How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis (Q30654593)

18 October 2017

How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis (English)

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18 October 2017

Young-Sam Lee

1

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18 October 2017

Yang Gao

series ordinal

2

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18 October 2017

Wei Yang

series ordinal

3

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18 October 2017

16 March 2015

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Nature Structural & Molecular Biology

18 October 2017

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18 October 2017

22

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18 October 2017

4

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18 October 2017

298-303

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describes a project that uses

18 October 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4469489/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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An overview of Y-Family DNA polymerases and a case study of human DNA polymerase η

20 June 2018

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Human Pol ζ purified with accessory subunits is active in translesion DNA synthesis and complements Pol η in cisplatin bypass

20 June 2018

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To switch or not to switch: at the origin of repeat expansion disease

20 June 2018

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DNA damage tolerance and a web of connections with DNA repair at Yale

20 June 2018

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Structural basis for processive DNA synthesis by yeast DNA polymerase ɛ

20 June 2018

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A brief history of triplet repeat diseases

20 June 2018

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Mechanism of somatic hypermutation at the WA motif by human DNA polymerase η.

20 June 2018

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Dual role for mammalian DNA polymerase ζ in maintaining genome stability and proliferative responses

20 June 2018

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DNA polymerase POLQ and cellular defense against DNA damage

20 June 2018

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Structural basis of human DNA polymerase η-mediated chemoresistance to cisplatin.

20 June 2018

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Kinetic analysis of the unique error signature of human DNA polymerase ν.

20 June 2018

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Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis

20 June 2018

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The Structure of a High Fidelity DNA Polymerase Bound to a Mismatched Nucleotide Reveals an “Ajar” Intermediate Conformation in the Nucleotide Selection Mechanism

20 June 2018

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Lesion bypass activity of DNA polymerase θ (POLQ) is an intrinsic property of the pol domain and depends on unique sequence inserts.

20 June 2018

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Purified human BRCA2 stimulates RAD51-mediated recombination

20 June 2018

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DNA polymerases nu and theta are required for efficient immunoglobulin V gene diversification in chicken

20 June 2018

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Evolutionary conservation of residues in vertebrate DNA polymerase N conferring low fidelity and bypass activity

20 June 2018

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

20 June 2018

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Structural Insight into Translesion Synthesis by DNA Pol II

20 June 2018

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Refolding active human DNA polymerase nu from inclusion bodies.

20 June 2018

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Structural insight into processive human mitochondrial DNA synthesis and disease-related polymerase mutations

20 June 2018

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Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase delta

20 June 2018

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DNA polymerase proofreading: Multiple roles maintain genome stability

20 June 2018

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A movie of the RNA polymerase nucleotide addition cycle.

20 June 2018

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Structure of PolC reveals unique DNA binding and fidelity determinants

20 June 2018

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Low-fidelity DNA synthesis by human DNA polymerase theta.

20 June 2018

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What a difference a decade makes: insights into translesion DNA synthesis

20 June 2018

1 reference

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The X family portrait: structural insights into biological functions of X family polymerases.

20 June 2018

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A unique error signature for human DNA polymerase nu

20 June 2018

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A time- and cost-efficient system for high-level protein production in mammalian cells

20 June 2018

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Visualizing polynucleotide polymerase machines at work

20 June 2018

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A closed conformation for the Pol lambda catalytic cycle.

20 June 2018

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Coot: model-building tools for molecular graphics

20 June 2018

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High-efficiency bypass of DNA damage by human DNA polymerase Q

20 June 2018

1 reference

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POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cells

20 June 2018

1 reference

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POLN, a nuclear PolA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308

20 June 2018

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Processive DNA synthesis observed in a polymerase crystal suggests a mechanism for the prevention of frameshift mutations

20 June 2018

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Structural basis for the transition from initiation to elongation transcription in T7 RNA polymerase

20 June 2018

1 reference

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Evidence of cis-acting factors in replication-mediated trinucleotide repeat instability in primate cells.

20 June 2018

1 reference

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Cloning and chromosomal mapping of the human DNA polymerase theta (POLQ), the eighth human DNA polymerase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4469489

An open and closed case for all polymerases.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4469489

Crystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: structural basis for nucleotide incorporation.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4469489

Human DNA polymerase N (POLN) is a low fidelity enzyme capable of error-free bypass of 5S-thymine glycol.

20 June 2018

1 reference

DNA polymerase theta (POLQ) can extend from mismatches and from bases opposite a (6-4) photoproduct

21 January 2018

1 reference

A Polymerase Theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites

21 January 2018

1 reference

Disruption of the Rev3l-encoded catalytic subunit of polymerase zeta in mice results in early embryonic lethality.

21 January 2018

1 reference

Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

GAA instability in Friedreich's Ataxia shares a common, DNA-directed and intraallelic mechanism with other trinucleotide diseases

21 January 2018

1 reference

31 March 2020

Identifiers

DOI

10.1038/NSMB.2985

1 reference

18 October 2017

1 reference

18 October 2017

PubMed publication ID

25775266

1 reference