Plasma and cerebrospinal fluid pharmacokinetics of the Akt inhibitor, perifosine, in a non-human primate model. (Q54286593)

PubMed publication ID

25740692

27 May 2018

http://europepmc.org/abstract/MED/25740692

title

Plasma and cerebrospinal fluid pharmacokinetics of the Akt inhibitor, perifosine, in a non-human primate model (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6301001&resulttype=core&format=json

13 May 2020

0 references

1 reference

Diane E Cole

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6301001&resulttype=core&format=json

13 May 2020

Cynthia M Lester-McCully

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6301001&resulttype=core&format=json

13 May 2020

Brigitte C Widemann

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6301001&resulttype=core&format=json

13 May 2020

Katherine E Warren

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6301001&resulttype=core&format=json

13 May 2020

publication date

5 March 2015

1 reference

PubMed publication ID

25740692

27 May 2018

http://europepmc.org/abstract/MED/25740692

published in

Cancer Chemotherapy and Pharmacology

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6301001&resulttype=core&format=json

13 May 2020

volume

75

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6301001&resulttype=core&format=json

13 May 2020

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6301001&resulttype=core&format=json

13 May 2020

page(s)

923-928

1 reference

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Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo

13 May 2020

cites work

1 reference

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Akt activation is a common event in pediatric malignant gliomas and a potential adverse prognostic marker: a report from the Children's Oncology Group

21 January 2018

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PTEN promoter methylation and activation of the PI3K/Akt/mTOR pathway in pediatric gliomas and influence on clinical outcome

21 January 2018

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The alkylphospholipid perifosine induces apoptosis and p21-mediated cell cycle arrest in medulloblastoma.

21 January 2018

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Deregulation of the Akt pathway in human cancer

21 January 2018

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

21 January 2018

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North Central Cancer Treatment Group Phase I Trial N057K of Everolimus (RAD001) and Temozolomide in Combination With Radiation Therapy in Patients With Newly Diagnosed Glioblastoma Multiforme

21 January 2018

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A pilot study of everolimus and gefitinib in the treatment of recurrent glioblastoma (GBM).

21 January 2018

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Alkylphosphocholines: Effects on human leukemic cell lines and normal bone marrow cells

21 January 2018

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Erufosine, an alkylphosphocholine, with differential toxicity to human cancer cells and bone marrow cells

21 January 2018

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Perifosine: update on a novel Akt inhibitor.

21 January 2018

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In vitro cytotoxicity of the novel antimyeloma agents perifosine, bortezomib and lenalidomide against different cell lines

21 January 2018

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Pharmacodynamic markers of perifosine efficacy

21 January 2018

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Phase I and pharmacological study of daily oral administration of perifosine (D-21266) in patients with advanced solid tumours

21 January 2018

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A phase I trial of perifosine (NSC 639966) on a loading dose/maintenance dose schedule in patients with advanced cancer

21 January 2018

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First-time-in-man and pharmacokinetic study of weekly oral perifosine in patients with solid tumours

21 January 2018

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Inhibition of Akt by the alkylphospholipid perifosine does not enhance the radiosensitivity of human glioma cells

21 January 2018

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Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma

21 January 2018

1 reference

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Zidovudine concentration in brain extracellular fluid measured by microdialysis: steady-state and transient results in rhesus monkey.

21 January 2018

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Extracellular fluid concentrations of cisplatin, carboplatin, and oxaliplatin in brain, muscle, and blood measured using microdialysis in nonhuman primates.

21 January 2018

1 reference

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Quantitative determination of perifosine, a novel alkylphosphocholine anticancer agent, in human plasma by reversed-phase liquid chromatography-electrospray mass spectrometry.

21 January 2018

1 reference

12 December 2020

Perifosine, a novel alkylphospholipid, inhibits protein kinase B activation

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12 December 2020

In vitro and in vivo inhibition of neuroblastoma tumor cell growth by AKT inhibitor perifosine

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12 December 2020

A rhesus monkey model for continuous infusion of drugs into cerebrospinal fluid

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12 December 2020

10.1007/S00280-015-2711-1

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6301001&resulttype=core&format=json

release_2qdsbkmhn5b5pnyq5xqna3y5oq

13 May 2020

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/2qdsbkmhn5b5pnyq5xqna3y5oq

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6301001&resulttype=core&format=json

13 May 2020

PubMed publication ID

25740692

1 reference