The Relationship between TP53 Gene Status and Carboxylesterase 2 Expression in Human Colorectal Cancer. (Q52719672)

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23 March 2020

title

The Relationship between TP53 Gene Status and Carboxylesterase 2 Expression in Human Colorectal Cancer (English)

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23 March 2020

1 reference

2

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23 March 2020

Hajime Orita

4

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23 March 2020

3

Hirofumi Nakaoka

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23 March 2020

author name string

Momoko Ishimine

1

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23 March 2020

Toshiyuki Kobayashi

5

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23 March 2020

Konomi Mizuguchi

6

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23 March 2020

Mikumi Endo

7

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23 March 2020

Ituro Inoue

8

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23 March 2020

Koichi Sato

9

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23 March 2020

Takehiko Yokomizo

10

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publication date

31 January 2018

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23 March 2020

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23 March 2020

volume

2018

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23 March 2020

page(s)

5280736

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Creative Commons Attribution 4.0 International

23 March 2020

copyright license

start time

1 January 2018

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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April 2022 Public Data File from Crossref

describes a project that uses

ImageQuant

object named as

ImageQuant TL

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11 June 2022

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inferred from PubMed Central ID database lookup

CZ Software Mentions: A large dataset of software mentions in the biomedical literature

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Regulation of carboxylesterase-2 expression by p53 family proteins and enhanced anti-cancer activities among 5-fluorouracil, irinotecan and doxazolidine prodrug

22 May 2018

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Human carboxylesterase-2 hydrolyzes the prodrug of gemcitabine (LY2334737) and confers prodrug sensitivity to cancer cells

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Activity-based proteomics of enzyme superfamilies: serine hydrolases as a case study

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The expanding universe of p53 targets

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Preclinical efficacy of a carboxylesterase 2-activated prodrug of doxazolidine

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Cancer-derived p53 mutants suppress p53-target gene expression--potential mechanism for gain of function of mutant p53.

22 May 2018

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Transcriptional activation of the carboxylesterase 2 gene by the p53 pathway

22 May 2018

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Analysis of P53 mutations and their expression in 56 colorectal cancer cell lines

22 May 2018

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SW480, a p53 double-mutant cell line retains proficiency for some p53 functions

22 May 2018

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P53 abnormalities and outcomes in colorectal cancer: a systematic review.

22 May 2018

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Mutant p53 exerts a dominant negative effect by preventing wild-type p53 from binding to the promoter of its target genes

22 May 2018

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

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Carboxylesterases expressed in human colon tumor tissue and their role in CPT-11 hydrolysis

22 May 2018

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p53 downstream targets and chemosensitivity.

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Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

22 May 2018

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Direct interaction of p53 with the Y-box binding protein, YB-1: a mechanism for regulation of human gene expression

22 May 2018

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Characterization of CPT-11 hydrolysis by human liver carboxylesterase isoforms hCE-1 and hCE-2

22 May 2018

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Enterocyte differentiation is compatible with SV40 large T expression and loss of p53 function in human colonic Caco-2 cells. Status of the pRb1 and pRb2 tumor suppressor gene products.

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Hydrolysis of capecitabine to 5'-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide.

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Human carboxylesterase 2 is commonly expressed in tumor tissue and is correlated with activation of irinotecan

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12 December 2020

Transcriptional Regulation of the p21(WAF1/CIP1)Gene

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12 December 2020

Pharmacokinetics, metabolism, and excretion of irinotecan (CPT-11) following I.V. infusion of [(14)C]CPT-11 in cancer patients

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Targeting p53 in vivo: a first-in-human study with p53-targeting compound APR-246 in refractory hematologic malignancies and prostate cancer

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Fluoxetine reduces CES1, CES2, and CYP3A4 expression through decreasing PXR and increasing DEC1 in HepG2 cells

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Identifiers

DOI

10.1155/2018/5280736

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29651325%20AND%20SRC:MED&resulttype=core&format=json

release_qwy6azyegfd6be23frgpc27k5i

23 March 2020

Fatcat ID

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Fatcat

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24 November 2022

mapped directly with Wikidata item

1 reference

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23 March 2020

PubMed publication ID

29651325

1 reference