrome protein MID1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

α4 is highly expressed in carcinogen-transformed human cells and primary human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Identification of a PP2A-interacting protein that functions as a negative regulator of phosphatase activity in the ATM/ATR signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

An integrated workflow for charting the human interaction proteome: insights into the PP2A system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Purification and identification of a novel subunit of protein serine/threonine phosphatase 4

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

A novel 50 kDa protein forms complexes with protein phosphatase 4 and is located at centrosomal microtubule organizing centres

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Large-scale mapping of human protein-protein interactions by mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Carboxymethylation of nuclear protein serine/threonine phosphatase X

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Discovery and Optimization of Sulfonyl Acrylonitriles as Selective, Covalent Inhibitors of Protein Phosphatase Methylesterase-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

Crystal structure of the PP2A phosphatase activator: implications for its PP2A-specific PPIase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

inferred from DOI database lookup

7 January 2021

based on heuristic

Selection of Protein Phosphatase 2A Regulatory Subunits Is Mediated by the C Terminus of the Catalytic Subunit

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X

inferred from DOI database lookup

7 January 2021

based on heuristic

Overexpression of immunoglobulin (CD79a) binding protein1 (IGBP‐1) in small lung adenocarcinomas and its clinicopathological significance

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2012.08579.X