Activated Drosophila Ras1 is selectively suppressed by isoprenyl transferase inhibitors (Q33743285)

29 July 2017

title

Activated Drosophila Ras1 is selectively suppressed by isoprenyl transferase inhibitors (English)

1 reference

29 July 2017

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R C Kauffmann

1

1 reference

29 July 2017

Y Qian

2

1 reference

29 July 2017

A Vogt

3

1 reference

29 July 2017

S M Sebti

4

1 reference

29 July 2017

A D Hamilton

5

1 reference

29 July 2017

R W Carthew

6

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29 July 2017

language of work or name

English

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publication date

1 November 1995

1 reference

Proceedings of the National Academy of Sciences of the United States of America

29 July 2017

published in

1 reference

29 July 2017

volume

92

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29 July 2017

issue

24

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29 July 2017

page(s)

10919-10923

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Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo.

29 July 2017

cites work

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21 June 2018

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21 June 2018

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Isoprenoid diphosphate utilization by recombinant human farnesyl:protein transferase: interactive binding between substrates and a preferred kinetic pathway.

21 June 2018

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The torso receptor protein-tyrosine kinase signaling pathway: an endless story

21 June 2018

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Genetic evidence for in vivo cross-specificity of the CaaX-box protein prenyltransferases farnesyltransferase and geranylgeranyltransferase-I in Saccharomyces cerevisiae

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40542

Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor

21 June 2018

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21 June 2018

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Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

21 June 2018

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The Drosophila rolled locus encodes a MAP kinase required in the sevenless signal transduction pathway.

21 June 2018

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Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice

21 June 2018

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Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40542

CAAX peptidomimetic FTI-244 decreases platelet-derived growth factor receptor tyrosine phosphorylation levels and inhibits stimulation of phosphatidylinositol 3-kinase but not mitogen-activated protein kinase

21 June 2018

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p21ras is modified by a farnesyl isoprenoid

21 June 2018

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All ras proteins are polyisoprenylated but only some are palmitoylated

21 June 2018

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Genetic and pharmacological suppression of oncogenic mutations in ras genes of yeast and humans.

21 June 2018

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ras oncogenes in human cancer: a review

21 June 2018

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Polyisoprenylation of Ras in vitro by a farnesyl-protein transferase

21 June 2018

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Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

21 June 2018

1 reference

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Posttranslationally processed structure of the human platelet protein smg p21B: evidence for geranylgeranylation and carboxyl methylation of the C-terminal cysteine

21 June 2018

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Ras C-terminal processing enzymes--new drug targets?

21 June 2018

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Ligand-independent activation of the sevenless receptor tyrosine kinase changes the fate of cells in the developing Drosophila eye.

21 June 2018

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The homeo domain protein rough is expressed in a subset of cells in the developing Drosophila eye where it can specify photoreceptor cell subtype

21 June 2018

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The Drosophila roughened mutation: activation of a rap homolog disrupts eye development and interferes with cell determination

21 June 2018

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Nonfarnesylated tetrapeptide inhibitors of protein farnesyltransferase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40542

Sequence dependence of protein isoprenylation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40542

Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40542

Isopentenoid synthesis in embryonic Drosophila cells: prenylated protein profile and prenyl group usage

21 June 2018

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Protein prenylation: more than just glue?

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40542

Raf functions downstream of Ras1 in the Sevenless signal transduction pathway

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40542

Signalling by the sevenless protein tyrosine kinase is mimicked by Ras1 activation.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40542

Cell fate in the Drosophila ommatidium

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40542

Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells

30 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40542

A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40542

Potent inhibition of human tumor p21ras farnesyltransferase by A1A2-lacking p21ras CA1A2X peptidomimetics

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/7479910

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Design and structural requirements of potent peptidomimetic inhibitors of p21ras farnesyltransferase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/7479910

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A non-peptide mimetic of Ras-CAAX: selective inhibition of farnesyltransferase and Ras processing

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/7479910

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.92.24.10919

1 reference

29 July 2017

0 references

1 reference

29 July 2017

1 reference