Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways (Q28346530)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11160134%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

title

Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways (English)

1 reference

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3 November 2019

0 references

1 reference

1 reference

4

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3 November 2019

author name string

L Rui

1

1 reference

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3 November 2019

V Aguirre

2

1 reference

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3 November 2019

J K Kim

3

1 reference

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3 November 2019

A Lee

5

1 reference

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3 November 2019

A Corbould

6

1 reference

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3 November 2019

A Dunaif

7

1 reference

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3 November 2019

M F White

8

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3 November 2019

language of work or name

English

0 references

publication date

1 January 2001

1 reference

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Journal of Clinical Investigation

3 November 2019

published in

1 reference

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3 November 2019

volume

107

1 reference

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3 November 2019

issue

2

1 reference

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3 November 2019

page(s)

181-189

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The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

3 November 2019

cites work

1 reference

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Disruption of IRS-2 causes type 2 diabetes in mice

20 March 2017

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Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

20 March 2017

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Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

20 March 2017

1 reference

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A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphory

20 March 2017

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Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance

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6 April 2017

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Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

7 April 2017

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IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance

7 April 2017

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Signaling pathways in insulin action: molecular targets of insulin resistance

7 April 2017

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The role of TNFalpha and TNF receptors in obesity and insulin resistance

29 September 2017

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Mechanisms of TNF-alpha-induced insulin resistance

29 September 2017

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Insulin resistance and diabetes mellitus

29 September 2017

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Insulin signal transduction and the IRS proteins

29 September 2017

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Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase

29 September 2017

1 reference

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Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action

29 September 2017

1 reference

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Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells

29 September 2017

1 reference

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Interaction between the p21ras GTPase activating protein and the insulin receptor

29 September 2017

1 reference

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Persistent activation of phosphatidylinositol 3-kinase causes insulin resistance due to accelerated insulin-induced insulin receptor substrate-1 degradation in 3T3-L1 adipocytes

29 September 2017

1 reference

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Platelet-derived growth factor inhibits insulin stimulation of insulin receptor substrate-1-associated phosphatidylinositol 3-kinase in 3T3-L1 adipocytes without affecting glucose transport

2 June 2018

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2 June 2018

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Protein kinase C modulates the insulin-stimulated increase in Akt1 and Akt3 activity in 3T3-L1 adipocytes

2 June 2018

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Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase

2 June 2018

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The IRS-signalling system during insulin and cytokine action

2 June 2018

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Tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction.

2 June 2018

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Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling.

2 June 2018

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Insulin receptor substrate 1 is phosphorylated by the serine kinase activity of phosphatidylinositol 3-kinase

2 June 2018

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2 June 2018

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Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

2 June 2018

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Regulation of the insulin signalling pathway by cellular protein-tyrosine phosphatases

27 November 2018

1 reference

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The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1. Stimulation by insulin and inhibition by Wortmannin

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11160134

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Tumor necrosis factor alpha-induced phosphorylation of insulin receptor substrate-1 (IRS-1). Possible mechanism for suppression of insulin-stimulated tyrosine phosphorylation of IRS-1

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11160134

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1172/JCI10934

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11160134%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11160134%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

PubMed publication ID

11160134

2 references