Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro/Milton complex (Q33779586)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20335458%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

title

Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro/Milton complex (English)

1 reference

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29 January 2020

1 reference

2

1 reference

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29 January 2020

Jeffrey Milbrandt

series ordinal

4

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29 January 2020

5

Robert H Baloh

1 reference

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29 January 2020

author name string

Albert Misko

series ordinal

1

1 reference

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29 January 2020

Iga Wegorzewska

series ordinal

3

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29 January 2020

language of work or name

English

0 references

publication date

1 March 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20335458%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

published in

Journal of Neuroscience

1 reference

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29 January 2020

volume

30

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29 January 2020

issue

12

1 reference

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29 January 2020

page(s)

4232-4240

1 reference

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HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport

29 January 2020

cites work

1 reference

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GTPase dependent recruitment of Grif-1 by Miro1 regulates mitochondrial trafficking in hippocampal neurons

28 July 2018

1 reference

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Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase

28 July 2018

1 reference

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Mitofusin 2 tethers endoplasmic reticulum to mitochondria

28 July 2018

1 reference

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Mitochondrial dynamics and apoptosis

28 July 2018

1 reference

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Role of axonal transport in neurodegenerative diseases

28 July 2018

1 reference

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Mitochondrial dynamics and peripheral neuropathy

28 July 2018

1 reference

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Complementation between mouse Mfn1 and Mfn2 protects mitochondrial fusion defects caused by CMT2A disease mutations

28 July 2018

1 reference

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Altered axonal mitochondrial transport in the pathogenesis of Charcot-Marie-Tooth disease from mitofusin 2 mutations

28 July 2018

1 reference

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The genetics of axonal transport and axonal transport disorders

28 July 2018

1 reference

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Mitochondria: dynamic organelles in disease, aging, and development

28 July 2018

1 reference

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Axonal transport of mitochondria requires milton to recruit kinesin heavy chain and is light chain independent

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852190

The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852190

The axonal transport of mitochondria.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852190

Hereditary optic neuropathies: from the mitochondria to the optic nerve

28 July 2018

1 reference

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Disruption of fusion results in mitochondrial heterogeneity and dysfunction

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852190

Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852190

OPA1 requires mitofusin 1 to promote mitochondrial fusion

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852190

Two Mitofusin Proteins, Mammalian Homologues of FZO, with Distinct Functions Are Both Required for Mitochondrial Fusion

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852190

A review of primary hereditary optic neuropathies

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852190

The intramitochondrial dynamin-related GTPase, Mgm1p, is a component of a protein complex that mediates mitochondrial fusion

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852190

Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852190

Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852190

Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852190

OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852190

Cytoplasmic dynein, the dynactin complex, and kinesin are interdependent and essential for fast axonal transport

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852190

Axoplasmic organelles at nodes of Ranvier. I. Occurrence and distribution in large myelinated spinal root axons of the adult cat.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852190

A monoclonal antibody against kinesin inhibits both anterograde and retrograde fast axonal transport in squid axoplasm

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852190

Mitochondrial and axonal abnormalities precede disruption of the neurofilament network in a model of charcot-marie-tooth disease type 2E and are prevented by heat shock proteins in a mutant-specific fashion.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852190

Drosophila Miro is required for both anterograde and retrograde axonal mitochondrial transport.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852190

Miro1 is a calcium sensor for glutamate receptor-dependent localization of mitochondria at synapses.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852190

Docking of axonal mitochondria by syntaphilin controls their mobility and affects short-term facilitation

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852190

Hindlimb gait defects due to motor axon loss and reduced distal muscles in a transgenic mouse model of Charcot-Marie-Tooth type 2A.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852190

Mitochondrial fusion protects against neurodegeneration in the cerebellum.

30 October 2018

1 reference

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MFN2 mutation distribution and genotype/phenotype correlation in Charcot-Marie-Tooth type 2.

30 October 2018

1 reference

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The GTPase dMiro is required for axonal transport of mitochondria to Drosophila synapses.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852190

The Charcot-Marie-Tooth type 2A gene product, Mfn2, up-regulates fuel oxidation through expression of OXPHOS system

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852190

Deficit of in vivo mitochondrial ATP production in OPA1-related dominant optic atrophy

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852190

Mitochondrial accumulation in the distal part of the initial segment of chicken spinal motoneurons.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852190

Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852190

Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852190

Dynactin is required for bidirectional organelle transport

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852190

Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852190

The interaction between cytoplasmic dynein and dynactin is required for fast axonal transport

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852190

Clinical and electrophysiologic features of CMT2A with mutations in the mitofusin 2 gene

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20335458

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Imaging axonal transport of mitochondria in vivo

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20335458

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1523/JNEUROSCI.6248-09.2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20335458%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20335458%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

PubMed publication ID

20335458

1 reference