Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage (Q33935906)

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9 January 2020

title

Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage (English)

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9 January 2020

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1 reference

3

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9 January 2020

Mogjiborahman Salek

6

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9 January 2020

author name string

Yaron Pereg

1

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9 January 2020

Dganit Shkedy

2

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9 January 2020

Erik Meulmeester

4

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9 January 2020

Marina Edelson-Averbukh

5

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9 January 2020

Sharon Biton

7

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9 January 2020

Amina F A S Teunisse

8

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9 January 2020

Wolf D Lehmann

9

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9 January 2020

Aart G Jochemsen

10

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9 January 2020

Yosef Shiloh

11

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9 January 2020

language of work or name

English

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publication date

23 March 2005

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Proceedings of the National Academy of Sciences of the United States of America

9 January 2020

published in

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9 January 2020

volume

102

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9 January 2020

issue

14

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9 January 2020

page(s)

5056-5061

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Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

9 January 2020

cites work

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Ataxia-telangiectasia, an evolving phenotype

5 July 2018

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The p53 response to DNA damage

5 July 2018

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Mammalian cell cycle checkpoints: signalling pathways and their organization in space and time

5 July 2018

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DNA damage-induced activation of ATM and ATM-dependent signaling pathways

5 July 2018

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5 July 2018

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The cellular response to general and programmed DNA double strand breaks

5 July 2018

1 reference

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Mdmx and Mdm2: brothers in arms?

5 July 2018

1 reference

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Initiating cellular stress responses

5 July 2018

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To die or not to die: how does p53 decide?

5 July 2018

1 reference

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Posttranslational modification of MDM2

5 July 2018

1 reference

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The MDM2-p53 interaction.

5 July 2018

1 reference

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DNA damage-induced MDMX degradation is mediated by MDM2.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555986

Hdmx protein stability is regulated by the ubiquitin ligase activity of Mdm2.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555986

MDM2 promotes ubiquitination and degradation of MDMX

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555986

Decision making by p53: life, death and cancer

5 July 2018

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5 July 2018

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555986

DNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanisms

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555986

MDMX inhibits the p300/CBP-mediated acetylation of p53

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555986

Sensing and repairing DNA double-strand breaks

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555986

Mutual dependence of MDM2 and MDMX in their functional inactivation of p53

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555986

The p53 and Mdm2 families in cancer.

5 July 2018

1 reference

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Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555986

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

5 July 2018

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Aberrant expression of HDMX proteins in tumor cells correlates with wild-type p53.

5 July 2018

1 reference

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Cellular responses to DNA damage

5 July 2018

1 reference

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MdmX protects p53 from Mdm2-mediated degradation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555986

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555986

Enhanced phosphorylation of p53 by ATM in response to DNA damage

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555986

Mapping of the p53 and mdm-2 Interaction Domains

5 July 2018

1 reference

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Functional role of Mdm2 phosphorylation by ATR in attenuation of p53 nuclear export

5 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0408595102

Phosphorylation site interdependence of human p53 post-translational modifications in response to stress

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0408595102

Nuclear retention of ATM at sites of DNA double strand breaks

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0408595102

Hdmx stabilizes Mdm2 and p53

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15788536

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Comparative study of the p53-mdm2 and p53-MDMX interfaces

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15788536

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0408595102

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15788536%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

0 references

1 reference

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9 January 2020

PubMed publication ID

15788536

1 reference