Tumor protein p73 (Q4197146)

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mammalian protein found in Homo sapiens
  • TP73
  • tumor protein p73
  • p53-like transcription factor
  • p53-related protein
  • TP73 protein, human
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Language Label Description Also known as
English
Tumor protein p73
mammalian protein found in Homo sapiens
  • TP73
  • tumor protein p73
  • p53-like transcription factor
  • p53-related protein
  • TP73 protein, human

Statements

molecular function
protein binding
determination method
IPI
15 references
retrieved
8 April 2019
stated in
ASPP1 and ASPP2: common activators of p53 family members
GOA
curator
UniProt
UniProt protein ID
O15350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350
determination method
IPI
retrieved
8 April 2019
stated in
The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73
GOA
curator
UniProt
UniProt protein ID
O15350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350
determination method
IPI
retrieved
8 April 2019
stated in
Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage
GOA
curator
UniProt
UniProt protein ID
O15350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350
determination method
IPI
retrieved
8 April 2019
stated in
MDM2 and MDMX bind and stabilize the p53-related protein p73
GOA
curator
UniProt
UniProt protein ID
O15350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350
determination method
IPI
retrieved
8 April 2019
stated in
Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63, and p73
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350
determination method
IPI
retrieved
8 April 2019
stated in
Runt-related transcription factor 2 attenuates the transcriptional activity as well as DNA damage-mediated induction of pro-apoptotic TAp73 to regulate chemosensitivity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350
determination method
IPI
retrieved
8 April 2019
stated in
Molecular basis of the interactions between the p73 N terminus and p300: effects on transactivation and modulation by phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350
determination method
IPI
retrieved
8 April 2019
stated in
The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350
determination method
IPI
retrieved
8 April 2019
stated in
Ligand binding to WW tandem domains of YAP2 transcriptional regulator is under negative cooperativity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350
determination method
IPI
retrieved
8 April 2019
stated in
The ubiquitin-protein ligase Itch regulates p73 stability
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350
determination method
IPI
retrieved
8 April 2019
stated in
Aurora kinase-A inactivates DNA damage-induced apoptosis and spindle assembly checkpoint response functions of p73
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350
determination method
IPI
retrieved
8 April 2019
stated in
Differential control of TAp73 and DeltaNp73 protein stability by the ring finger ubiquitin ligase PIR2.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350
determination method
IPI
retrieved
8 April 2019
stated in
Differential effect of ik3-1/cables on p53- and p73-induced cell death
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350
determination method
IPI
retrieved
8 April 2019
stated in
SIRT1 interacts with p73 and suppresses p73-dependent transcriptional activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350
determination method
IPI
retrieved
8 April 2019
stated in
Apoptotic function of human PMS2 compromised by the nonsynonymous single-nucleotide polymorphic variant R20Q
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350
determination method
IPI
cell component
biological process
positive regulation of transcription by RNA polymerase II
determination method
IDA
5 references
retrieved
8 April 2019
stated in
Plk3 inhibits pro-apoptotic activity of p73 through physical interaction and phosphorylation
GOA
curator
UniProt
UniProt protein ID
O15350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350
determination method
IDA
retrieved
8 April 2019
stated in
Inhibitory role of Plk1 in the regulation of p73-dependent apoptosis through physical interaction and phosphorylation
GOA
curator
UniProt
UniProt protein ID
O15350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350
determination method
IDA
retrieved
8 April 2019
stated in
DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. [Corrected]
GOA
curator
UniProt
UniProt protein ID
O15350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350
determination method
IDA
retrieved
8 April 2019
stated in
Brn-3a/POU4F1 interacts with and differentially affects p73-mediated transcription
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350
determination method
IDA
retrieved
8 April 2019
stated in
A novel response element confers p63- and p73-specific activation of the WNT4 promoter
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350
determination method
IDA
Gene Atlas image
PBB GE TP73 220804 s at fs.png
732 × 530; 12 KB
0 references

Identifiers

MeSH descriptor ID
C000606460
subject named as
TP73 protein, human
0 references
PDB structure ID
 
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