Hexosamines as mediators of nutrient sensing and regulation in diabetes. (Q34548619)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11872372%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

review article

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title

Hexosamines as mediators of nutrient sensing and regulation in diabetes (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11872372%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

1

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7 December 2019

author name string

Donald A McClain

series ordinal

1

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2 August 2017

publication date

1 January 2002

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11872372%20AND%20SRC:MED&resulttype=core&format=json

Journal of Diabetes and its Complications

7 December 2019

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11872372%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

volume

16

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7 December 2019

issue

1

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7 December 2019

page(s)

72-80

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Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

7 December 2019

cites work

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Glucosamine induces insulin resistance in vivo by affecting GLUT 4 translocation in skeletal muscle. Implications for glucose toxicity

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7 January 2021

A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance

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c-Myc Is Glycosylated at Threonine 58, a Known Phosphorylation Site and a Mutational Hot Spot in Lymphomas

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7 January 2021

O-Glycosylation of nuclear and cytosolic proteins. Dynamic interplay between O-GlcNAc and O-phosphate

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Mechanism of hexosamine-induced insulin resistance in transgenic mice overexpressing glutamine:fructose-6-phosphate amidotransferase: decreased glucose transporter GLUT4 translocation and reversal by treatment with thiazolidinedione.

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7 January 2021

Glutamine:fructose-6-phosphate amidotransferase activity in cultured human skeletal muscle cells: relationship to glucose disposal rate in control and non-insulin-dependent diabetes mellitus subjects and regulation by glucose and insulin

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In vivo effects of glucosamine on insulin secretion and insulin sensitivity in the rat: possible relevance to the maladaptive responses to chronic hyperglycaemia

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Reduced O glycosylation of Sp1 is associated with increased proteasome susceptibility

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Glycosylation in the nucleus and cytoplasm

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Sterol regulatory element-binding protein-1 is regulated by glucose at the transcriptional level.

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Role of the glucosamine pathway in fat-induced insulin resistance

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Overexpression of glutamine:fructose-6-phosphate amidotransferase in transgenic mice leads to insulin resistance

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7 January 2021

Obesity-independent hyperinsulinemia in nondiabetic first-degree relatives of individuals with type 2 diabetes

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7 January 2021

O-glycosylation of eukaryotic transcription factors: implications for mechanisms of transcriptional regulation

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SPINDLY, a tetratricopeptide repeat protein involved in gibberellin signal transduction in Arabidopsis

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Insights into insulin resistance and type 2 diabetes from knockout mouse models

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Five mutant alleles of the insulin receptor gene in patients with genetic forms of insulin resistance

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7 January 2021

Lymphocyte activation induces rapid changes in nuclear and cytoplasmic glycoproteins

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Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.

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7 January 2021

Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle.

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7 January 2021

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

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7 January 2021

Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines

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7 January 2021

Progressive decline in insulin levels in Rabson-Mendenhall syndrome

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7 January 2021

Hexosamines stimulate leptin production in transgenic mice

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7 January 2021

Effects of glucosamine infusion on insulin secretion and insulin action in humans

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7 January 2021

Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle

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7 January 2021

O glycosylation of an Sp1-derived peptide blocks known Sp1 protein interactions

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7 January 2021

In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats

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7 January 2021

The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny

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7 January 2021

Glucosamine infusion in rats mimics the beta-cell dysfunction of non-insulin-dependent diabetes mellitus

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7 January 2021

SSN genes that affect transcriptional repression in Saccharomyces cerevisiae encode SIN4, ROX3, and SRB proteins associated with RNA polymerase II

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7 January 2021

Human glucokinase gene: isolation, characterization, and identification of two missense mutations linked to early-onset non-insulin-dependent (type 2) diabetes mellitus

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7 January 2021

Early-onset type-II diabetes mellitus (MODY4) linked to IPF1

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7 January 2021

Transgenic mice with increased hexosamine flux specifically targeted to beta-cells exhibit hyperinsulinemia and peripheral insulin resistance

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7 January 2021

Overexpression of glutamine: fructose-6-phosphate amidotransferase in the liver of transgenic mice results in enhanced glycogen storage, hyperlipidemia, obesity, and impaired glucose tolerance

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7 January 2021

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7 January 2021

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7 January 2021

The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus

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7 January 2021

Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)

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7 January 2021

UDP-N-acetylglucosamine transferase and glutamine: fructose 6-phosphate amidotransferase activities in insulin-sensitive tissues

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7 January 2021

Differential effects of troglitazone and D-chiroinositol on glucosamine-induced insulin resistance in vivo in rats

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7 January 2021

Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance.

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7 January 2021

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Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11872372%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

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