Checkpoint Kinase 1 Expression Predicts Poor Prognosis in Nigerian Breast Cancer Patients (Q42517538)

1 November 2017

title

Checkpoint Kinase 1 Expression Predicts Poor Prognosis in Nigerian Breast Cancer Patients (English)

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1 November 2017

Emad Rakha

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Andrew Green

object named as

Andrew Green

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Ian Ellis

object named as

Ian Ellis

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author name string

Henry Okuchukwu Ebili

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1 November 2017

Victoria O Iyawe

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1 November 2017

Kikelomo Rachel Adeleke

3

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1 November 2017

Babatunde Abayomi Salami

4

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1 November 2017

Adekunbiola Aina Banjo

5

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1 November 2017

Chris Nolan

6

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1 November 2017

Ayodeji Olayinka Johnson Agboola

10

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1 November 2017

publication date

26 October 2017

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Molecular Diagnosis and Therapy

1 November 2017

published in

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Molecular characteristics and prognostic features of breast cancer in Nigerian compared with UK women

1 November 2017

cites work

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Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control

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New insights into checkpoint kinase 1 in the DNA damage response signaling network

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Novel regulation of checkpoint kinase 1: Is checkpoint kinase 1 a good candidate for anti-cancer therapy?

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Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response.

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AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies

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Whole chromosome instability resulting from the synergistic effects of pRB and p53 inactivation

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Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma

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Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1.

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Acquisition of epithelial-mesenchymal transition and cancer stem cell phenotypes is associated with activation of the PI3K/Akt/mTOR pathway in prostate cancer radioresistance

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Clinicopathologic and molecular significance of phospho-Akt expression in early invasive breast cancer

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Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells

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P-Cadherin Linking Breast Cancer Stem Cells and Invasion: A Promising Marker to Identify an "Intermediate/Metastable" EMT State

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The severity, outcome and challenges of breast cancer in Nigeria

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Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening

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American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer

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Specific role of Chk1 phosphorylations in cell survival and checkpoint activation

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Characterization and preclinical development of LY2603618: a selective and potent Chk1 inhibitor

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BARD1 participates with BRCA1 in homology-directed repair of chromosome breaks

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MTA1-mediated transcriptional repression of BRCA1 tumor suppressor gene

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12 December 2020

CHK1 expression in Gastric Cancer is modulated by p53 and RB1/E2F1: implications in chemo/radiotherapy response

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12 December 2020

Suppressed miR-424 expression via upregulation of target gene Chk1 contributes to the progression of cervical cancer

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Genetic instability and mammary tumor formation in mice carrying mammary-specific disruption of Chk1 and p53.

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12 December 2020

Clinicopathological and molecular characteristics of Ku 70/80 expression in Nigerian breast cancer and its potential therapeutic implications

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Global gene expression profile of nasopharyngeal carcinoma by laser capture microdissection and complementary DNA microarrays.

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Chk1 is essential for chemical carcinogen-induced mouse skin tumorigenesis.

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The Chk2 protein kinase

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CHK1 targets spleen tyrosine kinase (L) for proteolysis in hepatocellular carcinoma.

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Targeting the checkpoint kinases: chemosensitization versus chemoprotection

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Regulation of DNA double-strand break repair pathway choice

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Cell Proliferation (KI-67) Expression Is Associated with Poorer Prognosis in Nigerian Compared to British Breast Cancer Women

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Molecular resistance fingerprint of pemetrexed and platinum in a long-term survivor of mesothelioma

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Chk1 inhibition as a novel therapeutic strategy for treating triple-negative breast and ovarian cancers

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RAD51 up-regulation bypasses BRCA1 function and is a common feature of BRCA1-deficient breast tumors

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12 December 2020

Role of checkpoint kinase 1 (Chk1) in the mechanisms of resistance to histone deacetylase inhibitors

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12 December 2020

Roles of Chk1 in cell biology and cancer therapy

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Chk'ing p53-deficient breast cancers

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12 December 2020

A proteomics analysis of cell signaling alterations in colorectal cancer

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12 December 2020

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

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12 December 2020

Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models.

1 reference

12 December 2020

Inhibition of PI-3K restores nuclear p27Kip1 expression in a mouse model of Kras-driven lung cancer

1 reference

12 December 2020

ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1.

1 reference

12 December 2020

[Expression of checkpoint kinase 1 and polo-like kinase 1 and its clinicopathological significance in benign and malignant lesions of the stomach].

1 reference

12 December 2020

Reporting recommendations for tumor marker prognostic studies

1 reference

12 December 2020

Checkpoint kinase1 (CHK1) is an important biomarker in breast cancer having a role in chemotherapy response

1 reference

12 December 2020

An extra allele of Chk1 limits oncogene-induced replicative stress and promotes transformation

1 reference

12 December 2020

Molecular profiling of breast cancer in Nigerian women identifies an altered p53 pathway as a major mechanism underlying its poor prognosis compared with British counterpart

1 reference

12 December 2020

10.1007/S40291-017-0302-Z

Identifiers

DOI

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1 November 2017

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