Caspase-8: A Novel Target to Overcome Resistance to Chemotherapy in Glioblastoma (Q60928004)

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Alessandra Ferri

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Claudia Cirotti

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Venturina Stagni

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Daniela Barilà

International Journal of Molecular Sciences

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language of work or name

English

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publication date

29 November 2018

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25 April 2019

28 September 2019

20 November 2019

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25 April 2019

28 September 2019

20 November 2019

19

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issue

12

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page(s)

3798

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copyright license

Creative Commons Attribution

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25 April 2019

28 September 2019

20 November 2019

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on focus list of Wikimedia project

ScienceSource

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cites work

FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis

1 reference

12 December 2020

Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor

1 reference

12 December 2020

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

1 reference

12 December 2020

Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

1 reference

12 December 2020

Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade

1 reference

12 December 2020

Activation of NF-kappaB by FADD, Casper, and caspase-8.

1 reference

12 December 2020

Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN

1 reference

12 December 2020

The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways

1 reference

12 December 2020

Activation of the NF-kappaB pathway by caspase 8 and its homologs

1 reference

12 December 2020

Resistance to TRAIL-induced apoptosis in primitive neuroectodermal brain tumor cells correlates with a loss of caspase-8 expression.

1 reference

12 December 2020

NF-kappaB signals induce the expression of c-FLIP.

1 reference

12 December 2020

Integrin-mediated death: an explanation of the integrin-knockout phenotype?

1 reference

12 December 2020

Src in cancer: deregulation and consequences for cell behaviour

1 reference

12 December 2020

Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8.

1 reference

12 December 2020

Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency

1 reference

12 December 2020

Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity

1 reference

12 December 2020

Loss of caspase-8 protein expression correlates with unfavorable survival outcome in childhood medulloblastoma.

1 reference

12 December 2020

c-FLIP mediates resistance of Hodgkin/Reed-Sternberg cells to death receptor-induced apoptosis

1 reference

12 December 2020

Expression of the cellular FLICE-inhibitory protein (c-FLIP) protects Hodgkin's lymphoma cells from autonomous Fas-mediated death

1 reference

12 December 2020

Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8

1 reference

12 December 2020

Targeting death receptors in cancer with Apo2L/TRAIL.

1 reference

12 December 2020

The flip side of FLIP

1 reference

12 December 2020

Requirement for caspase-8 in NF-kappaB activation by antigen receptor.

1 reference

12 December 2020

Caspase 8 is absent or low in many ex vivo gliomas.

1 reference

12 December 2020

Potentiation of neuroblastoma metastasis by loss of caspase-8.

1 reference

12 December 2020

Mechanisms of angiogenesis in gliomas

1 reference

12 December 2020

Caspase-8 promotes cell motility and calpain activity under nonapoptotic conditions

1 reference

12 December 2020

Src kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppression

1 reference

12 December 2020

Caspase-8 regulation by direct interaction with TRAF6 in T cell receptor-induced NF-kappaB activation.

1 reference

12 December 2020

Role of proteolysis in caspase-8 activation and stabilization

1 reference

12 December 2020

ATM kinase activity modulates Fas sensitivity through the regulation of FLIP in lymphoid cells.

1 reference

12 December 2020

Relationship between survivin expression and recurrence, and prognosis in hepatocellular carcinoma

1 reference

12 December 2020

Caspase-8 interacts with the p85 subunit of phosphatidylinositol 3-kinase to regulate cell adhesion and motility

1 reference

12 December 2020

Novel noncatalytic role for caspase-8 in promoting SRC-mediated adhesion and Erk signaling in neuroblastoma cells

1 reference

12 December 2020

Identification of a critical tyrosine residue in caspase 8 that promotes cell migration

1 reference

12 December 2020

Identification of Novel Mammalian Caspases Reveals an Important Role of Gene Loss in Shaping the Human Caspase Repertoire

1 reference

12 December 2020

Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy

1 reference

12 December 2020

Structural and biochemical studies on procaspase-8: new insights on initiator caspase activation

1 reference

12 December 2020

Caspase-8 association with the focal adhesion complex promotes tumor cell migration and metastasis

1 reference

12 December 2020

Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling

1 reference

12 December 2020

Human caspases: activation, specificity, and regulation

1 reference

12 December 2020

Studies of the molecular mechanism of caspase-8 activation by solution NMR.

1 reference

12 December 2020

Rab5 mediates caspase-8-promoted cell motility and metastasis

1 reference

12 December 2020

Review: on TRAIL for malignant glioma therapy?

1 reference

12 December 2020

Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

1 reference

12 December 2020

Caspase-8 as a therapeutic target in cancer

1 reference

12 December 2020

ATM kinase activity modulates cFLIP protein levels: potential interplay between DNA damage signalling and TRAIL-induced apoptosis

1 reference

12 December 2020

BID is cleaved by caspase-8 within a native complex on the mitochondrial membrane

1 reference

12 December 2020

Functional complementation between FADD and RIP1 in embryos and lymphocytes

1 reference

12 December 2020

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

1 reference

12 December 2020

Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis

1 reference

12 December 2020

Hallmarks of Cancer: The Next Generation

1 reference

12 December 2020

The NFκB pathway: a therapeutic target in glioblastoma

1 reference

12 December 2020

Targeting the Anti-Apoptotic Protein c-FLIP for Cancer Therapy

1 reference

12 December 2020

Emerging insights into the molecular and cellular basis of glioblastoma

1 reference

12 December 2020

TRAF2 Sets a threshold for extrinsic apoptosis by tagging caspase-8 with a ubiquitin shutoff timer

1 reference

12 December 2020

Src-inducible association of CrkL with procaspase-8 promotes cell migration

1 reference

12 December 2020

A New Player in the Development of TRAIL Based Therapies for Hepatocarcinoma Treatment: ATM Kinase

1 reference

12 December 2020

Caspase-8 as a regulator of tumor cell motility

1 reference

12 December 2020

Functions of caspase 8: the identified and the mysterious

1 reference

12 December 2020

Targeting apoptosis for anticancer therapy

1 reference

12 December 2020

Evolutionary analyses of caspase-8 and its paralogs: Deep origins of the apoptotic signaling pathways

1 reference

12 December 2020

Caspase-8 tyrosine-380 phosphorylation inhibits CD95 DISC function by preventing procaspase-8 maturation and cycling within the complex

1 reference

12 December 2020

Caspase-8 expression and its Src-dependent phosphorylation on Tyr380 promote cancer cell neoplastic transformation and resistance to anoikis

1 reference

12 December 2020

Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex

1 reference

12 December 2020

Non-apoptotic functions of caspases in myeloid cell differentiation.

1 reference

12 December 2020

Caspase-10 Negatively Regulates Caspase-8-Mediated Cell Death, Switching the Response to CD95L in Favor of NF-κB Activation and Cell Survival

1 reference

12 December 2020

Caspase-8: regulating life and death

1 reference

12 December 2020

Caspase-8 contributes to angiogenesis and chemotherapy resistance in glioblastoma.

1 reference

12 December 2020

Atg2A/B deficiency switches cytoprotective autophagy to non-canonical caspase-8 activation and apoptosis.

1 reference

12 December 2020

A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development

1 reference

12 December 2020

Caspase-10: a molecular switch from cell-autonomous apoptosis to communal cell death in response to chemotherapeutic drug treatment

1 reference

12 December 2020

Apoptosis: A Target for Anticancer Therapy

1 reference

12 December 2020

Caspase-8 function, and phosphorylation, in cell migration.

1 reference

12 December 2020

FLIP as a therapeutic target in cancer

1 reference

12 December 2020