Localised inhibition of FGF signalling in the third pharyngeal pouch is required for normal thymus and parathyroid organogenesis (Q42011177)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22912418%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

title

Localised inhibition of FGF signalling in the third pharyngeal pouch is required for normal thymus and parathyroid organogenesis (English)

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11 February 2020

2

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11 February 2020

Michiel Albertus Basson

6

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11 February 2020

author name string

Jennifer R Gardiner

1

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11 February 2020

Julie Gordon

3

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11 February 2020

Heiko Lickert

4

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11 February 2020

Nancy R Manley

5

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11 February 2020

language of work or name

English

0 references

publication date

1 September 2012

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11 February 2020

number of pages

11

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inferred from page(s)

published in

Development

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11 February 2020

volume

139

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11 February 2020

issue

18

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11 February 2020

page(s)

3456-3466

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Developmental stalling and organ-autonomous regulation of morphogenesis

11 February 2020

cites work

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Sprouty genes are essential for the normal development of epibranchial ganglia in the mouse embryo

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Sprouty genes prevent excessive FGF signalling in multiple cell types throughout development of the cerebellum.

5 June 2018

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Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2

5 June 2018

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Evidence for an early role for BMP4 signaling in thymus and parathyroid morphogenesis

5 June 2018

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FGF signaling is strictly required to maintain early telencephalic precursor cell survival

5 June 2018

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5 June 2018

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5 June 2018

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FGF15 promotes neurogenesis and opposes FGF8 function during neocortical development

5 June 2018

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Specific regions within the embryonic midbrain and cerebellum require different levels of FGF signaling during development.

5 June 2018

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An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors

5 June 2018

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Gcm2 is required for the differentiation and survival of parathyroid precursor cells in the parathyroid/thymus primordia

5 June 2018

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Dusp6 (Mkp3) is a negative feedback regulator of FGF-stimulated ERK signaling during mouse development

5 June 2018

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Dissection of Tbx1 and Fgf interactions in mouse models of 22q11DS suggests functional redundancy

5 June 2018

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Sprouty genes control diastema tooth development via bidirectional antagonism of epithelial-mesenchymal FGF signaling

5 June 2018

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Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers

5 June 2018

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Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1

5 June 2018

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Sprouty proteins: multifaceted negative-feedback regulators of receptor tyrosine kinase signaling.

5 June 2018

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The role of the endoderm in the development and evolution of the pharyngeal arches

5 June 2018

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Fgf8 expression defines a morphogenetic center required for olfactory neurogenesis and nasal cavity development in the mouse

5 June 2018

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Fibroblast growth factor signalling and regional specification of the pharyngeal ectoderm

5 June 2018

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Sprouty2, a mouse deafness gene, regulates cell fate decisions in the auditory sensory epithelium by antagonizing FGF signaling

5 June 2018

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Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction

5 June 2018

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Differential expression of Sonic hedgehog along the anterior-posterior axis regulates patterning of pharyngeal pouch endoderm and pharyngeal endoderm-derived organs

5 June 2018

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Developing a new paradigm for thymus organogenesis.

5 June 2018

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Requirements for FGF3 and FGF10 during inner ear formation

5 June 2018

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5 June 2018

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Dosage of Fgf8 determines whether cell survival is positively or negatively regulated in the developing forebrain

5 June 2018

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Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice.

5 June 2018

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An Fgf8 mouse mutant phenocopies human 22q11 deletion syndrome

5 June 2018

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Functions of FGF signalling from the apical ectodermal ridge in limb development

5 June 2018

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Thymopoiesis requires Pax9 function in thymic epithelial cells

5 June 2018

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Hoxa3 and pax1 regulate epithelial cell death and proliferation during thymus and parathyroid organogenesis

5 June 2018

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Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus

5 June 2018

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FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development

5 June 2018

1 reference

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Genetic ablation of parathyroid glands reveals another source of parathyroid hormone

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424047

Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424047

An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424047

The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424047

The role of Hoxa-3 in mouse thymus and thyroid development

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424047

Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5

5 June 2018

1 reference

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Modulation of Bmp4 signalling in the epithelial-mesenchymal interactions that take place in early thymus and parathyroid development in avian embryos.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424047

Fibroblast growth factor (FGF) gene expression in the developing cerebellum suggests multiple roles for FGF signaling during cerebellar morphogenesis and development

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424047

FRS2alpha is required for the separation, migration, and survival of pharyngeal-endoderm derived organs including thyroid, ultimobranchial body, parathyroid, and thymus.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424047

Bmp4 and Noggin expression during early thymus and parathyroid organogenesis.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424047

BMP signaling is required for normal thymus development.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424047

FGF8 is required for cell survival at distinct stages of nephrogenesis and for regulation of gene expression in nascent nephrons.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424047

Functional evidence for a single endodermal origin for the thymic epithelium.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424047

Aortic arch and pharyngeal phenotype in the absence of BMP-dependent neural crest in the mouse.

17 August 2018

1 reference

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Fgf8 is required for pharyngeal arch and cardiovascular development in the mouse.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424047

Expression of the ERK-specific MAP kinase phosphatase PYST1/MKP3 in mouse embryos during morphogenesis and early organogenesis

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424047

Zebrafish pea3 and erm are general targets of FGF8 signaling.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424047

Disregulation of ocular morphogenesis by lens-specific expression of FGF-3/int-2 in transgenic mice

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424047

Analysis of Fgf8 gene function in vertebrate development

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424047

Sox17-2A-iCre: A knock-in mouse line expressing Cre recombinase in endoderm and vascular endothelial cells

17 August 2018

1 reference

12 December 2020

Gcm2 and Foxn1 mark early parathyroid- and thymus-specific domains in the developing third pharyngeal pouch

1 reference

12 December 2020

Development of thymus, parathyroids, and ultimo-branchial bodies in NMRI and nude mice

1 reference

12 December 2020

Development of the thymus requires signaling through the fibroblast growth factor receptor R2-IIIb

1 reference

12 December 2020

Identifiers

DOI

10.1242/DEV.079400

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22912418%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22912418%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

PubMed publication ID

22912418

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22912418%20AND%20SRC:MED&resulttype=core&format=json