Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease. (Q34075502)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12149470%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

title

Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease (English)

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11 November 2019

0 references

1

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11 November 2019

Cecília Rodrigues

2

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11 November 2019

5

Clifford J Steer

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11 November 2019

author name string

Tacjana Eich

3

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11 November 2019

Manik S Chhabra

4

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11 November 2019

Walter C Low

6

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11 November 2019

language of work or name

English

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publication date

29 July 2002

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Proceedings of the National Academy of Sciences of the United States of America

11 November 2019

published in

1 reference

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11 November 2019

volume

99

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11 November 2019

issue

16

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11 November 2019

page(s)

10671-10676

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Effects of intracellular expression of anti-huntingtin antibodies of various specificities on mutant huntingtin aggregation and toxicity

11 November 2019

cites work

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5 July 2018

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Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease

5 July 2018

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5 July 2018

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Amyloid beta-peptide disrupts mitochondrial membrane lipid and protein structure: protective role of tauroursodeoxycholate.

5 July 2018

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5 July 2018

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Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease

5 July 2018

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Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease.

5 July 2018

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Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice

5 July 2018

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Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells

5 July 2018

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Caspases and neurodegeneration: on the cutting edge of new therapeutic approaches.

5 July 2018

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Recent insights into the molecular pathogenesis of Huntington disease

5 July 2018

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Mitochondrial dysfunction and free radical damage in the Huntington R6/2 transgenic mouse.

5 July 2018

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Replicating Huntington's disease phenotype in experimental animals

5 July 2018

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Ursodeoxycholic acid prevents cytochrome c release in apoptosis by inhibiting mitochondrial membrane depolarization and channel formation

5 July 2018

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Altered neurotransmitter receptor expression in transgenic mouse models of Huntington's disease

5 July 2018

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Ultrastructural localization and progressive formation of neuropil aggregates in Huntington's disease transgenic mice

5 July 2018

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Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

5 July 2018

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Caspase-8 is required for cell death induced by expanded polyglutamine repeats.

5 July 2018

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Huntington's disease intranuclear inclusions contain truncated, ubiquitinated huntingtin protein

5 July 2018

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Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation.

5 July 2018

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Oxidative stress in Huntington's disease

5 July 2018

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In vitro evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease.

5 July 2018

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A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation

5 July 2018

1 reference

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The influence of huntingtin protein size on nuclear localization and cellular toxicity.

5 July 2018

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Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human huntington disease gene

5 July 2018

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Ursodeoxycholic acid may inhibit deoxycholic acid-induced apoptosis by modulating mitochondrial transmembrane potential and reactive oxygen species production

5 July 2018

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Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates

5 July 2018

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Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

5 July 2018

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3-Nitropropionic acid animal model and Huntington's disease

5 July 2018

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Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia.

5 July 2018

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Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

5 July 2018

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

5 July 2018

1 reference

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Cortical and subcortical glucose consumption measured by PET in patients with Huntington's disease.

5 July 2018

1 reference

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Energy metabolism defects in Huntington's disease and effects of coenzyme Q10.

5 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.162362299

Evidence for impairment of energy metabolism in vivo in Huntington's disease using localized 1H NMR spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.162362299

Mitochondrial defect in Huntington's disease caudate nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.162362299

Biochemical abnormalities and excitotoxicity in Huntington's disease brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.162362299

Correction of hemophilia B in canine and murine models using recombinant adeno-associated viral vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.162362299

Trinucleotide (CAG) repeat length is positively correlated with the degree of DNA fragmentation in Huntington's disease striatum

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.162362299

Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.162362299

DNA End Labeling (TUNEL) in Huntington's Disease and Other Neuropathological Conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.162362299

Tauroursodeoxycholic acid partially prevents apoptosis induced by 3-nitropropionic acid: evidence for a mitochondrial pathway independent of the permeability transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.162362299

A bile acid protects against motor and cognitive deficits and reduces striatal degeneration in the 3-nitropropionic acid model of Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.162362299

Creatine-supplemented diet extends Purkinje cell survival in spinocerebellar ataxia type 1 transgenic mice but does not prevent the ataxic phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.162362299

Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.162362299

Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.162362299

Neuroprotection by a bile acid in an acute stroke model in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.162362299

Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125009

Abnormal in vivo skeletal muscle energy metabolism in Huntington's disease and dentatorubropallidoluysian atrophy

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125009

Mutant huntingtin expression in clonal striatal cells: dissociation of inclusion formation and neuronal survival by caspase inhibition.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125009

Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125009

In situ evidence for DNA fragmentation in Huntingtonʼs disease striatum and Alzheimerʼs disease temporal lobes

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125009

Effect of tauroursodeoxycholic acid on bile-acid-induced apoptosis and cytolysis in rat hepatocytes

28 October 2018

1 reference

12 December 2020

Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization

1 reference

12 December 2020

Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity

1 reference

12 December 2020

Effect of tauroursodeoxycholic acid on bile acid-induced apoptosis in primary human hepatocytes

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.162362299

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12149470%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12149470%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

PubMed publication ID

12149470

1 reference