Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H(+) symporters (Q28081811)

language of work or name

1 reference

February 2016

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Journal of Molecular Medicine

1 February 2016

12 references

14 March 2019

3 April 2019

25 June 2019

7 October 2019

28 November 2019

15 December 2019

14 September 2020

13 November 2020

8 February 2021

1 July 2021

5 July 2021

27 January 2024

13 references

14 March 2019

3 April 2019

25 June 2019

7 October 2019

28 November 2019

15 December 2019

14 September 2020

13 November 2020

8 February 2021

1 July 2021

5 July 2021

27 January 2024

94

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issue

2

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page(s)

155-71

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Creative Commons Attribution 4.0 International

copyright license

12 references

14 March 2019

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25 June 2019

7 October 2019

28 November 2019

15 December 2019

14 September 2020

13 November 2020

8 February 2021

1 July 2021

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27 January 2024

copyright status

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A novel form of the membrane protein CD147 that contains an extra Ig-like domain and interacts homophilically

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Substrate-induced regulation of the human colonic monocarboxylate transporter, MCT1

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Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle

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CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression

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Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle

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Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70)

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Basigin (CD147): a multifunctional transmembrane protein involved in reproduction, neural function, inflammation and tumor invasion

20 March 2017

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Loss of MCT1, MCT3, and MCT4 expression in the retinal pigment epithelium and neural retina of the 5A11/basigin-null mouse

20 March 2017

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Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

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Energy metabolism in tumor cells

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Metabolic remodeling of malignant gliomas for enhanced sensitization during radiotherapy: an in vitro study

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HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

20 March 2017

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HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

20 March 2017

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AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10

20 March 2017

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Studies on the DIDS-binding site of monocarboxylate transporter 1 suggest a homology model of the open conformation and a plausible translocation cycle

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MCT1 and its accessory protein CD147 are differentially regulated by TSH in rat thyroid cells

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Fluorescence resonance energy transfer studies on the interaction between the lactate transporter MCT1 and CD147 provide information on the topology and stoichiometry of the complex in situ

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20 March 2017

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7 April 2017

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7 April 2017

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Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

7 April 2017

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Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

7 April 2017

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7 April 2017

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Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

7 April 2017

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Knock out of the BASIGIN/CD147 chaperone of lactate/H+ symporters disproves its pro-tumour action via extracellular matrix metalloproteases (MMPs) induction

24 May 2017

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Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status

29 September 2017

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A lactate-induced response to hypoxia.

29 September 2017

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EMMPRIN/CD147 is a novel coreceptor of VEGFR-2 mediating its activation by VEGF.

29 September 2017

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The Na(+)/HCO3(-) Co-Transporter SLC4A4 Plays a Role in Growth and Migration of Colon and Breast Cancer Cells

29 September 2017

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Identification of key binding site residues of MCT1 for AR-C155858 reveals the molecular basis of its isoform selectivity

29 September 2017

1 reference

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Inhibition of monocarboxylate transporter-1 (MCT1) by AZD3965 enhances radiosensitivity by reducing lactate transport

29 September 2017

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Functional polarization of tumour-associated macrophages by tumour-derived lactic acid.

29 September 2017

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Blocking lactate export by inhibiting the Myc target MCT1 Disables glycolysis and glutathione synthesis.

29 September 2017

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Activity of the monocarboxylate transporter 1 inhibitor AZD3965 in small cell lung cancer

29 September 2017

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29 September 2017

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The neuroplastin adhesion molecules are accessory proteins that chaperone the monocarboxylate transporter MCT2 to the neuronal cell surface

29 September 2017

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Differential sensitivities to lactate transport inhibitors of breast cancer cell lines.

29 September 2017

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CD147 regulates the expression of MCT1 and lactate export in multiple myeloma cells

29 September 2017

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Disrupting proton dynamics and energy metabolism for cancer therapy

29 September 2017

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Antagonistic effects of anti-EMMPRIN antibody when combined with chemotherapy against hypovascular pancreatic cancers.

29 September 2017

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Tumor-derived lactate modifies antitumor immune response: effect on myeloid-derived suppressor cells and NK cells

29 September 2017

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Carbonic anhydrase IX from cancer-associated fibroblasts drives epithelial-mesenchymal transition in prostate carcinoma cells

29 September 2017

1 reference

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Cancer metabolism, stemness and tumor recurrence: MCT1 and MCT4 are functional biomarkers of metabolic symbiosis in head and neck cancer

29 September 2017

1 reference

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Metabolic reprogramming and validation of hyperpolarized 13C lactate as a prostate cancer biomarker using a human prostate tissue slice culture bioreactor

29 September 2017

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In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation

29 September 2017

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Lactate dehydrogenase-B is silenced by promoter methylation in a high frequency of human breast cancers

29 September 2017

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Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer

29 September 2017

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Control of glutamine metabolism by the tumor suppressor Rb.

29 September 2017

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Oxygen-independent regulation of HIF-1: novel involvement of PI3K/AKT/mTOR pathway in cancer

29 September 2017

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The pentose phosphate pathway: an antioxidant defense and a crossroad in tumor cell fate

29 September 2017

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Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism

29 September 2017

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Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis.

29 September 2017

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Tumor metabolism as modulator of immune response and tumor progression

29 September 2017

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Role of monocarboxylate transporters in human cancers: state of the art.

29 September 2017

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Using the "reverse Warburg effect" to identify high-risk breast cancer patients: stromal MCT4 predicts poor clinical outcome in triple-negative breast cancers

29 September 2017

1 reference

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Regulation of monocarboxylate transporter MCT1 expression by p53 mediates inward and outward lactate fluxes in tumors.

29 September 2017

1 reference

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The monocarboxylate transporter family--role and regulation

29 September 2017

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The monocarboxylate transporter family--Structure and functional characterization

29 September 2017

1 reference

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Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

29 September 2017

1 reference

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Lactate: a metabolic key player in cancer

29 September 2017

1 reference

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Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effect

29 September 2017

1 reference

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CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors

29 September 2017

1 reference

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Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth

29 September 2017

1 reference

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miR-29a and miR-29b contribute to pancreatic beta-cell-specific silencing of monocarboxylate transporter 1 (Mct1)

29 September 2017

1 reference

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Lactate MRSI and DCE MRI as surrogate markers of prostate tumor aggressiveness

29 September 2017

1 reference

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Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release

29 September 2017

1 reference

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Metabolic markers in relation to hypoxia; staining patterns and colocalization of pimonidazole, HIF-1α, CAIX, LDH-5, GLUT-1, MCT1 and MCT4

29 September 2017

1 reference

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Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts

29 September 2017

1 reference

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Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis

29 September 2017

1 reference

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Choosing between glycolysis and oxidative phosphorylation: A tumor's dilemma?

29 September 2017

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Targeting mitochondrial glutaminase activity inhibits oncogenic transformation

29 September 2017

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Anti-EMMPRIN antibody treatment of head and neck squamous cell carcinoma in an ex-vivo model

29 September 2017

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Glutamine addiction: a new therapeutic target in cancer

29 September 2017

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Cancer-related issues of CD147.

29 September 2017

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Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program

29 September 2017

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Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Hyperpolarized 13C magnetic resonance metabolic imaging: application to brain tumors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Glycolytic metabolism and tumour response to fractionated irradiation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Lactic acid and acidification inhibit TNF secretion and glycolysis of human monocytes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Co-localisation of hypoxia and perfusion markers with parameters of glucose metabolism in human squamous cell carcinoma (hSCC) xenografts.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

MYC-induced cancer cell energy metabolism and therapeutic opportunities

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

The interaction of HAb18G/CD147 with integrin alpha6beta1 and its implications for the invasion potential of human hepatoma cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Glutamine homeostasis and mitochondrial dynamics

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Anti-EMMPRIN monoclonal antibody as a novel agent for therapy of head and neck cancer.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Hyaluronan, CD44, and emmprin regulate lactate efflux and membrane localization of monocarboxylate transporters in human breast carcinoma cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Interaction of monocarboxylate transporter 4 with beta1-integrin and its role in cell migration

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

The genomic analysis of lactic acidosis and acidosis response in human cancers

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Lactate promotes glioma migration by TGF-beta2-dependent regulation of matrix metalloproteinase-2.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Evaluation of MR markers that predict survival in patients with newly diagnosed GBM prior to adjuvant therapy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Overexpression of HAb18G/CD147 promotes invasion and metastasis via alpha3beta1 integrin mediated FAK-paxillin and FAK-PI3K-Ca2+ pathways

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Blocking CD147 induces cell death in cancer cells through impairment of glycolytic energy metabolism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Hyaluronan, CD44 and Emmprin: partners in cancer cell chemoresistance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Basigin-2 is a cell surface receptor for soluble basigin ligand.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Lactate, with oxygen, incites angiogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Epithelial and mesenchymal tumor compartments exhibit in vivo complementary patterns of vascular perfusion and glucose metabolism.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

The specific monocarboxylate transporter-1 (MCT-1) inhibitor, AR-C117977, induces donor-specific suppression, reducing acute and chronic allograft rejection in the rat.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Up-regulation of CD147 and matrix metalloproteinase-2, -9 induced by P-glycoprotein substrates in multidrug resistant breast cancer cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Monocarboxylate transporter 4 regulates maturation and trafficking of CD147 to the plasma membrane in the metastatic breast cancer cell line MDA-MB-231.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

p53: new roles in metabolism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Lactate sensitive transcription factor network in L6 cells: activation of MCT1 and mitochondrial biogenesis.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Multiple mechanisms underlie defective recognition of melanoma cells cultured in three-dimensional architectures by antigen-specific cytotoxic T lymphocytes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Hypoxia-inducible factor (HIF) in human tumorigenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

A small interfering CD147-targeting RNA inhibited the proliferation, invasiveness, and metastatic activity of malignant melanoma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Cancer's molecular sweet tooth and the Warburg effect.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Inhibition of CD147 gene expression via RNA interference reduces tumor cell invasion, tumorigenicity and increases chemosensitivity to paclitaxel in HO-8910pm cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Hypoxia signalling in cancer and approaches to enforce tumour regression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

High incidence of EMMPRIN expression in human tumors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Inhibition of CD147 expression reduces tumor cell invasion in human prostate cancer cell line via RNA interference

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Tumor-derived lactic acid modulates dendritic cell activation and antigen expression.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Lactate in solid malignant tumors: potential basis of a metabolic classification in clinical oncology

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Lactate: mirror and motor of tumor malignancy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Emmprin promotes anchorage-independent growth in human mammary carcinoma cells by stimulating hyaluronan production

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Retina-specific expression of 5A11/Basigin-2, a member of the immunoglobulin gene superfamily.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Contribution by different fuels and metabolic pathways to the total ATP turnover of proliferating MCF-7 breast cancer cells.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Lactate stimulates fibroblast expression of hyaluronan and CD44: the Warburg effect revisited

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Positron emission tomography scanning: current and future applications

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Helix 8 and helix 10 are involved in substrate recognition in the rat monocarboxylate transporter MCT1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Oncogenic alterations of metabolism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

The contribution of lactic acid to acidification of tumours: studies of variant cells lacking lactate dehydrogenase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Transport of lactate and other monocarboxylates across mammalian plasma membranes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Studies with glycolysis-deficient cells suggest that production of lactic acid is not the only cause of tumor acidity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Tumorigenic 3T3 cells maintain an alkaline intracellular pH under physiological conditions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Expression of the hypoxia-inducible monocarboxylate transporter MCT4 is increased in triple negative breast cancer and correlates independently with clinical outcome.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Dysregulated pH: a perfect storm for cancer progression.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Tissue distribution of basigin and monocarboxylate transporter 1 in the adult male mouse: a study using the wild-type and basigin gene knockout mice

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Mouse MCT3 gene is expressed preferentially in retinal pigment and choroid plexus epithelia

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Endurance training, expression, and physiology of LDH, MCT1, and MCT4 in human skeletal muscle

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Transforming growth factor beta2 promotes glucose carbon incorporation into nucleic acid ribose through the nonoxidative pentose cycle in lung epithelial carcinoma cells

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Regulation of GLUT1 gene transcription by the serine/threonine kinase Akt1.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Studies of the membrane topology of the rat erythrocyte H+/lactate cotransporter (MCT1).

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Alternative-substrate inhibition of L-lactate transport via the monocarboxylate-specific carrier system in human erythrocytes.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Angiogenesis induced by degradation products of hyaluronic acid.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Genetic disruption of lactate/H+ symporters (MCTs) and their subunit CD147/BASIGIN sensitizes glycolytic tumor cells to phenformin.

20 June 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-015-1307-X

Glucose metabolism heterogeneity in human and mouse malignant glioma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-015-1307-X

GLUT1 and GLUT3 as potential prognostic markers for Oral Squamous Cell Carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-015-1307-X

Glucose transporter GLUT1 expression is an stage-independent predictor of clinical outcome in adrenocortical carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-015-1307-X

Insulin regulation of glucose-6-phosphate dehydrogenase gene expression is rapamycin-sensitive and requires phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-015-1307-X

A microenvironmental model of carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-015-1307-X

Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-015-1307-X

Lactate stimulates endothelial cell migration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-015-1307-X

Peritoneal dialysis solutions inhibit the differentiation and maturation of human monocyte-derived dendritic cells: effect of lactate and glucose-degradation products

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-015-1307-X

Kinetic analysis of L-lactate transport in human erythrocytes via the monocarboxylate-specific carrier system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-015-1307-X

The loop between helix 4 and helix 5 in the monocarboxylate transporter MCT1 is important for substrate selection and protein stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-015-1307-X

Relative distribution of three major lactate transporters in frozen human tissues and their localization in unfixed skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-015-1307-X

Regulation of monocarboxylate transporter 1 (MCT1) promoter by butyrate in human intestinal epithelial cells: involvement of NF-kappaB pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-015-1307-X

Testosterone increases lactate transport, monocarboxylate transporter (MCT) 1 and MCT4 in rat skeletal muscle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-015-1307-X

Differences in metabolism between adeno- and squamous cell non-small cell lung carcinomas: spatial distribution and prognostic value of GLUT1 and MCT4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-015-1307-X

Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: a metabolic survival role for tumor-associated stroma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-015-1307-X

The reverse Warburg effect in osteosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-015-1307-X

HAb18G (CD147), a cancer-associated biomarker and its role in cancer detection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-015-1307-X

Co-expression of CD147/EMMPRIN with monocarboxylate transporters and multiple drug resistance proteins is associated with epithelial ovarian cancer progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-015-1307-X

CD147 silencing inhibits lactate transport and reduces malignant potential of pancreatic cancer cells in in vivo and in vitro models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-015-1307-X

The specific monocarboxylate transporter (MCT1) inhibitor, AR-C117977, a novel immunosuppressant, prolongs allograft survival in the mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-015-1307-X

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-015-1307-X

Addition of 2-deoxyglucose enhances growth inhibition but reverses acidification in colon cancer cells treated with phenformin.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4762928

Inhibitory effect of tumor cell-derived lactic acid on human T cells

27 November 2018

1 reference

12 December 2020

A null mutation in basigin, an immunoglobulin superfamily member, indicates its important roles in peri-implantation development and spermatogenesis

1 reference

12 December 2020

Retinal dysfunction in basigin deficiency

1 reference

12 December 2020

High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers

1 reference

12 December 2020

Functional distinction of rat liver natural killer cells from spleen natural killer cells under normal and acidic conditions in vitro

1 reference

12 December 2020

Metabolic and proteomic differentials in head and neck squamous cell carcinomas and normal gingival tissue

1 reference

12 December 2020

10.1007/S00109-015-1307-X

Identifiers

DOI

1 reference

Dimensions Publication ID

1035298086

0 references

1 reference

1 reference

PubMed publication ID

26099350

1 reference