The development and therapeutic potential of protein kinase inhibitors (Q33695725)

28 July 2017

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title

The development and therapeutic potential of protein kinase inhibitors (English)

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28 July 2017

Cohen P

1

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28 July 2017

publication date

1 August 1999

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Current Opinion in Chemical Biology

28 July 2017

published in

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28 July 2017

volume

3

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28 July 2017

issue

4

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28 July 2017

page(s)

459-465

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Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

28 July 2017

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Bcr-Abl kinase promotes cell cycle entry of primary myeloid CML cells in the absence of growth factors

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In vivo eradication of human BCR/ABL-positive leukemia cells with an ABL kinase inhibitor

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Leflunomide inhibits pyrimidine de novo synthesis in mitogen-stimulated T-lymphocytes from healthy humans

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Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

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7 January 2021

Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

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7 January 2021

Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain.

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7 January 2021

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

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7 January 2021

Identification of a novel inhibitor of mitogen-activated protein kinase kinase

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7 January 2021

Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

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7 January 2021

Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors

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7 January 2021

Mechanism of activation and function of protein kinase B.

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7 January 2021

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

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7 January 2021

The effects of the Rho-kinase inhibitor Y-27632 on arachidonic acid-, GTPgammaS-, and phorbol ester-induced Ca2+-sensitization of smooth muscle

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7 January 2021

Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)

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7 January 2021

Transformation mediated by RhoA requires activity of ROCK kinases

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7 January 2021

An essential part for Rho-associated kinase in the transcellular invasion of tumor cells.

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7 January 2021

Rho-kinase in human neutrophils: a role in signalling for myosin light chain phosphorylation and cell migration

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7 January 2021

Na-H exchange acts downstream of RhoA to regulate integrin-induced cell adhesion and spreading

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7 January 2021

Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase

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7 January 2021

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

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7 January 2021

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1

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7 January 2021

The search for physiological substrates of MAP and SAP kinases in mammalian cells

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7 January 2021

TOR signalling and control of cell growth

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7 January 2021

Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors

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7 January 2021

A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket

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7 January 2021

The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase

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7 January 2021

Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine

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7 January 2021

Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution

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7 January 2021

Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket

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7 January 2021

Direct Inhibition of Cyclooxygenase-1 and -2 by the Kinase Inhibitors SB 203580 and PD 98059

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7 January 2021

Protein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport

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7 January 2021

The protein kinase C inhibitors Ro 318220 and GF 109203X are equally potent inhibitors of MAPKAP kinase-1beta (Rsk-2) and p70 S6 kinase.

1 reference

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7 January 2021

Use of a drug-resistant mutant of stress-activated protein kinase 2a/p38 to validate the in vivo specificity of SB 203580.

1 reference

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7 January 2021

Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases

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7 January 2021

The activation state of p38 mitogen-activated protein kinase determines the efficiency of ATP competition for pyridinylimidazole inhibitor binding

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7 January 2021

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

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7 January 2021

10.1016/S1367-5931(99)80067-2

Identifiers

DOI

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28 July 2017

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